^2nd Global Summit on Herbals & Natural Remedies October 17-19, 2016 Kuala Lumpur, Malaysia

Biography:

Shashi K Agarwal has obtained his Board Certification in Internal Medicine in 1979 and Cardiovascular Diseases in 1981. He is also Board Certified with the American Board of Integrative Holistic Medicine and the American Academy of Anti-Aging Medicine. He has been awarded Fellowship of the American College of Cardiology, American College of Physicians and the American College of Nutrition. He has presented over 150 scientific abstracts and published over 30 scientific papers in peer reviewed journals. His interest is in scrutinizing and disseminating evidence based data regarding the therapeutic role of various complimentary modalities and encouraging their integration into contemporary medicine.

Abstract:

Introduction: Cardiovascular diseases are the number one cause of morbidity and mortality in the world. Traditional herbal concoctiosns and herb derived drugs are commonly used in these ailments. These three abstracts review popular herbal remedies which have demonstrated beneficial cardiovascular effects and results have been validated by rigorous scientific studies.rnrnMethods: PubMed interrogation revealed 65,034 entries under ‘herbal medicines’ and 2,963 under ‘herbal and cardiovascular’. Relevant citations were reviewed. Other pertinent published scientific material was also consulted.rnrnResults: Aesculus hippocastanum (Horse Chestnut): The seed extract standardized to around 20 percent aescin is often used for its anti-inflammatory and free radical scavenging properties. Its primary use, however, has been as an efficacious and safe short-term treatment for chronic venous insufficiency. Although the mechanisms are still not well understood, venous contraction appears to be mediated through 5-HT (2A) receptors. Allium sativum (Garlic): Properties of garlic (allicin) include reduction in blood pressure, inhibition of platelet aggregation, enhancement of fibrinolytic activity, reduction of lipid synthesis and protection of the elastic properties of major arteries. It also stimulates nitric oxide generation and reduces inflammation. Clinically, there is an improvement in unstable angina, peripheral artery disease and coronary calcification progression. Crataegus (Hawthorn): Several clinical trials have indicated significant benefits in its adjunctive role in the treatment for chronic heart failure. Mechanisms include catecholamine contraction and endothelial-dependent nitrous oxide induction related vaso-relaxation.rnrnConclusions: Several herbal medicines have convincingly established their therapeutic role as cardioceuticals. Evidence based scrutiny has repeatedly validated their efficacy and safety in clinical trials.rn

Biography:

Carrie Graves graduated from the Graduate School of Integrative Medicine in 2009. She has been incorporating Acupuncture and Integrative Medicine in her clinic in Clearwater Florida with great success. She has won Best Wellness Center and Best Acupuncture clinic in 2015. Dr. Carrie regularly speaks in the community on topics such as nutrition, genomic medicine, hormone regulation, and alternative medicine.

Abstract:

Successful alternative medical practices thrive with the integration of emerging technologies and holistic treatment methodologies. In practicing true preventative medicine, it is the practitioner’s responsibility to use all available resources to optimize the health of their patient. Personalized genomic testing is one such resource that evaluates an individual’s predisposition for nutrient absorption, metabolism, and potential toxic burden. This information facilitates custom approaches to disease prevention that can be incorporated into alternative medical fields such as Traditional Chinese Medicine, Naturopathy, and Ayurvedic practices. These holistic modalities examine constitutional patterns in diagnosing and planning patient treatment protocols. Combining genetic testing with alternative medicine can reveal valuable insights, allowing for more precise treatment regimes. This in turn provides the practitioner with additional tools to develop a more individualized disease management program, resulting in both measurable and impactful changes in their patient’s care.

Biography:

Amr Amin has completed his PhD at University of Illinois at Chicago, and received a post-doctoral training in the field of molecular genetics at the University of Pennsylvania School of Medicine. AT UAEU, Amr’s research focuses on GI cancers. He utilizes advanced technologies such as targeted drug delivery using nanoparticles, bioinformatics and system biology to assess the anti-cancer effects of selected natural-based drugs. He published many research articles and reviews and serves as reviewer and as an editorial member of many specialized peer-reviewed journals. He is also a member of many specialized societies and the sole recipient of many scientific awards.

Abstract:

Background: The angiogenesis inhibitor, sorafenib, remains the only available therapy of hepatocellular carcinoma (HCC). Only recently, patents of VEGF receptors-3 inhibitors have been developed. Thus, a novel approach against HCC is essential for a better therapeutic outcome. Objective: The aims of this study were to examine the chemopreventive action of saffron’s main biomolecule, crocin, against chemically-induced liver cancer in rats, and to explore the mechanisms by which crocin employs its anti-tumor effects. Method: We investigated the anti-cancer effect of crocin on an experimental carcinogenesis model of liver cancer by studying the anti-oxidant, anti-inflammatory, anti-proliferation, pro-apoptotic activities of crocin in vivo. In addition, we provided a network analysis of differentially expressed genes in tissues of animals pre-treated with crocin in comparison to induced-HCC animal tissues. To further support our results, in vitro analysis was carried out. We assessed the effects of crocin on HepG2 cells viability by treating them with various concentrations of crocin. In addition, effects of crocin on cell cycle distribution of HepG2 cells were investigated. Results: Findings reported herein demonstrate the anti-proliferative and pro-apoptotic properties of crocin, when administrated in induced-HCC model. Crocin exhibited anti-inflammatory properties whereby NF-kB, among other inflammatory markers, was inhibited. In vitro analysis confirms crocin’s effect in HepG2 by arresting the cell cycle at S and G2/M phases, inducing apoptosis and downregulating inflammation. Network analysis identified NF-kB as a potential regulatory hub, and therefore a candidate therapeutic drug target. Conclusion: Taken together, our findings introduce crocin as a candidate chemopreventive agent against HCC.

Biography:

Azza Hafiez El-Medany has completed her PhD and Postdoctoral studies from Alexandria University, College of Medicine, Egypt. She is the Professor of Pharmacology & vice Head of the Department of Pharmacology, College of Medicine, KSU. She has published more than 40 papers in the areas of GIT, CVS, natural products & toxicological researches in reputed journals and serving as a member of number of professional bodies. She is the recipient of special awards in scientific research & teaching.

Abstract:

Graeco-Arabic Medicine is a traditional medicine, which like other traditional medicine e.g., traditional Chinese medicine has a specific & unique set of principles and methods that are used in the diagnosis and treatment of health conditions. The Hellenistic origin of Graeco-Arabic Medicine is still visible in its being based on the classical four humors: Phlegm (Balgham), Blood (Dam), yellow bile (safra) and Black bile (sauda). Graeco-Arabic Medicine is known in the Middle East and the Asian area as Unani Medicine. Unani is an Arabic word that refers to the origin of these Medical Traditions in Ionia in ancient Greece and is principally based on the ancient methods of medicine that were used and taught by its traditional founders, namely Hippocrates, who lived in Greece between 460-370 BC & Galen who lived in Greece & Rome during 129-199 AD. Further considerable contributions were made by Avicenna, an Arabic scholar who lived in Iran between 980-1037

Biography:

Ananya Dechakhamphu is a lecturer at Faculty of Thai Traditional and Alternative Medicine, Ubon Ratchathani Rajabhat University, Thailand. She obtained her PhD in Medical Biochemistry at Khon Kaen University. She was a guest scientist at German Cancer Research Center and Karolinska Institute. Her research interest is the discovery and development of new bioactives on anti-obesity from Thai medicinal plants and Thai herbal recipes.

Abstract:

Obesity is becoming one of a worldwide epidemic, resulting in a major risk factor for chronic diseases. The prevalence of overweight and obesity is fetching high worldwide. Therefore, prevention and treatment of obesity are become an important factor for a healthy condition. The reduction of nutrient digestion and absorption by developing of enzyme inhibitors without altering major mechanism in gastrointestinal system became the most important strategies in the treatment of obesity. Pancreatic lipase is the key enzyme for dietary fat digestion and absorption. Therefore, inhibition of this enzyme would be in effect to reduce lipid absorption from intestine and lead to a consequence suppress of weight gain. Drug such as orlistat is being used to inhibit this enzyme, however, orlistat has been reported to have adverse effects. Therefore, it is a challenge to find alternative treatment to reduce blood lipid. Bioactive compounds from traditional medicinal plants used to inhibit pancreatic lipase are in our focus. In our study, we have screened for anti-pancreatic lipase of more than 98 Thai medicinal plants and 12 traditional herbal recipes. We found that extracts from 4 herbs and 3 herbal recipes strongly inhibited porcine pancreatic lipase. We have isolated flavonoids, alkaloids and polyphenols from these plants and recipes. The measurement of anti-pancreatic lipase activity was strongly related with the contents of isolated flavonoids, alkaloids and polyphenols. The observations and data gathered from the studies for the extracts of Thai traditional plants undoubtedly suggest that the extracts of these plants could be a potent anti-obesity. To elucidate the bioactive structures, the purification and identification of putative compounds is under investigated.

Biography:

Sreenivasan Sasidharan has completed his PhD from Universiti Sains Malaysia in 2007. He is the Associate Professor in Institute for Research in Molecular Medicine of Universiti Sains Malaysia, a public University in Malaysia. He has over 160 publications with total impact factor of 175, multiple book chapters, significant grant support, and over 100 posters/abstracts at national and international meetings as well as Organizer, Keynote, Invited Speaker and chair of International & National Congresses. Has been serving as an Editorial Board Member and Reviewer of international journals. He reviewed more than 100 manuscript for international journal. His research interests include Medicinal plants and their role in Health and Disease Management, Molecular Mechanisms and Biology of Free Radicals, Antioxidants, Anticancer, Antimicrobial and also isolations and identification of phytochemicals from local natural resources for various biotechnology purposes. He also graduated more than 15 post graduate student as main supervisor.

Abstract:

Radiotherapy plays an essential primary role in cancer patients. The findings of our current research also signify that the use of a natural anticancer remedies could inhibit cancer cells and concurrently, these natural remedies could exhibit radioprotective activity against the healthy cells during radiotherapy. The P. longifolia being the most important indigenous medicinal plants, are found throughout Malaysia and generally use by traditional healers to treat various diseases. The MTT assay results disclosed a lowest IC50 value of 14.181 µg/ml as P. longifolia leaf extract debilitate HeLa cells. The cytological observations underlined cell shrinkage, nuclear and chromatin condensation, multinucleation, membrane blebbing, punctures, cytoplasmic extrusions and formation of apoptotic bodies, which are correlating within Light Microscope (LM), Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM) and HoloMonitor (HM) images. Further biochemical tests were performed to verify this apoptosis resemblance. P. longifolia is deduced to effectuate distinctive morphological features of cell death in conformity to apoptosis. Subsequently, the radioprotective effect of P. longifolia was studied in mice. P. longifolia treatment rendered remarkable improvement in mice survival (27 days), compared to 100% mortality in irradiated groups mice within 14 days.Significant increases in haematological parameters were observed in the animals pretreated with leaf extract. Pre-irradiation administration of P. longifolia leaf extract also increased the CFU counts of the spleen colony and increased the relative spleen size. A dose-dependent decrease in lipid peroxidation levels and a significant increase in superoxide dismutase and catalase activity were observed in the animals pretreated with P. longifolia. P. longifolia pretreatment also resulted in the regeneration of the mucosal crypts and villi of the intestine. Moreover, pretreatment with P. longifolia leaf extract also showed restoration of the normal liver cell structure and a significant reduction in the elevated levels of ALT, AST and bilirubin compared. We also firstly reported the protective effect of P. longifolia leaf on DNA damage-induced by hydroxyl radicals. Therefore, we have reported the potential uses of P. longifolia leaf as green therapeutic approaches, as well as radioprotectors against the adverse effects of irradiation on healthy cells during radiotherapy as a future prospects.

Biography:

Anirban Sukul completed his PhD from Visva-Bharati University and Research Associateship from the same University. He studied homeopathy and obtained Bachelor degree. Presently he is the Director of Sukul Institute of Homeopathic Research at Kolkata, India. He has published 22 papers in international journals and co-authored a book published by Kluwer Academic Publishers, The Netherlands. He has lectured on homeopathy in 12 countries across Europe and UK. He has been conferred the Junior Scientist Award, Life Time Achievement Award, Gold Medal Award, Man of Excellence Award etc from abroad. Dr Sukul is also Member, Liga Medicorum Homoeopathica Internationalis (LMHI), Germany

Abstract:

Will be updated soon!!

Biography:

Padmaja Vaidyanathan has completed her PhD from University of Kerala. She is Professor at College of Pharmaceutical Sciences, Thiruvananthapuram, a premier insitution imparting Pharmacy education. . She has published more than 30 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract:

With people turning towards herbal remedies more and more, the problem of herbal drug interactions is increasing. When a therapeutic combination could lead to an unexpected change in the condition of the patient, this would be described as an interaction of potential clinical significance . It is a major concern for the clinical therapistst,especially for elderly patients, who maybe taking multiple prescription drugs, also patients with impaired renal or liver function, or those taking critical drugs (e.g. anti-HIV drugs, chemotherapy) Some of the commonly used drugs, like aspirin, has the tendencyl to interact with herbal supplements which are known to possess antiplatelet activity (ginkgo, garlic, ginger, ginseng, turmeric, and willow) ennhancing the risk of bleeding. Another example is decreased bioavailability of digoxin, theophylline and cyclosporin when these drugs are combined with St John's wort; soluble fibre containing drugs can decrease the absorption of drugs. Many herbs can alter cytochrome P450 (CYP) metabolism. India has its traditional systems of medicines like Ayurveda and Sidha. Many people may be resorting to differnet systems of medicine.In many cases, mechanisms uncertain or unpredictable. Piper longum contains piperine, which has been shown in clinical trials to increase the absorption of phenytoin and propranolol. Garlic (Allium sativum) interacts with chlorpropamide, ritonavir and warfarin.Adverse reactions may also arise from the misuse of the wrong species of medicinal plants and use of products contaminated with potentially hazardous substances, such as toxic metals, pathogenic microorganisms, and agrochemical residues.

Biography:

MVDr. Martina Načeradská is the owner of a private veterinary practice on Krymská 23 in Prague, Czech Republic, since 2008. She won the Falling Walls Lab Award (Prague 2015) with her research project on “Breaking the wall in treatment of dermatophytosis”. In her research she focuses mainly on cats, dermatology, and dealing with behavioral problems. She has numerous publications in Czech scientific journals and actively participates in national and international congresses, holds presentations for pet owners and breeders, and collaborates with several Czech TV channels on educational series about animals.

Abstract:

Behaviour-related issues belong to the most challenging cases in my practice. Sedatives or psychopharmaca are usually recommended as a treatment of choice according to the “western medicine” literature. Sometimes it is really difficult to actually administer the medicine, as many of the animal patients tend to be full of fear and aggressive, especially cats. In contrast to this way of treatment stands the use of herbs, especially those picked by the animal itself. Cats love to chew on catnip or valerian root, which makes their basic clinical examination much easier. If the animal is relaxed, the owner is relaxed too and the compliance works better. Oncological patients are sometimes hard to manage; some animals suffer from inappetence, refuse to eat, refuse to accept the feeding tube due to different reasons – in such cases I use herbs such as carrot seed essential oil as appetite stimulant. Some animals may suffer from resistant bacterial infection such as Escherichia coli, often in combination with other comorbidities such as renal failure where very few or no antibiotics can be used. In my practice had good results with prescribing inhalation of e.g. almond or garlic essential oils to combat such infections. Case report will be presented on how particular herbs or their products used helped the patients in my practice.

Biography:

Ali Ghasemzadeh completed his PhD in 2011 from Universiti Putra Malaysia in the area of environmental plant physiology. The principal focus of his research is to understand how eco-physiological factors alter phytochemical constituents and pharmaceutical quality of herbs. He has expertise in natural products, bioassay, pharmaceutical quality of Herbs and drug discovery. He published more than 40 ISI papers, chapters, monographs, and presented more than 60 papers nationally and abroad. He is reviewer of some journals such as Journal of natural products, Food chemistry, Journal of food science and technology, Plant food for human nutrition, etc. Currently, he is research fellow at Department of Crop Science, Faculty of Agriculture University Putra Malaysia.

Abstract:

Herbs and natural products are precious sources of medicinal compounds and their benefits and importance for healing have been well recognized since ancient times. The characteristics and health effects of natural bioactive compounds, especially from herbs, have been extensively investigated. Herbal drugs are obtained from cultivated or wild plants and constituents vary considerably depending on several factors that impair the quality control of phytotherapeutic agents. Standardization and quality control of medicinal plants/spices involve several steps. However, the quality and source of raw materials play an essential role in guaranteeing the quality and stability of herbal preparations. Other factors such as water availability, temperature, light exposure, nutrients, time and method of collecting, drying method, packing, storage and transportation of raw material, age and part of the plant collected, etc., can greatly affect the quality and consequently the therapeutic value of herbal medicines. Thus, proper standardization and quality control of raw material and the herbal preparations themselves should be permanently carried out. In the cases where the active principles are unknown, marker substance(s) should be established for analytical purposes. A herbal monograph gives a basic description of the herb, and list its chemical constituents, actions, clinical uses and recommended dosage. Herbal monographs normally include nomenclature, part used, constituents, range of application, contraindications, side effects, incompatibilities with other medications, dosage, use, and action of the herb. Scopes of herbal drug monograph are quality, safety, minimize the risk potential by clear definitions, identifications, tests and assay. Based on the above explanation, in order to guarantee safety and efficacy, herbal drugs must undergo serious quality control. Old monographs have to be updated and new methods have to be implemented.

Biography:

Mohammad Zashim Uddin obtained Ph. D. at the age of 32 years and trained from USA on tropical biodiversity. His current position is Professor in the University of Dhaka and supervised 27 M.S. research students and presently guiding one Ph. D student. By this time, he published 57 research articles in different scientific journals. Recipient of numerous awards and grants, Dr. Zashim has participated at least 43 events of training program/ workshop/ international conference. He served as biodiversity expert in 22 research projects here in Bangladesh. His current research focuses are on threatened ethnomedicinal plants and conservation of forest biodiversity.

Abstract:

Ethnobotanical study of medicinal plants used by the local people living in and around Lawachara National Park was conducted between the periods of December 2014 to November 2015. The main purposes of the study were to record and document plant species used for the treatment of various ailments and to find out the level of consensus between informants regarding the uses of plants for particular ailment categories. A total of 123 medicinal plant species with 244 formularies to treat 53 ailments have been recorded. For each species scientific name, local name, family, parts used, ailments and application modes have been presented. Leaf is the dominant parts used followed by Fruits, root and rhizome, whole plants, seeds, stem, bark, leaf and bark, petiole, bulb, peduncle, latex and flowers. Oral application is the main mode treatment in the study area and followed by external application. Maximum formularies were found in the six ailment groups including gastrointestinal complain, diarrhea and dysentery, fever and cough, dermatitis, jaundice and impotence. Maximum Fic values (more than 0.80) obtained in case of Cut and wound, Jaundice, Respiratory related ailments, Diabetes, Diarrhoea and dysentery, Anthelmintic, Gastrointestinal complain, Impotence, Dermatitis and High blood pressure. Chromolaena odorata, Cericoides campanulata, Oroxylum indicum, Cuscuta reflexa, Averrhoa carambola, Cajanus cajan, Adhatoda zeylanica and Citrus aurantifolia showed 100% Fl values. Litsea glutinosa, Mikania cordata, Ocimum sanctum and Azadirachta indica were scored maximum Cf values. It is recommended that species showed high Fic, Fl and Cf values could be used for further ethno-lead phytochemical analysis to find active compounds from plants.

Biography:

S. Mukanganyama completed his PhD at the age of 30 years from University of Zimbabwe and did postdoctoral studies at the Department of Chemical Pathology at the University of Cape Town, South Africa. He is an Professor of Biochemistry and the Head of the Department of Biochemistry at the University of Zimbabwe. He has published more than 35 papers in reputed journals and supervised more than 10 postgrdaute students.

Abstract:

The World Health Organization suggests that medicinal plants are the best source of obtaining a variety of drugs, therefore, there is need for better understanding of their properties, efficacy and safety. Humans are afflicted with many microbial pathogens that include bacteria, fungi and mycobacteria. However, due to the abuse of antimicrobial agents, most microbes have developed resistance. Plant species used by herbalists might be used as alternative sources of novel antimicrobial agents. Our research focus has been to study the effects of plant extracts and or their pure constituents on the growth of bacteria, fungi and mycobacteria. Chief to our investigations was the need to determine the mechanism by which herbal medicines and their phytochemicals work at a molecular level. Our results show that many of the plant derived compounds work by interfering with cell membrane integrity and this results in protein leakage or nucleotide leakage from the cells of pathogens. Some of the extracts work by interfering with transport across the membrane where the efflux of compounds from the inside to the outside is blocked. It was also noted that other phytochemicals targeted the virulence factors of the microbial species and these included inhibition of excretion of exo-enzymes such as phospholipases and proteases. Bacterial biofilms are structured communities of bacterial cells embedded within a self – produced matrix. Our results also show that disruption of biofilm formation is another mechanisms by which phytochemicals work. Phytochemicals that exhibit multiple mechanisms of actions and novel mechanisms of action need to be identified.

Biography:

Somashekar Shetty was awarded the Ph.D. by Manipal University in 2005. He has nearly 19 years of experience teaching Biochemistry to medical students in Melaka Manipal Medical College, Manipal University, Manipal, India, AIMST University Malaysia and American University of Antigua, West Indise. He is experienced in medical curricula with PBL and other self-directed learning approaches He has 13 scientific publications and 21 conference presentations to his credit. He is a reviewer for many journals and is a recognized Ph.D. guide for Manipal University, India. His main research area has been Wound Healing and Indigenous Drugs: Role as Antioxidants

Abstract:

Introduction- Traditional medicine, especially herbal medicine has recently been receiving heightened interest all over the world. Man from the very beginning has been aware of the problems of the life and has been taking care of health through diet and drugs for which plants were used extensively. Screening of the traditional medicinal plants and others is expected to provide drugs for antibiotic resistant infectious diseases, new epidemics, various types of cancers, wound healing, aging related ailments and AIDS. Efforts are also underway to genetically engineer the plants to acquire the life saving medicinal properties. Recent WHO studies indicate that over 30% of the world’s plant species have been used for medicinal purposes. The products relating to about 20,000 higher plant species are being marketed world over. About 120 chemical compounds of plant origin have been developed into modern pharmaceuticals. The main objectives of this study is to experimentally verify some indigenous drugs claimed to promote healing of wounds on a scientific basis and to identify the effects of plant materials on processes and attributes of wound healing. There have been no reports on any established clinically exploitable chemical agent promoting normal wound healing in the nutritionally and endocrinologically normal individual. However, many folk medicines and indigenous drugs are reported or claimed to influence wound healing. Some of the drugs mentioned in text and certain others which are used traditionally in and around of our state of Karnataka and which have been claimed to have healing properties, were subjected to experimental assessment.

Biography:

Atmaram Bandivdekar completed his Ph D Degree at the age of 31 years from Mumbai University. Bandivdekar was the Post-Doctoral and Carrier fellow at Population Council, New York. He was also the visiting scientist at UC Davis Primate Center. He is the Deputy Director of National Institute for Research in Reproductive Health which is the premier Institute in India in the field of Reproductive Health Research. He has published more than 70 papers in peer reviewed journals and also the book and two conference proceedings. He also has six National and International awards for his scientific contributions. Bandivdekar is actively involved research on understanding sexual transmission of HIV and development of preventive and therapeutic vaccine and formulation for prevention of HIV transmission.

Abstract:

Breastfeeding is known to be the effective method for reducing the infant’s malnutrition. Many traditional practices have been utilized for increasing milk quantity during lactation. Galactagogue from herbal remedies of Cyperus rotundus (Nagarmotha), Foeniculum vulgare (Fennel), Gmelina arborea (Shiwan), Gossypium herbaceum (Kapashy), Ipomoea digitata (Bhui-kohala), Lepidium sativum (Aalive), Pennisetum americanum (Bajra), Ricinus communis (Castor) and Trigonella foenum-graecum (Methi) are being considered to be promising herbals for induction of lactation. The study demonstrated that oral administration of Female rats with aqueous extract of these plants during their first lactation showed increase in pups body weight. The measurement of milk production during lactation was achieved by measuring pup weights during suckling period. Pup weight gain and weight of mother rats of extract treated groups were significantly higher than control group. About 30 to 50% more milk was produced in experimental group of animals as compared to that of the control groups of animal. The aqueous extracts of these plants were found to significantly stimulate the prolactin and maintaining the level of stress hormone i.e. cortisol. Additionally protein and carbohydrate content of mammary gland tissue were also significantly higher than control group of animals. In addition, the mammary gland tissues of experimental group showed obvious lobulo-alveolar development with milk secretion. Administration of aqueous extracts of these indigenous plants did not cause any signs or symptoms of toxicity in female rats at the highest dose up to 2000 mg/kg body weight. Also, significant changes were not observed in biochemical and histological profile of treated animals and controls, which implied that aqueous extracts of these indigenous plants are not harmful and toxicologically safe. The study demonstrated the efficacy and safety of these plants for stimulation of lactation in female rats and may be potential candidates for inducing lactation in women too.

Biography:

Moussa Ahmed is a medical microbiologist by specialty. He obtained his PhD degree from Mostaganem University Algeria. He is on the editorial board of many international medical and scientific journals. He is currently a Researcher in the Laboratory Pharmacognosy & Api-Phytotherapy Research laboratory Mostaganem University, Algeria.

Abstract:

To investigate the effect of unheated and heat-treated of Sahara honey. A total of 24 Swiss albino mice weighing 25–35 g were divided into four groups (n = 6). Anti-inflammatory effect was assessed at 1, 2, 3, 4, 5 and 6 h after subplantar injection of carrageenan (0.5 mL of a 1% solution in normal saline). In addition, total phenolic content was determined by modified Folin-Ciocalteu method. The total phenolic content capacity of the Sahara honey before and after heat treatment was between 72 and 97.9 mg of gallic acid equivalents/100 g of honey respectively. Administration of unheated honey (oral administration) reduced significantly (P < 0.05). The carrageenan induced mice paw edema model at 1, 3 and 6 h for 21.85%, 5.43% and 80.43%, respectively. Administration of heat-treated honey showed insignificant inhibition of carrageenan and induced paw edema at 1 h (31.16%), 3 h (0.25%) and 6 h (34.19%). The 50 mg/kg diclofenac exhibited percent reduction in paw volume 16.12%, 8.90% and 15.32% after 1 h, 3 h and 6 h, respectively, when compared with control animals. No toxicity was identified. Our results suggest that unheated Sahara honey has anti-inflammatory effects by reducing the mice paw edema size while heat-treated Sahara honey decreases the anti-inflammatory activity.

Biography:

Reshma A. Jain has completed her M. Pharm in Pharmacognosy in 2007 and then started the academic profession. She has 2 years teaching experience. She completed her PhD in 2015 from The M. S. University of Baroda, Vadodara, Gujarat. She is working as Assistant Professor in Faculty of Pharmacy. She had awarded UGC (University Grant Commission) JRF (Junior Research Fellowship) and SRF (Senior Research Fellowship) to her Ph.D project. She had awarded the DBT travel grant support to attend and participate at the conference Annual Meeting and Exposition (AAPS) 2011, Washington DC, USA. She had published research papers in reputed peer reviewed National and international journals and also gave 3 international and 1 national poster presentation. She had nominated for Dr. P.D. Sethi Annual award – 2011, Best Research Papers. She has been serving as a member of American Association of Pharmaceutical Scientists (AAPS) and MSU Pharmacy Alumni (MPA).

Abstract:

Immunomodulation deals with modifying immunity response using either natural or synthetic substances. To develop polyherbal formulation dose is the main factor to influence the process. The formulations are optimized for in-vitro antioxidant activity by applying factorial design. Factorial design, used to determine process variations, is applied for optimizing process parameters with reduced number of experiments. In current work, a four factor system consisting of the four herbal drugs such as Glycyrrhiza glabra root, Nelumbo nucifera leaves, aerial parts of Prunella vulgaris and fruits of Zizyphus jujuba and 24 runs were used for the optimization of formulations. The chosen dependent variable was EC50 (50% effective concentration). The lowest EC50 value (25.2 ± 1.27) of the batch indicates that 100mg dose of the all four plants give the best batch for the combination of all four plant extracts. Polyherbal formulations was screened for their in-vivo immunomodulatory activity using cyclophosphamide induced myelosupression models and in–vitro using NBT reduction test. Bone marrow suppression by cyclophosphamide was significant and was accompanied by lowered total WBC counts. Developed polyherbal formulations effectively increased the neutrophils’ functionality i.e. intracellular killing assayed by in-vitro NBT reduction test.

Biography:

Abstract:

Bilharzia or schistosomiasis is a parasitic disease related to water and poor sanitary conditions of the population . The infection is widespread in the world. Only malaria precedes in order of importance on the socio -economic and public health in tropical and subtropical regions. In the world about 200 million people are infected with schistosomiasis. We conducted a clinical trial in the Kalima Health Area ; to compare two treatments : Artemisia herbal tea and treatment stantand praziquantel . Two thousand and fifty (2050) subjects were diagnosed . One thousand two hundred and fifty (1250) subjects were not eligible . Patients included numbered 800 including 400 patients per treatment group . In Artemisia arm , 10 patients were excluded from the study including 4 lost to 2 protocol violations and 4 withdrawals of consent. Three hundred and ninety ( 390) patients were followed correctly until the end of the study. PZQ in the treatment arm , 15 patients were excluded from the study 10 of them lost to 3 protocol violations and 2 withdrawing consent. In this group three hundred and eighty five (385) patients were followed correctly. Artemisia is more effective than praziquantel to treat schistosomiasis. The cure rate was 97.7 % as against 71.4% in Artemisia PZQ . Both treatments were well tolerated clinically and biologically .

Biography:

Soma Sukul is working as an Assistant Professor, in the department of Botany, Visva-Bharati (A Central University), India since 2003. She has awarded PhD degree in 2007 and qualified National Eligibility Test (NET) in 1999. Her research interests are: diversity, phytochemistry, ethnobotany and heavy metal accumulation of pteridophytes; high dilution effects on plant models.

Abstract:

The extensive use of chemical fertilizers for increasing crop production has hardened the soil, decreased fertility, strengthened pesticides, polluted air and water, and released greenhouse gases, thereby bringing hazards to human health and environment as well. Though Organic fertilizers are biodegradable, sustainable, and environment friendly they are rather expensive and they break down according to nature’s rules. Thus their effectiveness is limited seasonally and nutrient ratios are often unknown. In this situation it is desirable to find out suitable agents, which would increase plant growth and yield without compromising with the quality of food and of soil. We have observed that the ultra high dilution of plant growth retardants, chlorocholine chloride (CCC) and maleic hydrazide (MH) can enhance growth and yield in Cajanus cajan (L.) Millsp, Abelmoschus aeculentus (L) Moench., Vigna unguculata L., and Oryza sativa L. As the drugs were prepared by succussion with 90% ethanol, before application each potentized drug was diluted with sterile water (1:5OO). Morphometric as well as biochemical studies were done to see the growth effect. In all the cases significant increase in morphometric as well as biochemical parameters were observed. The FPLC study of cow pea leaf protein revealed some new proteins. The aim of this work was to see the effect of growth retardants at ultra high dilution on plant growth and yield.

Biography:

Sekagya Yahaya H is a Dental Surgeon with a Master of Public Health degree. He did apprentice in African Traditional Medicine for 6 years, holds a Diploma in Environmental Science and Practical Skills and he is a Student of African Spirituality in Health. He is the President PROMETRA Uganda and Founder of Dr. Sekagya Institution of Traditional Medicine and Indigenous Knowledge.

Abstract:

The study was to establish the factors influencing use of traditional medicine by patients under palliative care at Hospice Africa Uganda. It was carried out between January and June 2015 using a cross-sectional survey targeting 207 adult respondents who were consecutively sampled. Key informants were also purposively selected. The data was analyzed using both descriptive and inferential statistics (chi-square and logistic regression) to generate odds ratios. Results showed that advice from family, friends and other patients, (AOR=46, p=0.000) and religion (AOR=25, p=0.000) were positive factors influencing use of traditional medicine. However, the influence of doctor being aware that the patients was using or not using traditional medicine (AOR=0.184, p=0.000) was of negative influence. The rest of the factors; sex, age, marital status, education level, cultural beliefs, type of illness, past medical experience, availability and affordability of medicine were not significant factors influencing use of traditional medicine (p>0.05). Study recommends government to make policy on traditional medicine, Hospice Africa Uganda to scale up significance of social support for palliative care, palliative care organizations to sensitize religious leaders on palliative care and role of traditional medicine and The National Council of Education to include in the curriculum for medical students, doctors and nurses course units on traditional medicine.

Biography:

Malta Aiko Magbitang is a senior resident of Ospital ng Maynila Medical Center-Family and Community Medicine residency training program. She is a graduate of Medicine at Pamantasan ng Lungsod ng Maynila-College of Medicine.

Abstract:

Introduction: Diabetes mellitus is a progressive metabolic disease and if left untreated, it is associated with failure of various organs. The search of safer antidiabetic agents leads to research of traditional medicinal plants. Objective: This study aimed to determine the effect of Abelmoschus esculentus water on the postprandial blood sugar among healthy normal human subjects. Method: The study followed is a Randomized Open-Label Study. Normal healthy volunteers ages 20-60 years old were recruited at Ospital ng Maynila Medical Center. After an overnight fast, FBS were recorded. They were then randomized to okra water and placebo. Both groups were also fed a standard meal in addition to the water of their respective groups. Capillary blood glucose was measured after 2 hours and 4 hours. The difference in the blood glucose of both groups was compared. Results: The mean random blood sugar of the subjects after intake of standard meal 2 hour postprandial in okra water group (109.92±9.45 mg/dL) is greater than in the placebo group (108.35±9.93 mg/dL), but not statistically significant (p>0.05). Also, the mean RBS 4 hours postprandial is less in okra water group than in placebo group (95.23±6.99 vs 96.40±9.13 mg/dL) but is also not statistically significant (p>0.05). Overall, the mean blood sugar of the okra water group from baseline to postprandial has no significant difference as compared to placebo. Conclusion: Contrary to the previous animal studies, this present study, which used human subjects, showed no significant difference on the postprandial blood sugar level on subjects given with A.esculentus water as compared to placebo.

Biography:

Nidhi Ram is an Assistant Professor at Swami Vivekananda Yoga Anusandhana Samsthana University, India. As a part of her Doctoral work, she has estimated the prevalence of PCOS in adolescent girls from south India and also studied the efficacy of yoga based lifestyle program on adolescent girls with PCOS. Her work is published in international peer-reviewed indexed journals. She is presently conducting further research in the field of infertility.

Abstract:

girls in South India and to conduct a RCT to study the effect of integrated yoga based life style program in comparison to the standard physical exercise program in adolescent girls with PCOS. Out of the 460 girls who were screened (aged 15-18 years), 42 (9.13%) girls satisfied Rotterdam’s criteria for PCOS, which increased to 50.46 (10.97%) when imputed data were included. For the interventional study, 90 adolescent girls (aged 15-18 years, BMI≥18.5) who satisfied the Rotterdam criterion for PCOS and had no prior experience of yoga were randomized into Yoga and Exercise group (1 hour/day for 12 weeks). All the variables were assessed on day 1 and day 95, keeping 5 days of detraining phase after concluding the intervention. Comparing the change score between the two groups, Mann-Whitney U test on difference score showed significant (p<0.05) difference between the two intervention groups with greater improvement in the yoga group as compared to the control group in all the variables of hormonal profile except FSH and Prolactin in all the variables of biochemical profile except High Density Lipoprotein (HDL) and also in all the psychological variables except state anxiety. Changes in BMI, waist circumference (WC), hip circumference (HC) and waist-hip ratio (W/H) were non-significantly different between the two groups (p>0.05). In conclusion, these results suggest that integrated approach of yoga therapy for 12 weeks was significantly better in restoration of normal endocrine and biochemical with improvement in psychological profile of PCOS than physical exercises.

Biography:

Will be updated soon!!

Abstract:

Triterpenoid saponins (TS) are the most active ingredients of Korean red ginseng, especially in steamed ginseng root. Anti-inflammation, anti-tumor, and anti-oxidant activities of TS have been reported in relationship with many health benefits. Resolution phase of inflammation has recently been recognized as an active process derived by specialized pro-resolving mediators. Those mediators are supposed to be produced by M2 type-polarized macrophages. Among tested TS, PGM was found as the most active saponin inducing M2 polarization of macrophages. Furthermore, PGM not only induced expression of M2 marker genes, such as arginase-1, but also influenced M1 marker genes, such as inducible nitric oxide synthase and cyclooxygenase-2. Resolution promoting activity of PGM was investigated in vivo in a murine zymosan-induced peritonitis model. PGM fastened the resolution process, when it was intraperitoneally injected at the peak inflammatory response in the peritoneal cavity. These results suggest that PGM induced M2 polarization in macrophages and thereby resolved the inflammation faster. KEY WORDS: Resolution, ginseng, triterpenoid saponin, inflammation

Biography:

Abstract:

At present, liver transplantation remains the only curative option for the patients with cirrhosis and end-stage liver diseases. The survival rate and recurrent diseases remains the major issue in the patient post-transplantation. Unani medicine is one of the oldest traditional system of medicine, has been treating chronic liver diseases and cirrhosis [Talayyaful-Kabid] since centuries. The purpose of our study was to assess the impact of Unani treatment in decompensated cirrhosis and collect data to warrant further clinical trials. We have conducted a case series with five patients of decompensated cirrhosis and portal hypertension. Cases were confirmed by fibroscan and ultrasound and treated with Unani treatment orally for 3 months. Results were evaluated based on fibroscan, liver function test, EQ5D, child pugh and TTO-TIME [trade-off question]. Significant improvement in liver function test, fibrosis and quality of life were achieved in these patients. We reviewed the literature related to the herbal constituents of chief medicines used for the treatment in this case. The herbs have been proved for its potential anti-oxidative, anti-inflammatory, hepato-protective, immuno-modulator and antiviral activities, suggesting plausible mechanisms of action in these cases. The preliminary findings indicate the potential therapeutic role of Unani treatment in decompensated cirrhosis. Clinical trials should be conducted to explore the further therapeutic potential of Unani treatment in decompensated cirrhosis. Keywords: Cirrhosis of liver, Unani Medicine, Complementary Medicine, liver fibrosis, chronic liver disease, Hepato-protective, regenerative herbs, liver diseases, traditional medicine, case series cirrhosis

Biography:

Dr. Mukesh Singh Sikarwar is currently working as Senior lecturer in Faculty of Pharmacy, AIMST University, Malaysia. He received his PhD in Pharmacy from K.L.E. University, Belgaum India in year 2011. His current area of research is herbal antioxidants, antidiabetics and antihyperlipidemics, novel drug delivery in herbal drugs, formulation and evaluation of herbal drugs and food safety. He has more than 10 year of experience in mentoring students in Pharmacognosy and chemistry subjects. He has published 53 research and review papers in various peer reviewed internationals and national journals and also serving as reviewer for many international journals. He has presented 23 research papers in various national and international conferences. He has attended many MOOC courses and Online CME from online learning programmers. He is a life member of APTI, member of Asian Council of Science Editors, annual member of Society for Ethnopharmacology, India and registered as pharmacist with M. P. State Pharmacy Council.

Abstract:

Breadfruit has potential for food and nutrition security and sustainable production in the tropics especially in Caribbean and ASEAN countries but it is under-utilised and commercial production is limited. It is rich source of nutrients and used as replacement for wheat and possess medicinal properties hence it has potential to be sold as nutraceutical. Artocarpus altilis (Family: Moraceae) is commonly referred to as breadfruit as the texture of the moderately cooked ripe fruit flavors like potato or similar to freshly baked bread. In Malaysia, breadfruit is called buah sukun and its popular Malaysian recipe is halwa Sukun. Other recipes include boiled Breadfruit in coconut milk, Breadfruit curry, sukun chips, sukun fritters (cekodok sukun), soup and fish cakes. Over 130 phyto-compounds especially flavonoides and polypheols are identified in various parts of breadfruit plant. Nutritional compositions includes protein, carbohydrate, fat, calcium, phosphorus, K, iron, niacin, thiamine and vitamin C. Keeping above information in consideration nuratceutical product of soft gel capsules for breadfruit powder extract can be prepared and characterize for its marker compounds and antioxidant potential. It can be used as main source of antioxidant and will have application in treatment of oxidative stress caused by diabetes, inflammation, cancer and many such diseases. It can also be replacement for wheat flour, Gluten free, GMO free without trans-fat, Keywords: Breadfruit, Nutraceutical, food and nutrition

Biography:

Azza Hafiez El-Medany has completed her PhD and Postdoctoral studies from Alexandria University, College of Medicine, Egypt. She is the Professor of Pharmacology & vice Head of the Department of Pharmacology, College of Medicine, KSU. She has published more than 40 papers in the areas of GIT, CVS, natural products & toxicological researches in reputed journals and serving as a member of number of professional bodies. She is the recipient of special awards in scientific research & teaching.

Abstract:

In search for drugs that can target cancer cell microenvironment in as much as being able to halt malignant cellular transformation, the natural dietary phytochemical curcumin was currently assessed in DMH-induced colorectal cancer rat model. The study enrolled 50 animals divided into a control group (n=10) and DMH-induced colorectal cancer control group (n=20) (20mg/kg.-body weight for 28 weeks) versus curcumin-treated group (n=20) (160 mg/kg suspension daily oral for further 8 weeks). Treatment by curcumin succeeded to significantly decrease the percent of ACF and tended to normalize back the histological changes retrieved in adenomatous and stromal cells induced by DMH. The drug also significantly elevated GSH and significantly reduced most of the accompanying biochemical elevations (namely MDA, TNF-α, TGF-β & COX2) observed in colonic carcinomatous tissue, induced by DMH, thus succeeding to revert that of MDA, COX2& TGF-β back to near normal as justified by being non-significantly altered as compared to normal controls. The only exception was PAF that was insignificantly altered by the drug. When taken together, it could be concluded that curcumin possess the potentiality to halt some of the orchestrated cross-talk between cancerous transformation and its microenvironmental niche that contributes to cancer initiation, progression and metastasis in this experimental cancer colon model. Envisioning these merits to a drug with an already known safety preferentiality, awaits final results of current ongoing clinical trials, before curcumin can be added to the new therapeutic armamentarium of anticancer therapy.

Biography:

Farheen Fatima has completed her PhD and serving as an assistant professor, teaching diagnostic microbiology and diagnostic parasitology. She did her post-graduation studies specializing in medical microbiology from one of the most reputed university- Manipal Academy of Higher Education, India. She conferred a doctorate degree in medical microbiology from Vinayaka Mission University, Salem. She has worked as a principal investigator in epidemiologic surveys centering microbial and co-investigator in sero-epidemiology and parasitic infections in children. She has extended my work in biochemical contents of microbes. As of the moment she is working with the desert herbs to explore their individual and synergistic antimicrobial potential.

Abstract:

DiallylDisulphide (DADS) is a phytochemical found in the plants of the genus Allium. It is the principal organosulphuric component of distilled garlic oil. Many medicinal benefits like antimicrobial, antiviral and insecticidal are attributed this compound. However the biochemical explanation for such an action remains unexplored. This current study strives to explore the explanation for antimicrobial activity of the compound using the most common skin inhabitant Gram positive bacteria, commonly causing nosocomial infections- Staphylococcus aureus. The Minimum Inhibition Concentration(MIC), Minimum Bactericidal (MBC) Concentration of DADS, its effect on growth curve and time kill curve of S.aureushas been established. In the current study S.aureus was cultured in the broth containing 1/8 MIl analytic tests. The biochemical components focused on were of those abundantly present and those that contribute to the materializC of DADS. The staphylococcal cells were harvested; biochemical components were extracted and quantitated using appropriate biochemicaation of the staphylococcal cell envelope total lipids, total lipid phosphorous and total carbohydrates. The biochemical component extracts of S.aureustested revealed significant reduction in the total lipids (70%), total lipids phosphorous (50%) and total carbohydrates (34%). This reduction in the components may be attributed to the hypolipidemic and hypoglycemic properties of DADS and could further lead to changes in the anabolic processes. Since the cell envelope of the bacterial cell is primarily made up of lipids, phospholipids and peptidoglycan (a carbohydrate polymer). The evident reductions in the studied components indicate reflective impact of DADS on the cell envelope of S.aureus. This study can be extrapolated in innovation of a new phytochemical-antibiotic against the life threatening multidrug resistant human pathogens.

Biography:

Suad Yousif Abdalla Alkarib has completed her PhD from University of Khartoum, Sudan. She is the Founder of College of Pharmacy in Karary University. Earlier she was the Director General Manager for the “Wafrapharma Laboratories Ltd. for drug manufacturing. She is the Member of the Sudanese Medical Council, Scientific Researches committee in Gum Arabic Board, Sudan, Arab Administrative Development Organization (League of Arab States). She is the Rapporteur of the Industrial Pharmacy Committee in the Pan Arab Colleges of Pharmacy. She is the Member of the proposed fellowship in Technology of Industrial Pharmacy (Council of pharmaceutical specialties, Sudan). She has published more than 15 papers in different journals and conferences.

Abstract:

Introduction: Gum arabic acacia is a complex, loose aggregate of sugars and hemicelluloses composed of Arabic acid nucleus, it is found in nature and exists as a natural or slightly acidic calcium, magnesium, potassium or sodium salt of complex polysaccharide and the different metal ions present in gum arabic molecules, Chemically, it is an arabinogalactan protein complex composed by weight of 17-34% arabinose, 32-50% galactose, 11-16% rhamnose, 13-19% glucuronic acid and 1.8-2.5% protein. Serum electrolytes play specific roles in optimization of the blood pressure and hence the kidney functions. Methodology: It is a randomized control trial study, it was performed using (14) volunteers with different blood pressure readings and different kidneys function with six months past history. Dose of 10,15,20 and 25 grams of gum dissolved in 250 ml drinking water to be taken at the morning, were used for a duration of 16-18 weeks with interval every four weeks for every dose. Blood samples were taken for electrolytes analysis first as a control and after every interval before starting the next dose and the blood pressure was read after every interval. Results: The electrolytes levels showed biological rearrangement optimized referenced readings and hence the blood pressure both systolic and diastolic at a dose ranges 20-25 gm. Conclusion: There is a significant correlation between Gum acacia and electrolytes control in blood serum and hence the blood pressure, this depends upon the different Gum components ratios.

Biography:

Erna Sulistyowati has been puersuing her Ph.D program at Kaohsiung Medical University, Taiwan since 2014. She is either a medical doctor and lecturer at Faculty of Medicine, University of Islam Malang Indonesia. She has been doing research about herbal medicine related to cardiovascular system. She also has already got doctor’s clinical licence in Indonesian traditional practice (Dokter Praktek Jamu). She has published more than 12 papers in Indonesian journals. Recently she is doing herbs-medicine research as a part of scientific program of jamu in Indonesia traditional medicine.

Abstract:

Most of Indonesian rural community use decoction extract of Centella asiatica (L.) Urban (C), Justicia gendarussa (J) and Imperata cylindrica (I) to treat hypertension. This study purposed to get its rational form in lowering blood pressure and its effect on heart tissue prevention through oxidative stress inhibition. This experimental laboratory study divided 30 males (180-200 g) Wistar Kyoto rats and Spontaneous Hypertensive rats (SHR) into two groups, control (CTL) (aquadest) and treatment group (oral administered decoction of C (9 mg), J (9 mg), and I (5,4 mg)), once daily for 5 weeks. Weekly observation on systolic blood pressure (SBP), heart rates, metabolic profiles (body weight, food consumption, drinking water, urine volume and stool weight). Echocardiography examination were taken before sacrifice. Oxidative stress assays were measured on serum and heart tissue lipid peroxidation and reactive oxygen species (ROS). Treatment group showed lowering weekly systolic blood pressure on spontaneous hypertensive rat (SHR) respectively (p<0.01) and slower heart rates compared to SHR CTL group (p<0.05). There were no changes in metabolic profiles among all groups. Treatment group had increased in left ventricular heart fractional shortening (FS) and ejection fraction (EF) on SHR group (p<0.01). Treatment group demonstrated diminished serum (p<0.001) and heart tissue (p<0.01) malondialdehyde, anion superoxide and hydrogen peroxide generation on SHR group (p<0.01). Given decoction extract of CJI lowered SBP and protected heart by oxidative stress diminution on SHR. These findings suggest that CJI has potential therapeutic in the treatment of hypertension. Keyword: Centella asiatica (L.) Urban, Justicia gendarussa, Imperata cylindrica, decoction, oxidative stress, hypertension

Biography:

Physicians Trần Minh Đức & Nguyễn Thị Triệu from Vietnam, they are pursuing a combination of natural herbal and medicinal artificially to create a new breakthrough towards helping improve the quality of life. They are rediscovering nature and nurture as safer in treatment, cost effective health and healing resources

Abstract:

Phyllanthus Cantoniensis Hornem - Herba Adenosmatis Caerulei - Herba Eclipta - Vitamin C combination plus Tenofovir in treatment of acute and chronic hepatitis B. Method the combination of drugs derived from natural and artificial medicaments. Has stronger effect on immune system, effective good against HBV replication. This is a substantial new insight into the pathogenesis of disease, with a clear path toward clinical application, or which would lead to a substantial advance and perfect in management or public health policy. Triple

Biography:

Arunabha Ray holds an MD and a PhD and is the Chair, Department of Pharmacology at the Vallabhbhai Patel Chest Institute, Faculty of Medicine, University of Delhi. He has more than 36 years teaching and research experience in basic and clinical pharmacology and toxicology and has been the recipient of several awards and honors for research excellence. He has more than 150 research publications, is Author of several text and reference book chapters, Editor of 04 books in his areas of expertise, and Author of a textbook in pharmacology.

Abstract:

Stress related disorders contribute to a significant proportion of global illnesses and adaptogens are herbal agents which have the potential to attenuate stress effects. Since its inception, the concept of adaptogens has evolved considerably and newer mechanisms have been proposed. As these agents have to be administered for a reasonably long period of time, the benefit versus risk ratio is important and herbal agents are definitely preferable over their synthetic counterparts. The brain, HPA axis and immune system play a crucial role in the expression of the stress response and studies were conducted to evaluate the possible interactive mechanisms in the adaptogenic effects of some herbal agents. The role of CNS-neuroendocrine-immune interactions during the adaptogenic effects of agents like Ocimum sanctum (Tulasi, OS), Azadirachta indica (Neem, AI) and Withania somnifera (Ashwagandha, WS), used in traditional medicine, were investigated in experimental animals. Restraint Stress (RS) was used as the experimental stressor, and the effects of RS and their modulation by OS, AI and WS extracts were assessed in albino rats. RS suppressed neurobehavioral (elevated plus maze test), endocrinal (plasma corticosterone) and immune (humoral and cell mediated) responses – effects that were differentially reversed by OS, AI and WS pre-treatments. Herb-drug interaction studies showed that endogenous neuromodulatory substances could be involved in the observed adaptogenic effects. Such interactive studies are of great significance for the convergence of traditional and modern medicinal concepts and for the development of newer, more effective and safer herbal agents for the treatment of stress related disorders.

Biography:

Achintya Kr. Deb has completed his MD in Panchakarma from Rajiv Gandhi University of Health Sciences, India. He is the Medical Director of Panchakarma Research & Training Centre Tripura, a leading institute of India under The Forest Department, Govt. of Tripura. He has attended many national and international seminars to promote Herbal system of medicine. He has also published more than 20 papers in books and journals. He is serving as an expert in Medicinal Plants Board of Tripura, under National Medicinal Plants Board of India.

Abstract:

Herbal remedies have been the most popular worldwide throughout the last decade. Herbal medicines are being used to treat the diseases as well as to maintain the health of healthy persons. Phytochemical analysis of plants reveals the active components which are responsible to fight against the pathogens in a better way than the synthetics. Further research work is very much essential to know the mode of action of the Herbal medicines that enhance the immune system of body to fight against the diseases. Panchakarma treatment, a glory of Ayurveda - Indian system medicine is being practiced in India since thousands of years where Herbal plants and medicines are used to expel out toxins from human body in a natural way to make person disease free and also to keep him healthy both physically and mentally. ‘Pancha’ means five and ‘Karma’ means procedures, these are: - Vamana, Virechana, Basti, Nasyam and Raktamookshana. They help to expel out toxins from the body through Mouth, Anal and Nasal route, and Skin pores Eco-tourism; means development of Tourism keeping in view the environment and local culture intact, the concept of Panchakarma treatment modality strongly supports the developmental activities of Eco-tourism in Tripura, India. Eco-tourism activities of Tripura are well developed and have touched too many milestones, and people throughout the world have been interested to have the benefit of Panchakarma for better living. Further scope of development in Eco-tourism and Health-tourism remains as The Govt. of India and Tripura have taken very good initiative to develop the above sectors.

Biography:

Salah Akkal has completed his PhD at the age of 39 years from Constantine University. He was supervised on 4 M.Sc. thesis and 8 Ph-D. He is professor for natural product chemistry since 2007 in Chemistry Department, Faculty of science. He has published more than 70 papers in reputed journals and has been serving as an editorial board member of repute and has been serving as a reviewer for many articles in her specialization. He attended more than 15 International Conferences He teaching all the organic chemistry and natural product courses for the students of Faculty of Science and Faculty of Technology in University of Constantine, Algeria

Abstract:

The Apiaceae family is represented in Algeria by 28 genus and 146 species. Among this family, many plants of the genus are widely used in local herbal medicine, as they show a wide range of pharmacological activities. Many species of Apiaceae were used in folk medicine, as spices in cookery, but also as official medicinal drugs [1, 2].Thus, they account as a well-known source of essential oils and important herbal products. They are included in various pharmacopoeias as antiseptic, expectorant, diuretic, carminative, vasodilator, or spasmolytic agents [3]. The purpose of this research concerns the phytochemical and the biological study of of some genus of the Algerian flora’s medicinal plants known as Return, Formula, Bupleurum, Daucus. The diverse methods of separation and purification of the methanolic extract of these plants to obtain many constituents. Many compounds belonging to different classes of secondary metabolites were isolated for the first time from the aerial parts of some species. These include flavonoids, coumarines, terpenoides an epoxide and a sugar which contributed to the diversity of natural products in the species. The structure elucidation of the isolated compounds was based on analyses of their spectroscopic data (1D and 2D NMR, UV, MS). Structure elucidations of the phytoconstituents were achieved using various spectroscopic methods such as 1D (1H, 13C) and 2D (COSY, HMQC, HMBC, NOESY) NMR, MS, IR and UV-Vis and by comparison of their data with those of published compounds. Analyses of the extracts by gas chromatography and GC-mass spectrometry (GC-MS) tentatively identified many compounds, the various extracts and isolated compounds of this species were studied for their antioxidant and antimicrobial activities. The isolation of these biological active compounds showed the real importance to investigate plants that can be sources of new compounds with clinical activities [4]. Keywords: Apiaceae, phytochemical study, essential oils, antimicrobial and antioxidant activity.

Biography:

Babar Ali has completed his Ph.D at the age of 30 years from Faculty of Pharmacy, Jamia Hamdard, New Delhi, India. He has five years teaching and research experience in the field of pharmaceutical sciences. Currently he is working as associate professor and head of department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy and Dentistry, Buraydah Colleges, Al-Qassim, Kingdom of Saudi Arabia since 2012. He has published more than 25 national and international papers and is serving as an international editorial board member of reputed journal.

Abstract:

Black cumin (Nigella sativa Linn.) belongs to family Ranunculaceae and commonly known as Kalajira and Kalonji. Black cumin has volatile oils, various esters of unsaturated fatty acids with terpene alcohols, isochinoline and pyrazol alkaloids. Objective of this work is to isolate different compounds from the methanol extract of Nigella sativa seeds. Different compounds were isolated with column chromatography. The column was eluted with petroleum ether, chloroform, methanol and their combinations in order of increasing polarity to isolate the compounds.Two new glycoside, decanyl nigelloic acid diglucoside, n-decanyl-3- aldehydic-4-methoxy-5-hydroxy benzoyl-5-β-D-glucofuranoyl-(2→1)-β-D-gluco pyranosyl-(2→1)-β-D glucopyranoside) and nigelabdienoyl triglucoside, homolabd- 5, 9 (11) -dien-16-onyl-β-D-glucopyranosyl (2→1)-β-D-glucopyranosyl (2→1)-β-D- glucopyranoside along with other seven known compounds were isolated from the seeds of black cumin. The structure of these new glycosides were elucidated and established by standard spectroscopic methods. Total nine compounds were isolated from the extract in which two new glycosides were isolated for the first time from the plant.

Biography:

Misra completed his Ph D in 1981 and got opportunity to work in the renowned groups of natural product chemistry: with Prof. F. Bohlmann, Technical University, Berlin (1982-84), Prof. H. Wagner, LM University, Munich (1991-92 and 1999-2000), Prof. H. Laatsch, GA University, Goettingen (1998), Prof. M. Pischetsrieder, FA University, Erlangen (2009- 10), besides the parent institute, the CSIR- CIMAP, Lucknow. He has published about 110 research papers in reputed international journals of medicinal and aromatic plants and has protected the promising inventions by filing suitable patents. He has recently retired from the position of Chief scientist and Head of Chemical Sciences Division of CSIR-CIMAP, Lucknow, India.

Abstract:

Traditional medicine has been an integral part of Asian society for centuries and a fresh interest in medicinal plants was revived in 1980s, when the harmful effects of synthetic drugs started surfacing. Now, people rely more on herbal drugs because of high prices and harmful side effects of synthetic drugs. It has become fast driven social phenomenon to depend upon the herbal products or traditional medicines prescribed by the practitioners of indigenous systems of medicine, viz. Ayurveda, Unani, Siddha, Homoeopathy, etc., in India and similar traditional systems of medicines, viz. TCM, etc., world over. With the increasing popularity and awareness of herbal drugs, the role of natural product chemists has significantly increased. Now, it has become necessary to study the detailed chemical components of established medicinal plants and develop their chemical profile to monitor the authentic presence in the herbal preparations and regulate their uses. Also, the invention of new natural sources of biologically active compounds, especially, from the waste materials, opens up further scope, in this direction. Isolation of new compounds with unusual chemical structures adds to the existing knowledge on structure elucidation and chemical dictionary for further use by medicinal chemists. In the present lecture, it is proposed to give examples of isolation of bioactive withasteroides from Withania somnifera, the Indian ginseng which is invariably used in about 90% of herbal products of India. The validation of most of the bioactivity in this plant has been done to show that they are associated mainly with the steroidal molecules present in it.

Biography:

Kavita Gulati holds a PhD and is a Professor in the Department of Pharmacology at the Vallabhbhai Patel Chest Institute, University of Delhi. She has more than 25 years teaching and research experience in basic and clinical pharmacology and herbal drugs and has been the recipient of several awards and honors for research excellence. She has more than 80 research publications, is Author of several text and reference book chapters, Co-Editor of 4 books in pharmacology.

Abstract:

Herbal drugs are emerging as viable alternatives for complex disease states and modern scientific methodology are being adopted to validate the effects of such agents used in the traditional systems of medicine. Translational research in medicine is a two-way street and aims at breaking down barriers between clinical and basic medical sciences to promote rapid transfer of knowledge from bench to bedside and vice versa. In pharmacological sciences and drug development, this concept is being utilized for accelerating the conversion of basic and/or clinical research findings to sustainable health care solutions. Bronchial asthma is a chronic inflammatory respiratory disorder with steroid dependent pharmacotherapy and the use of herbal agents is being explored in search of viable alternatives. UNIM-352 is a poly-herbal formulation, used in traditional medicine for bronchial asthma, and clinical and experimental studies were conducted to validate their observed effects. In the clinical study, UNIM-352 significantly enhanced the therapeutic effect of standard anti-asthma therapy as assessed lung function tests and symptomatology, as compared to the placebo group, indicating its efficacy as an adjunct therapy. In the experimental study, UNIM-352 demonstrated differential degrees of anti-inflammatory, immune-modulatory, broncho-relaxant, anti-remodeling, and antioxidant effects in rats, by using well established biomarkers for the above pathophysiological states. The results indicate that this poly-herbal agent could be used as an alternative/adjunct in the treatment of bronchial asthma. This study also highlights the importance of a translational approach in herbal drug research which could rationalize drug therapy of complex diseases.

Biography:

Suleiman has completed his PhD in the year 2009 from Al-Neelain University, Khartoum, Sudan. He has published more than 5 papers in reputed journals and has been supervised more than 10 MSc. Thesis.

Abstract:

Ethnopharmacological relevance: The present study provides significant ethnopharmacological information on plant species used in North Kordofan region, western Sudan. The study was undertaken with an aim to document the medicinal uses of the species known to some Northern Kordofan communities. Material and methods: The study was conducted between 2012 and 2013. The plants were identified and voucher specimens prepared. Information was collected by means of semi-structured interviews with 258 informants (195 men and 63 women). In addition, the use value (UV) of the species was determined and the informant consensus factor (ICF) was calculated for the medicinal plants researched in the study. Further analysis was carried out to compare results with previous studies from the study area and other regions of Sudan. Results: A total of 44 plant species representing 24 families were found to be commonly used in the treatment of 73 different human health problems. The families most represented were Leguminosae (18%), Caesalpiniaceae (9%), Malvaceae (9%), Asclepiadaceae (6.8%) and Combretaceae (6.8%). The highest number of plant species are used against digestive system disorders (23 species) followed by microbial infections (21 species) and dermatology (19 species). Among all the plant parts leaves (20%), roots (19%), fruits and bark (14% each) were the most preferred plant parts used by the informants. There was strong agreement among the informants as to the usages of the plants (informant consensus factor 0.63-0.93). The most important plants on the basis of use-value were Acacia nilotica, Acacia seyal, Balanites aegyptiaca, Cassia occidentalis, Cassia senna, Guiera senegalensis and Tamarindus indica. Conclusion: This study has helped to document information that may otherwise be lost to future generations. This is the first ethnobotanical study in which statistical calculations about plants are carried out by means of the ICF and UV methods in the study area. Plants with high ICF and UV values should be subjected for further phytochemical and pharmacological investigation for scientific validation.

Biography:

Tanveer Alam was born in Bijnor, India on 21st Jan. 1974. He received his Ph.D. Degree in the field of Natural Product Chemistry from Jamia Hamdard, New Delhi, India in 2001. From Nov. 2000 to Sept. 2001, he was a Research Associate at Jamia Hamdard, New Delhi, India and worked on synthesis of water soluble derivatives of Silymarin. Upon completion of his education, he started his career as an Executive-R&D in a Flavour & Fragrances Company and after words he had served as Manager & Head-R&D in different National & Multinational Herbal Industries. Dr. Alam has more than 15 years of R&D experiences in the field of Natural Products. He has been worked as Associate Professor in Eritrea Institute of Technology, State of Eritrea. He is Ph.D. supervisor in JJT, University, Rajasthan, India and Advisor in Natural Food Colours Industry. He is also a Member of Editorial Boards and Referee for more than Eight National & International Journals. Since March 2015, Dr. Alam is looking the Production Unit for commercialization of Omani Medicinal & Aromatic Plants at University of Nizwa, Sultanate of Oman.

Abstract:

The worldwide demand for natural colors is nowadays of great interest due to the increased awareness on the therapeutic properties of natural colors in public. Natural colors are derived from naturally occurring sources such as plants, insects, animals and minerals. Several synthetic colorants have been banned because they cause allergy-like symptoms or are carcinogens. Among the all-natural colors, plant-based pigments have wide range of medicinal values. The present topic, describes the detail information about chemistry of the major pigments and their medicinal importance found in naturally occurring color yielding plants and animals, which are helpful to further development of pharmaceutical formulation. Keywords: Natural food color, water soluble, extraction, pigments.

Biography:

Maria Theresia Darini has completed her PhD and currently working as an professor at Agriculture Faculty Sarjanawiyata Tamansiswa University, indonesia. she as published more than 10 papers in international journals and attend many international conferences world wide.

Abstract:

The study aims to explore the response of growth, yield and antioxidant content of Aloe vera plant in sandy soil which is marginal land to need added of fertilizer dosage combination to improve fertility. The experiment was conducted in the districts of Bantul sandy soil Special Region of Yogyakarta, crop production laboratory Sarjanawiyata Tamansiswa University and Research and Test Integrated Laboratory Gadjah Mada University. The research was arranged in a Randomized Complete Block Design factorial with three replications. The first factor dosage of manure, namely 10, 20 and 30 tons ha-1. The second factor dosage of urea fertilizer namely 0; 150; 300; 450 and 600 kg ha-1. Variable of observations include the components of growth, yield and antioxidants content. Analysis of the results using analysis of variance on a significant level of 5 % , followed by Duncan 's Multiple Range Test at the 5% significance level. The conclusion was interaction between manure and urea fertilizer dosage on all of variable observation. The growth and yield highest obtained on addition manure 30 ton ha-1 and urea 450 kg ha -1. Antioxidant content highest obtained addition manure 20 ton ha-1 and urea 30 kg ha-1. Keyword; Aloe vera, antioxidant, manure, sandy soil, urea

Biography:

Bhushan Bhavsar is the founder and Managing Director of the Company. He has worked for more than a decade into the herbal and food supplement industry. His knowledge and expertise into the industry is well respected and proven into the field of product development, regulations, research, manufacturing, packaging & designing, marketing, sales and logistics, collectively said to be providing all the services under one roof to set up your business Nationally and Internationally. Due to his full devotion and work towards Ayurveda, Dr. Bhavsar has been chosen as President of World Ayurveda Health Organization (WAHO) working currently in 9 countries – India, Switzerland, United Kingdom, The Netherlands, Belgium, Germany, U.A.E., Brazil and Canada. As an innovative product researcher, Dr. Bhavsar has found many proven solutions for various lifestyle diseases and holds product and design patents. Graduated as B.A.M.S. (Bachelor in Ayurvedic Medicine & Surgery) and M.B.A. (Healthcare & Hospital Management) with a Gold Medal, Post Graduate Diploma in Cosmetic Technology and L.L.B. (Bachelor Of Legislative Law) (Honors). Awarded twice with Gold Medal for ‘Best Business Strategic Planner’ and ‘The Entrepreneur’s Award’.

Abstract:

The global herbal supplements and remedies market is forecast to reach $107 billion by the year 2017, spurred by growing aging population and increasing consumer awareness about general health and well being, according to a new report from Global Industry Analysts. Additionally, the fact that herbal supplements and remedies cause little or no side effects and provide greater efficacy is also proving to be a major factor aiding market growth. The global herbal supplements and remedies market exhibited robust growth over the last decade, with little or no significant decline on account of the recent economic recession. The factors that fueled growth in the market include widespread acceptance of functional foods, rise in consumer confidence to include herbs in preventive health and alternative medicine regimens, supplier innovations, and the much awaited release of Current Good Manufacturing Practices (CGMP) for dietary supplements by FDA. The global market, in fact, exhibited steady growth during the crisis-ridden period of 2008-2009 and beyond. The importance of healthy diet and good lifestyle dominated the minds of consumers, which could not be dampened even by the financial meltdown witnessed in almost every sector worldwide. In fact, the recession has actually prompted increased preference for dietary supplements. Escalating prices, tighter budgets and high healthcare and lifestyle costs, have actually driven consumers towards the more economical, healthier and safer option of alternative medicine and dietary supplements, to get relief from physical and mental disorders. ADDITIONAL POINTS COVERED: 1. Herbal Global Market. 2. Herbal Regional Market. 3. Herbal product category. 4. Global regulations for herbal market. 5. Marketing strategies used.

Biography:

Will be updated soon

Abstract:

India has immeasurable varieties of tropical plants. The Indian Medicine Central Council act 1970 recognizes Ayur-vedic medicine. Spices and herbs are recognized sources of natural antioxidants, many of which are phenols and aromatic amines..Clinical research has confirmed the efficacy of several medicinal plants for the treatment of many diseases including gastric disease. Basic scientific research has uncovered many of the mechanisms to explain their therapeutic effects The use of non steroidal anti-inflammatory drugs (NSAIDs) accounts for approximately 25% of gastric ulcer cases with an upward trend .The NSAIDs are one of the most widely prescribed drugs in the world.. However, these drugs are well known to induce stomach ulceration, and delay ulcer healing Therefore, development of a drug having antiulcerogenic property from plant sources without compromising the efficacy and safety would be expected to benefit millions of suffering humanity. With that object, we have selected for a study on antiulcer effect of the leaves of piper betle, camellia sinasis fruit of Myristica malabarica, roots of Picrroza kurrow of Indian origin with known therapeutic values against different diseases including gastropathy in Ayurvedic system of medicine. The present study also based on experimentally NSAIDs induced ulcer in animal model .Other than the antioxidative properties of these plants extracts but also have the property to up regulate the anti inflammatory cytokines e.g.,TGF-β, COX2,Growth factors e.g.,VEGF, PGE, Arginase, & vWF and down regulating the pro inflammatory cytokines e.g., TNF-α, IL1β,myloperoxidase level,COX1, endostatin, cellular adhesion molecules & selectins e.g.,s-ICAM,s-VCAM & Nitric Oxide etc. Regulating all the above mention parameters, it accelerates the healing of gastric ulcer and thus, the functional aspect of foods is due to their components present in.

Biography:

Babak Daneshfard is a PhDc at the age of 27 years in Shiraz University of Medical Sciences (SUMS). He has published more than 10 papers in reputed journals and has been serving as an reviewer of CAM journals. He is also an expert in Mind-Body Medicine.

Abstract:

Human body is an extremely complex system and it is so simplistic to think that an active agent working on a single receptor is enough for an optimal clinical response. There is a growing body of evidence shows the necessity for shifting to a multitarget approach in the field of drug discovery [1]. Traditional medicines which have holistic viewpoints in maintaining the overall balance of the body usually put forward such approach in their drug formulations as suggested in systems biology [2,3]. It may be the reason of recent more interest of pharmaceutical companies for research in traditional medicines [4]. Nonetheless, it has its own troubles; multicomponent formulations, possible toxicities, and lack of our knowledge regarding their mechanism of action are some of the obstacles. Understanding the concept of ameliorations –which means modulation of the effects and/or counteracting the side effects of ingredients of a compound formulation by one of its constituents– mentioned as Musleh in Traditional Persian Medicine and jun-chen-zuo-shi in Traditional Chinese Medicine, could pave the way for further researches in this field. Keywords: Drug discovery, Systems biology, Traditional medicine, Amelioration

Biography:

Will be updated soon!!

Abstract:

Traditional medicine is an important source of primary healthcare system in most rural communities in Nigeria. This high reliance on traditional medicine can be attributed to accessibility, local availability, affordability; existence of local knowledge and expertise and synergy with their cultural belief. However, the indiscriminate and non-systematic approach of harvesting by debarking is impacting on the availability of these species. Taxonomic index of these species and the implications of bark removal in five communities in Ebonyi State, Nigeria was carried out through oral interviews, field observation and focal group discussions with traditional healer and drivers of medicinal plants who are knowledgeable in that field were assessed. Results highlighted those flora families and taxa mostly affected to include Apocynaceae, Anacardiaceae, Longanaiceae Meliaceae, Rubiaceae Moringaceae, Bignoniaceae and Fabiaceae with its highest impact on Alstonia boonei, Anthocleista djarlonensis, Azadichrata indica, Khaya senealensis, Morinda lucida, Moringa oleifera, Nauclea latifolia and Anacarduim occindentale. Six out of these taxa are now rare, threatened or endangered with no policy program on the germsplam domestication and conservation. The medicinal uses of these medicinal plants and implication of debarking on sustainable conservation are discussed. Keywords: Debarking, herbals, exploitation, sustainability, Nigeria

Biography:

Shujaul Mulk khan is Assistant Professor of Plant Sciences, Quaid-i-Azam University Islamabad Pakistan. He did his PhD from University of Leicester, UK followed by a Post doc from the same University. He has distinctions in his academics. His fields of specializations are Plant Ecology, Biodiversity Conservation, Vegetation Modelling, Ecosystem Services, Ethnobiology and Syntaxonomy. He has published numbers of books and journal articles in reputed journals. He has supervised numbers of students at PhD, MPhil and MSc level. He is member of editorial team and reviewer of numbers of journals and member of scientific journal.

Abstract:

Interaction between plants and people is much stronger in remote tribal societies all over the world. District Tor Ghar is one of such remote and rugged mountainous region of the extreme western Himalays that has historically long established tribal culture. The district is occupied by 5 main tribes namely Basikhel, Nusratkhel, Akazai, Hassanzai and Medakhel. A total of 43 villages from all tribal belts were randomly selected by using random table number method. Every Third house was selected on willingness basis. Local wisdom of 732 informants of all age groups including males and females was explored first time by standard ethnobiological protocol. Information about 295 ethno species utilized by five tribes for 33 cultural use categories was gathered via semi structured interviews, group discussions, EPA and extensive field visits. Cultural uses among different tribes were categorized by using modern software computer package PCORD version 5.1 for TWCA. All 33 cultural use categories were grouped in to 11 sub clusters among five tribes. These 11 sub clusters were further organized in to two main clusters. One main cluster comprised of Basikhel and Nusrat khel tribes sharing maximum use categories whereas the second main cluster represented highest number of common use categories among Akazai, Hassanzai and Medakhel tribes. Handling of cultural data through modern software packages is first ever attempt in the region.