Kang Saeromi
Pusan National University, Republic of Korea
Title: Triterpenoid saponin PGM induced M2 polarization of macrophages and fastened resolution of peritonitis in vivo
Biography
Biography: Kang Saeromi
Abstract
Triterpenoid saponins (TS) are the most active ingredients of Korean red ginseng, especially in steamed ginseng root. Anti-inflammation, anti-tumor, and anti-oxidant activities of TS have been reported in relationship with many health benefits. Resolution phase of inflammation has recently been recognized as an active process derived by specialized pro-resolving mediators. Those mediators are supposed to be produced by M2 type-polarized macrophages. Among tested TS, PGM was found as the most active saponin inducing M2 polarization of macrophages. Furthermore, PGM not only induced expression of M2 marker genes, such as arginase-1, but also influenced M1 marker genes, such as inducible nitric oxide synthase and cyclooxygenase-2. Resolution promoting activity of PGM was investigated in vivo in a murine zymosan-induced peritonitis model. PGM fastened the resolution process, when it was intraperitoneally injected at the peak inflammatory response in the peritoneal cavity. These results suggest that PGM induced M2 polarization in macrophages and thereby resolved the inflammation faster. KEY WORDS: Resolution, ginseng, triterpenoid saponin, inflammation