Babar Ali
College of Pharmacy and Dentistry, Buraydah Colleges, KSA
Title: Isolation and characterization of two new glycosides from black cumin
Biography
Biography: Babar Ali
Abstract
Black cumin (Nigella sativa Linn.) belongs to family Ranunculaceae and commonly known as Kalajira and Kalonji. Black cumin has volatile oils, various esters of unsaturated fatty acids with terpene alcohols, isochinoline and pyrazol alkaloids. Objective of this work is to isolate different compounds from the methanol extract of Nigella sativa seeds. Different compounds were isolated with column chromatography. The column was eluted with petroleum ether, chloroform, methanol and their combinations in order of increasing polarity to isolate the compounds.Two new glycoside, decanyl nigelloic acid diglucoside, n-decanyl-3- aldehydic-4-methoxy-5-hydroxy benzoyl-5-β-D-glucofuranoyl-(2→1)-β-D-gluco pyranosyl-(2→1)-β-D glucopyranoside) and nigelabdienoyl triglucoside, homolabd- 5, 9 (11) -dien-16-onyl-β-D-glucopyranosyl (2→1)-β-D-glucopyranosyl (2→1)-β-D- glucopyranoside along with other seven known compounds were isolated from the seeds of black cumin. The structure of these new glycosides were elucidated and established by standard spectroscopic methods. Total nine compounds were isolated from the extract in which two new glycosides were isolated for the first time from the plant.