Day 2 :
- Herbals in Cancer Therapy
Pharmacognosy and Phytochemistry
medicinal and aromatic plants
Mindfullness
Acupunture
Session Introduction
Mukesh S. Sikarwar
AIMST University, Malaysia
Title: Commercializing breadfruit (buah sukun) as nutraceutical for food and nutrition
Biography:
Dr. Mukesh Singh Sikarwar is currently working as Senior lecturer in Faculty of Pharmacy, AIMST University, Malaysia. He received his PhD in Pharmacy from K.L.E. University, Belgaum India in year 2011. His current area of research is herbal antioxidants, antidiabetics and antihyperlipidemics, novel drug delivery in herbal drugs, formulation and evaluation of herbal drugs and food safety. He has more than 10 year of experience in mentoring students in Pharmacognosy and chemistry subjects. He has published 53 research and review papers in various peer reviewed internationals and national journals and also serving as reviewer for many international journals. He has presented 23 research papers in various national and international conferences. He has attended many MOOC courses and Online CME from online learning programmers. He is a life member of APTI, member of Asian Council of Science Editors, annual member of Society for Ethnopharmacology, India and registered as pharmacist with M. P. State Pharmacy Council.
Abstract:
Breadfruit has potential for food and nutrition security and sustainable production in the tropics especially in Caribbean and ASEAN countries but it is under-utilised and commercial production is limited. It is rich source of nutrients and used as replacement for wheat and possess medicinal properties hence it has potential to be sold as nutraceutical. Artocarpus altilis (Family: Moraceae) is commonly referred to as breadfruit as the texture of the moderately cooked ripe fruit flavors like potato or similar to freshly baked bread. In Malaysia, breadfruit is called buah sukun and its popular Malaysian recipe is halwa Sukun. Other recipes include boiled Breadfruit in coconut milk, Breadfruit curry, sukun chips, sukun fritters (cekodok sukun), soup and fish cakes. Over 130 phyto-compounds especially flavonoides and polypheols are identified in various parts of breadfruit plant. Nutritional compositions includes protein, carbohydrate, fat, calcium, phosphorus, K, iron, niacin, thiamine and vitamin C. Keeping above information in consideration nuratceutical product of soft gel capsules for breadfruit powder extract can be prepared and characterize for its marker compounds and antioxidant potential. It can be used as main source of antioxidant and will have application in treatment of oxidative stress caused by diabetes, inflammation, cancer and many such diseases. It can also be replacement for wheat flour, Gluten free, GMO free without trans-fat, Keywords: Breadfruit, Nutraceutical, food and nutrition
Azza H. El-Medany
Alexandria University, Egypt
Title: Expanding the therapeutic utility of curcumin “An experimental study on DMH-induced colorectal cancer.â€
Biography:
Azza Hafiez El-Medany has completed her PhD and Postdoctoral studies from Alexandria University, College of Medicine, Egypt. She is the Professor of Pharmacology & vice Head of the Department of Pharmacology, College of Medicine, KSU. She has published more than 40 papers in the areas of GIT, CVS, natural products & toxicological researches in reputed journals and serving as a member of number of professional bodies. She is the recipient of special awards in scientific research & teaching.
Abstract:
In search for drugs that can target cancer cell microenvironment in as much as being able to halt malignant cellular transformation, the natural dietary phytochemical curcumin was currently assessed in DMH-induced colorectal cancer rat model. The study enrolled 50 animals divided into a control group (n=10) and DMH-induced colorectal cancer control group (n=20) (20mg/kg.-body weight for 28 weeks) versus curcumin-treated group (n=20) (160 mg/kg suspension daily oral for further 8 weeks). Treatment by curcumin succeeded to significantly decrease the percent of ACF and tended to normalize back the histological changes retrieved in adenomatous and stromal cells induced by DMH. The drug also significantly elevated GSH and significantly reduced most of the accompanying biochemical elevations (namely MDA, TNF-α, TGF-β & COX2) observed in colonic carcinomatous tissue, induced by DMH, thus succeeding to revert that of MDA, COX2& TGF-β back to near normal as justified by being non-significantly altered as compared to normal controls. The only exception was PAF that was insignificantly altered by the drug. When taken together, it could be concluded that curcumin possess the potentiality to halt some of the orchestrated cross-talk between cancerous transformation and its microenvironmental niche that contributes to cancer initiation, progression and metastasis in this experimental cancer colon model. Envisioning these merits to a drug with an already known safety preferentiality, awaits final results of current ongoing clinical trials, before curcumin can be added to the new therapeutic armamentarium of anticancer therapy.
Biography:
Farheen Fatima has completed her PhD and serving as an assistant professor, teaching diagnostic microbiology and diagnostic parasitology. She did her post-graduation studies specializing in medical microbiology from one of the most reputed university- Manipal Academy of Higher Education, India. She conferred a doctorate degree in medical microbiology from Vinayaka Mission University, Salem. She has worked as a principal investigator in epidemiologic surveys centering microbial and co-investigator in sero-epidemiology and parasitic infections in children. She has extended my work in biochemical contents of microbes. As of the moment she is working with the desert herbs to explore their individual and synergistic antimicrobial potential.
Abstract:
DiallylDisulphide (DADS) is a phytochemical found in the plants of the genus Allium. It is the principal organosulphuric component of distilled garlic oil. Many medicinal benefits like antimicrobial, antiviral and insecticidal are attributed this compound. However the biochemical explanation for such an action remains unexplored. This current study strives to explore the explanation for antimicrobial activity of the compound using the most common skin inhabitant Gram positive bacteria, commonly causing nosocomial infections- Staphylococcus aureus. The Minimum Inhibition Concentration(MIC), Minimum Bactericidal (MBC) Concentration of DADS, its effect on growth curve and time kill curve of S.aureushas been established. In the current study S.aureus was cultured in the broth containing 1/8 MIl analytic tests. The biochemical components focused on were of those abundantly present and those that contribute to the materializC of DADS. The staphylococcal cells were harvested; biochemical components were extracted and quantitated using appropriate biochemicaation of the staphylococcal cell envelope total lipids, total lipid phosphorous and total carbohydrates. The biochemical component extracts of S.aureustested revealed significant reduction in the total lipids (70%), total lipids phosphorous (50%) and total carbohydrates (34%). This reduction in the components may be attributed to the hypolipidemic and hypoglycemic properties of DADS and could further lead to changes in the anabolic processes. Since the cell envelope of the bacterial cell is primarily made up of lipids, phospholipids and peptidoglycan (a carbohydrate polymer). The evident reductions in the studied components indicate reflective impact of DADS on the cell envelope of S.aureus. This study can be extrapolated in innovation of a new phytochemical-antibiotic against the life threatening multidrug resistant human pathogens.
Suad Yousif Abdalla Alkarib
University of Karary, Sudan
Title: Correlation of gum acacia with serum electrolytes among patients with stage 3 renal disease
Biography:
Suad Yousif Abdalla Alkarib has completed her PhD from University of Khartoum, Sudan. She is the Founder of College of Pharmacy in Karary University. Earlier she was the Director General Manager for the “Wafrapharma Laboratories Ltd. for drug manufacturing. She is the Member of the Sudanese Medical Council, Scientific Researches committee in Gum Arabic Board, Sudan, Arab Administrative Development Organization (League of Arab States). She is the Rapporteur of the Industrial Pharmacy Committee in the Pan Arab Colleges of Pharmacy. She is the Member of the proposed fellowship in Technology of Industrial Pharmacy (Council of pharmaceutical specialties, Sudan). She has published more than 15 papers in different journals and conferences.
Abstract:
Introduction: Gum arabic acacia is a complex, loose aggregate of sugars and hemicelluloses composed of Arabic acid nucleus, it is found in nature and exists as a natural or slightly acidic calcium, magnesium, potassium or sodium salt of complex polysaccharide and the different metal ions present in gum arabic molecules, Chemically, it is an arabinogalactan protein complex composed by weight of 17-34% arabinose, 32-50% galactose, 11-16% rhamnose, 13-19% glucuronic acid and 1.8-2.5% protein. Serum electrolytes play specific roles in optimization of the blood pressure and hence the kidney functions. Methodology: It is a randomized control trial study, it was performed using (14) volunteers with different blood pressure readings and different kidneys function with six months past history. Dose of 10,15,20 and 25 grams of gum dissolved in 250 ml drinking water to be taken at the morning, were used for a duration of 16-18 weeks with interval every four weeks for every dose. Blood samples were taken for electrolytes analysis first as a control and after every interval before starting the next dose and the blood pressure was read after every interval. Results: The electrolytes levels showed biological rearrangement optimized referenced readings and hence the blood pressure both systolic and diastolic at a dose ranges 20-25 gm. Conclusion: There is a significant correlation between Gum acacia and electrolytes control in blood serum and hence the blood pressure, this depends upon the different Gum components ratios.
Erna Sulistyowati
Kaohsiung Medical University, Taiwan
Title: Decoction of Centella asiatica, Justicia gendarussa, and Imperata cylindrica Protect Heart by Oxidative Stress Diminution on Spontaneous Hypertensive Rats
Biography:
Erna Sulistyowati has been puersuing her Ph.D program at Kaohsiung Medical University, Taiwan since 2014. She is either a medical doctor and lecturer at Faculty of Medicine, University of Islam Malang Indonesia. She has been doing research about herbal medicine related to cardiovascular system. She also has already got doctor’s clinical licence in Indonesian traditional practice (Dokter Praktek Jamu). She has published more than 12 papers in Indonesian journals. Recently she is doing herbs-medicine research as a part of scientific program of jamu in Indonesia traditional medicine.
Abstract:
Most of Indonesian rural community use decoction extract of Centella asiatica (L.) Urban (C), Justicia gendarussa (J) and Imperata cylindrica (I) to treat hypertension. This study purposed to get its rational form in lowering blood pressure and its effect on heart tissue prevention through oxidative stress inhibition. This experimental laboratory study divided 30 males (180-200 g) Wistar Kyoto rats and Spontaneous Hypertensive rats (SHR) into two groups, control (CTL) (aquadest) and treatment group (oral administered decoction of C (9 mg), J (9 mg), and I (5,4 mg)), once daily for 5 weeks. Weekly observation on systolic blood pressure (SBP), heart rates, metabolic profiles (body weight, food consumption, drinking water, urine volume and stool weight). Echocardiography examination were taken before sacrifice. Oxidative stress assays were measured on serum and heart tissue lipid peroxidation and reactive oxygen species (ROS). Treatment group showed lowering weekly systolic blood pressure on spontaneous hypertensive rat (SHR) respectively (p<0.01) and slower heart rates compared to SHR CTL group (p<0.05). There were no changes in metabolic profiles among all groups. Treatment group had increased in left ventricular heart fractional shortening (FS) and ejection fraction (EF) on SHR group (p<0.01). Treatment group demonstrated diminished serum (p<0.001) and heart tissue (p<0.01) malondialdehyde, anion superoxide and hydrogen peroxide generation on SHR group (p<0.01). Given decoction extract of CJI lowered SBP and protected heart by oxidative stress diminution on SHR. These findings suggest that CJI has potential therapeutic in the treatment of hypertension. Keyword: Centella asiatica (L.) Urban, Justicia gendarussa, Imperata cylindrica, decoction, oxidative stress, hypertension
Nguyen Thi Trieu
Independent Physician, Vietnam
Title: Tenofovir Disoproxil Fumarat , Herbal Medicaments, Vitamin C Treatment on HBeAg Positive or HBeAg Negative in Chronic Hepatitis B (HBV)
Biography:
Physicians Trần Minh Äức & Nguyá»…n Thị Triệu from Vietnam, they are pursuing a combination of natural herbal and medicinal artificially to create a new breakthrough towards helping improve the quality of life. They are rediscovering nature and nurture as safer in treatment, cost effective health and healing resources
Abstract:
Phyllanthus Cantoniensis Hornem - Herba Adenosmatis Caerulei - Herba Eclipta - Vitamin C combination plus Tenofovir in treatment of acute and chronic hepatitis B. Method the combination of drugs derived from natural and artificial medicaments. Has stronger effect on immune system, effective good against HBV replication. This is a substantial new insight into the pathogenesis of disease, with a clear path toward clinical application, or which would lead to a substantial advance and perfect in management or public health policy. Triple
Arunabha Ray
University of Delhi, India
Title: Adaptogenic effects of some medicinal plants: integration of traditional and modern concepts
Biography:
Arunabha Ray holds an MD and a PhD and is the Chair, Department of Pharmacology at the Vallabhbhai Patel Chest Institute, Faculty of Medicine, University of Delhi. He has more than 36 years teaching and research experience in basic and clinical pharmacology and toxicology and has been the recipient of several awards and honors for research excellence. He has more than 150 research publications, is Author of several text and reference book chapters, Editor of 04 books in his areas of expertise, and Author of a textbook in pharmacology.
Abstract:
Stress related disorders contribute to a significant proportion of global illnesses and adaptogens are herbal agents which have the potential to attenuate stress effects. Since its inception, the concept of adaptogens has evolved considerably and newer mechanisms have been proposed. As these agents have to be administered for a reasonably long period of time, the benefit versus risk ratio is important and herbal agents are definitely preferable over their synthetic counterparts. The brain, HPA axis and immune system play a crucial role in the expression of the stress response and studies were conducted to evaluate the possible interactive mechanisms in the adaptogenic effects of some herbal agents. The role of CNS-neuroendocrine-immune interactions during the adaptogenic effects of agents like Ocimum sanctum (Tulasi, OS), Azadirachta indica (Neem, AI) and Withania somnifera (Ashwagandha, WS), used in traditional medicine, were investigated in experimental animals. Restraint Stress (RS) was used as the experimental stressor, and the effects of RS and their modulation by OS, AI and WS extracts were assessed in albino rats. RS suppressed neurobehavioral (elevated plus maze test), endocrinal (plasma corticosterone) and immune (humoral and cell mediated) responses – effects that were differentially reversed by OS, AI and WS pre-treatments. Herb-drug interaction studies showed that endogenous neuromodulatory substances could be involved in the observed adaptogenic effects. Such interactive studies are of great significance for the convergence of traditional and modern medicinal concepts and for the development of newer, more effective and safer herbal agents for the treatment of stress related disorders.
Achintya Kr. Deb
Rajiv Gandhi University of Health Sciences, India
Title: TUMPE- Therapeutic uses of medicinal plants in panchakarma treatment to promote eco- tourism.
Biography:
Achintya Kr. Deb has completed his MD in Panchakarma from Rajiv Gandhi University of Health Sciences, India. He is the Medical Director of Panchakarma Research & Training Centre Tripura, a leading institute of India under The Forest Department, Govt. of Tripura. He has attended many national and international seminars to promote Herbal system of medicine. He has also published more than 20 papers in books and journals. He is serving as an expert in Medicinal Plants Board of Tripura, under National Medicinal Plants Board of India.
Abstract:
Herbal remedies have been the most popular worldwide throughout the last decade. Herbal medicines are being used to treat the diseases as well as to maintain the health of healthy persons. Phytochemical analysis of plants reveals the active components which are responsible to fight against the pathogens in a better way than the synthetics. Further research work is very much essential to know the mode of action of the Herbal medicines that enhance the immune system of body to fight against the diseases. Panchakarma treatment, a glory of Ayurveda - Indian system medicine is being practiced in India since thousands of years where Herbal plants and medicines are used to expel out toxins from human body in a natural way to make person disease free and also to keep him healthy both physically and mentally. ‘Pancha’ means five and ‘Karma’ means procedures, these are: - Vamana, Virechana, Basti, Nasyam and Raktamookshana. They help to expel out toxins from the body through Mouth, Anal and Nasal route, and Skin pores Eco-tourism; means development of Tourism keeping in view the environment and local culture intact, the concept of Panchakarma treatment modality strongly supports the developmental activities of Eco-tourism in Tripura, India. Eco-tourism activities of Tripura are well developed and have touched too many milestones, and people throughout the world have been interested to have the benefit of Panchakarma for better living. Further scope of development in Eco-tourism and Health-tourism remains as The Govt. of India and Tripura have taken very good initiative to develop the above sectors.
Akkal Salah
University of Constantine, Algeria
Title: Phytochemical constituents of aerial parts of an endemic species of region arid from the Apiaceae of Algeria
Biography:
Salah Akkal has completed his PhD at the age of 39 years from Constantine University. He was supervised on 4 M.Sc. thesis and 8 Ph-D. He is professor for natural product chemistry since 2007 in Chemistry Department, Faculty of science. He has published more than 70 papers in reputed journals and has been serving as an editorial board member of repute and has been serving as a reviewer for many articles in her specialization. He attended more than 15 International Conferences He teaching all the organic chemistry and natural product courses for the students of Faculty of Science and Faculty of Technology in University of Constantine, Algeria
Abstract:
The Apiaceae family is represented in Algeria by 28 genus and 146 species. Among this family, many plants of the genus are widely used in local herbal medicine, as they show a wide range of pharmacological activities. Many species of Apiaceae were used in folk medicine, as spices in cookery, but also as official medicinal drugs [1, 2].Thus, they account as a well-known source of essential oils and important herbal products. They are included in various pharmacopoeias as antiseptic, expectorant, diuretic, carminative, vasodilator, or spasmolytic agents [3]. The purpose of this research concerns the phytochemical and the biological study of of some genus of the Algerian flora’s medicinal plants known as Return, Formula, Bupleurum, Daucus. The diverse methods of separation and purification of the methanolic extract of these plants to obtain many constituents. Many compounds belonging to different classes of secondary metabolites were isolated for the first time from the aerial parts of some species. These include flavonoids, coumarines, terpenoides an epoxide and a sugar which contributed to the diversity of natural products in the species. The structure elucidation of the isolated compounds was based on analyses of their spectroscopic data (1D and 2D NMR, UV, MS). Structure elucidations of the phytoconstituents were achieved using various spectroscopic methods such as 1D (1H, 13C) and 2D (COSY, HMQC, HMBC, NOESY) NMR, MS, IR and UV-Vis and by comparison of their data with those of published compounds. Analyses of the extracts by gas chromatography and GC-mass spectrometry (GC-MS) tentatively identified many compounds, the various extracts and isolated compounds of this species were studied for their antioxidant and antimicrobial activities. The isolation of these biological active compounds showed the real importance to investigate plants that can be sources of new compounds with clinical activities [4]. Keywords: Apiaceae, phytochemical study, essential oils, antimicrobial and antioxidant activity.
Babar Ali
College of Pharmacy and Dentistry, Buraydah Colleges, KSA
Title: Isolation and characterization of two new glycosides from black cumin
Biography:
Babar Ali has completed his Ph.D at the age of 30 years from Faculty of Pharmacy, Jamia Hamdard, New Delhi, India. He has five years teaching and research experience in the field of pharmaceutical sciences. Currently he is working as associate professor and head of department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy and Dentistry, Buraydah Colleges, Al-Qassim, Kingdom of Saudi Arabia since 2012. He has published more than 25 national and international papers and is serving as an international editorial board member of reputed journal.
Abstract:
Black cumin (Nigella sativa Linn.) belongs to family Ranunculaceae and commonly known as Kalajira and Kalonji. Black cumin has volatile oils, various esters of unsaturated fatty acids with terpene alcohols, isochinoline and pyrazol alkaloids. Objective of this work is to isolate different compounds from the methanol extract of Nigella sativa seeds. Different compounds were isolated with column chromatography. The column was eluted with petroleum ether, chloroform, methanol and their combinations in order of increasing polarity to isolate the compounds.Two new glycoside, decanyl nigelloic acid diglucoside, n-decanyl-3- aldehydic-4-methoxy-5-hydroxy benzoyl-5-β-D-glucofuranoyl-(2→1)-β-D-gluco pyranosyl-(2→1)-β-D glucopyranoside) and nigelabdienoyl triglucoside, homolabd- 5, 9 (11) -dien-16-onyl-β-D-glucopyranosyl (2→1)-β-D-glucopyranosyl (2→1)-β-D- glucopyranoside along with other seven known compounds were isolated from the seeds of black cumin. The structure of these new glycosides were elucidated and established by standard spectroscopic methods. Total nine compounds were isolated from the extract in which two new glycosides were isolated for the first time from the plant.
Laxmi Narain Misra
CSIR- Central Institute of Medicinal and Aromatic Plants, India
Title: Recent advances in validation of bioactivities of steroidal compounds in ashwagandha (Withania somnifera) the Indian Ginseng
Biography:
Misra completed his Ph D in 1981 and got opportunity to work in the renowned groups of natural product chemistry: with Prof. F. Bohlmann, Technical University, Berlin (1982-84), Prof. H. Wagner, LM University, Munich (1991-92 and 1999-2000), Prof. H. Laatsch, GA University, Goettingen (1998), Prof. M. Pischetsrieder, FA University, Erlangen (2009- 10), besides the parent institute, the CSIR- CIMAP, Lucknow. He has published about 110 research papers in reputed international journals of medicinal and aromatic plants and has protected the promising inventions by filing suitable patents. He has recently retired from the position of Chief scientist and Head of Chemical Sciences Division of CSIR-CIMAP, Lucknow, India.
Abstract:
Traditional medicine has been an integral part of Asian society for centuries and a fresh interest in medicinal plants was revived in 1980s, when the harmful effects of synthetic drugs started surfacing. Now, people rely more on herbal drugs because of high prices and harmful side effects of synthetic drugs. It has become fast driven social phenomenon to depend upon the herbal products or traditional medicines prescribed by the practitioners of indigenous systems of medicine, viz. Ayurveda, Unani, Siddha, Homoeopathy, etc., in India and similar traditional systems of medicines, viz. TCM, etc., world over. With the increasing popularity and awareness of herbal drugs, the role of natural product chemists has significantly increased. Now, it has become necessary to study the detailed chemical components of established medicinal plants and develop their chemical profile to monitor the authentic presence in the herbal preparations and regulate their uses. Also, the invention of new natural sources of biologically active compounds, especially, from the waste materials, opens up further scope, in this direction. Isolation of new compounds with unusual chemical structures adds to the existing knowledge on structure elucidation and chemical dictionary for further use by medicinal chemists. In the present lecture, it is proposed to give examples of isolation of bioactive withasteroides from Withania somnifera, the Indian ginseng which is invariably used in about 90% of herbal products of India. The validation of most of the bioactivity in this plant has been done to show that they are associated mainly with the steroidal molecules present in it.
Kavita Gulati
University of Delhi, India
Title: Translational research and herbal drug development: An experience with bronchial asthma
Biography:
Kavita Gulati holds a PhD and is a Professor in the Department of Pharmacology at the Vallabhbhai Patel Chest Institute, University of Delhi. She has more than 25 years teaching and research experience in basic and clinical pharmacology and herbal drugs and has been the recipient of several awards and honors for research excellence. She has more than 80 research publications, is Author of several text and reference book chapters, Co-Editor of 4 books in pharmacology.
Abstract:
Herbal drugs are emerging as viable alternatives for complex disease states and modern scientific methodology are being adopted to validate the effects of such agents used in the traditional systems of medicine. Translational research in medicine is a two-way street and aims at breaking down barriers between clinical and basic medical sciences to promote rapid transfer of knowledge from bench to bedside and vice versa. In pharmacological sciences and drug development, this concept is being utilized for accelerating the conversion of basic and/or clinical research findings to sustainable health care solutions. Bronchial asthma is a chronic inflammatory respiratory disorder with steroid dependent pharmacotherapy and the use of herbal agents is being explored in search of viable alternatives. UNIM-352 is a poly-herbal formulation, used in traditional medicine for bronchial asthma, and clinical and experimental studies were conducted to validate their observed effects. In the clinical study, UNIM-352 significantly enhanced the therapeutic effect of standard anti-asthma therapy as assessed lung function tests and symptomatology, as compared to the placebo group, indicating its efficacy as an adjunct therapy. In the experimental study, UNIM-352 demonstrated differential degrees of anti-inflammatory, immune-modulatory, broncho-relaxant, anti-remodeling, and antioxidant effects in rats, by using well established biomarkers for the above pathophysiological states. The results indicate that this poly-herbal agent could be used as an alternative/adjunct in the treatment of bronchial asthma. This study also highlights the importance of a translational approach in herbal drug research which could rationalize drug therapy of complex diseases.
Mohamed Suleiman
King Khalid University, KSA
Title: An ethnobotanical survey of medicinal plants used by communities of Northern Kordofan region, Sudan
Biography:
Suleiman has completed his PhD in the year 2009 from Al-Neelain University, Khartoum, Sudan. He has published more than 5 papers in reputed journals and has been supervised more than 10 MSc. Thesis.
Abstract:
Ethnopharmacological relevance: The present study provides significant ethnopharmacological information on plant species used in North Kordofan region, western Sudan. The study was undertaken with an aim to document the medicinal uses of the species known to some Northern Kordofan communities. Material and methods: The study was conducted between 2012 and 2013. The plants were identified and voucher specimens prepared. Information was collected by means of semi-structured interviews with 258 informants (195 men and 63 women). In addition, the use value (UV) of the species was determined and the informant consensus factor (ICF) was calculated for the medicinal plants researched in the study. Further analysis was carried out to compare results with previous studies from the study area and other regions of Sudan. Results: A total of 44 plant species representing 24 families were found to be commonly used in the treatment of 73 different human health problems. The families most represented were Leguminosae (18%), Caesalpiniaceae (9%), Malvaceae (9%), Asclepiadaceae (6.8%) and Combretaceae (6.8%). The highest number of plant species are used against digestive system disorders (23 species) followed by microbial infections (21 species) and dermatology (19 species). Among all the plant parts leaves (20%), roots (19%), fruits and bark (14% each) were the most preferred plant parts used by the informants. There was strong agreement among the informants as to the usages of the plants (informant consensus factor 0.63-0.93). The most important plants on the basis of use-value were Acacia nilotica, Acacia seyal, Balanites aegyptiaca, Cassia occidentalis, Cassia senna, Guiera senegalensis and Tamarindus indica. Conclusion: This study has helped to document information that may otherwise be lost to future generations. This is the first ethnobotanical study in which statistical calculations about plants are carried out by means of the ICF and UV methods in the study area. Plants with high ICF and UV values should be subjected for further phytochemical and pharmacological investigation for scientific validation.
Biography:
Tanveer Alam was born in Bijnor, India on 21st Jan. 1974. He received his Ph.D. Degree in the field of Natural Product Chemistry from Jamia Hamdard, New Delhi, India in 2001. From Nov. 2000 to Sept. 2001, he was a Research Associate at Jamia Hamdard, New Delhi, India and worked on synthesis of water soluble derivatives of Silymarin. Upon completion of his education, he started his career as an Executive-R&D in a Flavour & Fragrances Company and after words he had served as Manager & Head-R&D in different National & Multinational Herbal Industries. Dr. Alam has more than 15 years of R&D experiences in the field of Natural Products. He has been worked as Associate Professor in Eritrea Institute of Technology, State of Eritrea. He is Ph.D. supervisor in JJT, University, Rajasthan, India and Advisor in Natural Food Colours Industry. He is also a Member of Editorial Boards and Referee for more than Eight National & International Journals. Since March 2015, Dr. Alam is looking the Production Unit for commercialization of Omani Medicinal & Aromatic Plants at University of Nizwa, Sultanate of Oman.
Abstract:
The worldwide demand for natural colors is nowadays of great interest due to the increased awareness on the therapeutic properties of natural colors in public. Natural colors are derived from naturally occurring sources such as plants, insects, animals and minerals. Several synthetic colorants have been banned because they cause allergy-like symptoms or are carcinogens. Among the all-natural colors, plant-based pigments have wide range of medicinal values. The present topic, describes the detail information about chemistry of the major pigments and their medicinal importance found in naturally occurring color yielding plants and animals, which are helpful to further development of pharmaceutical formulation. Keywords: Natural food color, water soluble, extraction, pigments.
Maria Theresia Darini
Agriculture Faculty Sarjanawiyata Tamansiswa University, Indonesia
Title: The responce of growth, yield and antioxidant contents of Aloe vera L. plant on a combination dosage of fertilizers in sandy soil
Biography:
Maria Theresia Darini has completed her PhD and currently working as an professor at Agriculture Faculty Sarjanawiyata Tamansiswa University, indonesia. she as published more than 10 papers in international journals and attend many international conferences world wide.
Abstract:
The study aims to explore the response of growth, yield and antioxidant content of Aloe vera plant in sandy soil which is marginal land to need added of fertilizer dosage combination to improve fertility. The experiment was conducted in the districts of Bantul sandy soil Special Region of Yogyakarta, crop production laboratory Sarjanawiyata Tamansiswa University and Research and Test Integrated Laboratory Gadjah Mada University. The research was arranged in a Randomized Complete Block Design factorial with three replications. The first factor dosage of manure, namely 10, 20 and 30 tons ha-1. The second factor dosage of urea fertilizer namely 0; 150; 300; 450 and 600 kg ha-1. Variable of observations include the components of growth, yield and antioxidants content. Analysis of the results using analysis of variance on a significant level of 5 % , followed by Duncan 's Multiple Range Test at the 5% significance level. The conclusion was interaction between manure and urea fertilizer dosage on all of variable observation. The growth and yield highest obtained on addition manure 30 ton ha-1 and urea 450 kg ha -1. Antioxidant content highest obtained addition manure 20 ton ha-1 and urea 30 kg ha-1. Keyword; Aloe vera, antioxidant, manure, sandy soil, urea
Biography:
Bhushan Bhavsar is the founder and Managing Director of the Company. He has worked for more than a decade into the herbal and food supplement industry. His knowledge and expertise into the industry is well respected and proven into the field of product development, regulations, research, manufacturing, packaging & designing, marketing, sales and logistics, collectively said to be providing all the services under one roof to set up your business Nationally and Internationally. Due to his full devotion and work towards Ayurveda, Dr. Bhavsar has been chosen as President of World Ayurveda Health Organization (WAHO) working currently in 9 countries – India, Switzerland, United Kingdom, The Netherlands, Belgium, Germany, U.A.E., Brazil and Canada. As an innovative product researcher, Dr. Bhavsar has found many proven solutions for various lifestyle diseases and holds product and design patents. Graduated as B.A.M.S. (Bachelor in Ayurvedic Medicine & Surgery) and M.B.A. (Healthcare & Hospital Management) with a Gold Medal, Post Graduate Diploma in Cosmetic Technology and L.L.B. (Bachelor Of Legislative Law) (Honors). Awarded twice with Gold Medal for ‘Best Business Strategic Planner’ and ‘The Entrepreneur’s Award’.
Abstract:
The global herbal supplements and remedies market is forecast to reach $107 billion by the year 2017, spurred by growing aging population and increasing consumer awareness about general health and well being, according to a new report from Global Industry Analysts. Additionally, the fact that herbal supplements and remedies cause little or no side effects and provide greater efficacy is also proving to be a major factor aiding market growth. The global herbal supplements and remedies market exhibited robust growth over the last decade, with little or no significant decline on account of the recent economic recession. The factors that fueled growth in the market include widespread acceptance of functional foods, rise in consumer confidence to include herbs in preventive health and alternative medicine regimens, supplier innovations, and the much awaited release of Current Good Manufacturing Practices (CGMP) for dietary supplements by FDA. The global market, in fact, exhibited steady growth during the crisis-ridden period of 2008-2009 and beyond. The importance of healthy diet and good lifestyle dominated the minds of consumers, which could not be dampened even by the financial meltdown witnessed in almost every sector worldwide. In fact, the recession has actually prompted increased preference for dietary supplements. Escalating prices, tighter budgets and high healthcare and lifestyle costs, have actually driven consumers towards the more economical, healthier and safer option of alternative medicine and dietary supplements, to get relief from physical and mental disorders. ADDITIONAL POINTS COVERED: 1. Herbal Global Market. 2. Herbal Regional Market. 3. Herbal product category. 4. Global regulations for herbal market. 5. Marketing strategies used.
Sandip K Bandyopadhyay
KPC Medical College & Hospital, India
Title: Herbal remedy: An alternate therapy of NSAIDS-induced gastric ulcer healing
Biography:
Will be updated soon
Abstract:
India has immeasurable varieties of tropical plants. The Indian Medicine Central Council act 1970 recognizes Ayur-vedic medicine. Spices and herbs are recognized sources of natural antioxidants, many of which are phenols and aromatic amines..Clinical research has confirmed the efficacy of several medicinal plants for the treatment of many diseases including gastric disease. Basic scientific research has uncovered many of the mechanisms to explain their therapeutic effects The use of non steroidal anti-inflammatory drugs (NSAIDs) accounts for approximately 25% of gastric ulcer cases with an upward trend .The NSAIDs are one of the most widely prescribed drugs in the world.. However, these drugs are well known to induce stomach ulceration, and delay ulcer healing Therefore, development of a drug having antiulcerogenic property from plant sources without compromising the efficacy and safety would be expected to benefit millions of suffering humanity. With that object, we have selected for a study on antiulcer effect of the leaves of piper betle, camellia sinasis fruit of Myristica malabarica, roots of Picrroza kurrow of Indian origin with known therapeutic values against different diseases including gastropathy in Ayurvedic system of medicine. The present study also based on experimentally NSAIDs induced ulcer in animal model .Other than the antioxidative properties of these plants extracts but also have the property to up regulate the anti inflammatory cytokines e.g.,TGF-β, COX2,Growth factors e.g.,VEGF, PGE, Arginase, & vWF and down regulating the pro inflammatory cytokines e.g., TNF-α, IL1β,myloperoxidase level,COX1, endostatin, cellular adhesion molecules & selectins e.g.,s-ICAM,s-VCAM & Nitric Oxide etc. Regulating all the above mention parameters, it accelerates the healing of gastric ulcer and thus, the functional aspect of foods is due to their components present in.
Babak Daneshfard
Shiraz University of Medical Sciences, Iran
Title: Introducing the concept of Musleh (Ameliorating agent) as a key point for drug discovery in traditional medicines
Biography:
Babak Daneshfard is a PhDc at the age of 27 years in Shiraz University of Medical Sciences (SUMS). He has published more than 10 papers in reputed journals and has been serving as an reviewer of CAM journals. He is also an expert in Mind-Body Medicine.
Abstract:
Human body is an extremely complex system and it is so simplistic to think that an active agent working on a single receptor is enough for an optimal clinical response. There is a growing body of evidence shows the necessity for shifting to a multitarget approach in the field of drug discovery [1]. Traditional medicines which have holistic viewpoints in maintaining the overall balance of the body usually put forward such approach in their drug formulations as suggested in systems biology [2,3]. It may be the reason of recent more interest of pharmaceutical companies for research in traditional medicines [4]. Nonetheless, it has its own troubles; multicomponent formulations, possible toxicities, and lack of our knowledge regarding their mechanism of action are some of the obstacles. Understanding the concept of ameliorations –which means modulation of the effects and/or counteracting the side effects of ingredients of a compound formulation by one of its constituents– mentioned as Musleh in Traditional Persian Medicine and jun-chen-zuo-shi in Traditional Chinese Medicine, could pave the way for further researches in this field. Keywords: Drug discovery, Systems biology, Traditional medicine, Amelioration
C. V. Nnamani
Ebonyi State University, Nigeria
Title: Bark extractism the key threat to medicinal plants sustainable conservation: their taxonomic index and nigerian perspective
Biography:
Will be updated soon!!
Abstract:
Traditional medicine is an important source of primary healthcare system in most rural communities in Nigeria. This high reliance on traditional medicine can be attributed to accessibility, local availability, affordability; existence of local knowledge and expertise and synergy with their cultural belief. However, the indiscriminate and non-systematic approach of harvesting by debarking is impacting on the availability of these species. Taxonomic index of these species and the implications of bark removal in five communities in Ebonyi State, Nigeria was carried out through oral interviews, field observation and focal group discussions with traditional healer and drivers of medicinal plants who are knowledgeable in that field were assessed. Results highlighted those flora families and taxa mostly affected to include Apocynaceae, Anacardiaceae, Longanaiceae Meliaceae, Rubiaceae Moringaceae, Bignoniaceae and Fabiaceae with its highest impact on Alstonia boonei, Anthocleista djarlonensis, Azadichrata indica, Khaya senealensis, Morinda lucida, Moringa oleifera, Nauclea latifolia and Anacarduim occindentale. Six out of these taxa are now rare, threatened or endangered with no policy program on the germsplam domestication and conservation. The medicinal uses of these medicinal plants and implication of debarking on sustainable conservation are discussed. Keywords: Debarking, herbals, exploitation, sustainability, Nigeria
Shujaulmulk Khan
Quaid-i-Azam University, Pakistan
Title: Traditional uses of plants among various casts of district tor ghar
Biography:
Shujaul Mulk khan is Assistant Professor of Plant Sciences, Quaid-i-Azam University Islamabad Pakistan. He did his PhD from University of Leicester, UK followed by a Post doc from the same University. He has distinctions in his academics. His fields of specializations are Plant Ecology, Biodiversity Conservation, Vegetation Modelling, Ecosystem Services, Ethnobiology and Syntaxonomy. He has published numbers of books and journal articles in reputed journals. He has supervised numbers of students at PhD, MPhil and MSc level. He is member of editorial team and reviewer of numbers of journals and member of scientific journal.
Abstract:
Interaction between plants and people is much stronger in remote tribal societies all over the world. District Tor Ghar is one of such remote and rugged mountainous region of the extreme western Himalays that has historically long established tribal culture. The district is occupied by 5 main tribes namely Basikhel, Nusratkhel, Akazai, Hassanzai and Medakhel. A total of 43 villages from all tribal belts were randomly selected by using random table number method. Every Third house was selected on willingness basis. Local wisdom of 732 informants of all age groups including males and females was explored first time by standard ethnobiological protocol. Information about 295 ethno species utilized by five tribes for 33 cultural use categories was gathered via semi structured interviews, group discussions, EPA and extensive field visits. Cultural uses among different tribes were categorized by using modern software computer package PCORD version 5.1 for TWCA. All 33 cultural use categories were grouped in to 11 sub clusters among five tribes. These 11 sub clusters were further organized in to two main clusters. One main cluster comprised of Basikhel and Nusrat khel tribes sharing maximum use categories whereas the second main cluster represented highest number of common use categories among Akazai, Hassanzai and Medakhel tribes. Handling of cultural data through modern software packages is first ever attempt in the region.