Jaspreet Kaur is a Pharmacist from India who is pursuing her masters in Pharmacology from Chandigarh College of Pharmacy,CGC (Punjab Technical University), India. She is a researchscholar and doing her research work on Alzheimer's disease. Jaspreet Kaur did her Bachelor in Pharmacy from Punjabi University Patiala, India. Now she's in second year of her masters in Pharmacology and is working on root extract of Coleus forskohlli for the treatment of Alzheimer's type of dementia. After completing her research work, she'll be writing thesis for the research done. Jaspreet Kaur has attended a number of conferences in India related to her research work and now is looking forward to attend conference and to present poster of research done in Herbals summit-2015.
The present study was designed to investigate the potential of Coleus forskohlii plant extract- ‘forskolin’ in experimental dementia in wistar rats. Dementia was induced by the administration of high fat diet (HFD) for 90 days. The effects on learning and memory were assessed using Morris Water Maze (MWM) test. A battery of biochemical tests such as brain thiobarbituric acid reactive species (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), brain acetylcholinesterase (AChE) activity, myeloperoxidase (MPO) activity and total serum cholesterol levels were measured. Administration of high fat diet significantly impaired the learning and memory and also deleteriously affected the biochemical parameters. Administration of forskolin (20 mg/kg, p.o.) for 14 days significantly attenuated high fat diet induced memory deficits and the biochemical alterations. Combined administration of forskolin and Pregnane X receptor (PXR) antagonist, Ketoconazole (25 mg/kg, p.o.) significantly reduced the beneficial effects of forskolin in HFD treated rats. This study demonstrates that improvement of memory by forskolin administration may occur as an outcome of its antioxidative, anticholinergic, anti-inflammatory, hypolipidemic and amyloid lowering potential. The study also proposes the possible involvement of Pregnane X receptors in the pathophysiology of experimental dementia.
Woo Seung Yang study for the Mastaer’s course in Department of Medical Biomaterials Engineering, College of Biomedical science, Kangwon National University. His major is pharmacognosy.
Clematis mandshurica (C. mandshurica) is a traditional crude drug for treatment of urethritis, carbuncles and carcinoma. The objective of this study was to confirm the cognitive enhancing effect C. mandshurica using two behavioral tests, Morris water maze test and passive avoidance test. 50, 100 and 200 mg/kg of C. mandshurica extract were administered to mice. We also investigated acetylcholinesterase (AChE) activity and brain-derived neurotropic factor (BDNF) expression and cAMP response element-binding protein (CREB) phosphorylation in scopolamine-induced memory deficit on mice to determine possible mechanism. The results revealed that C. mandshurica attenuated learning and memory impairment by scopolamine. C. mandshurica also inhibited acetylcholinesterase level in hippocampus of scopolamine-injected mice. Moreover, C. mandshurica increased BDNF and p-CREB expression in hippocampus. These results indicated that C. mandshurica improved memory impairment through AChE inhibition and BDNF and p-CREB expression and suggesting that C. mandshurica may be a useful therapeutic agent for the prevention or treatment of Alzheimer’s disease.