3^rd Global Summit on Herbals and Traditional Medicine October 18-20, 2017 Osaka, Japan

Biography:

Younghee Yun has completed her PhD from college of Traditional Korean Medicine, Kyung Hee University, Seoul, Korea. From 2007 to June, 2017, she had worked as a clinical assistant professor of allergic/derma clinic of the Kyunghee University Korean medicine hospital at gangdong, conducted clinical studies in allergic skin diseases, and has published more than 12 papers. She is the CEO of CY Pharmaceutical Co., Ltd., a herbal medicine manufacturing and development company. Her main interest is atopic dermatitis, allergic skin disease and pharmacological action of herbal medicine.

Abstract:

Atopic dermatitis (AD) is a common pruritic inflammatory skin disease. In its chronic stage, hyperpigmentation, excoriation, lichenification, and dryness are the main symptoms. Jaungo comprises two herbs, Lithospermi radix and Angelica gigantis radix, and three carrier oils, and is an approved herbal ointment for xerosis in Korea. In past preclinical studies, we demonstrated that Jaungo had anti-inflammatory and anti-allergic activity. We conducted a randomised, double blind, placebo-controlled, single-centre trial with three parallel arms. Trial group 1 applies Jaungo twice a day, while trial group 2 applies Jaungo and the placebo once a day, separately, and the placebo group applies the placebo twice a day, for a total of 3 weeks each. Participants evaluated for eczema based on the Eczema Area and Severity score, the SCORing of Atopic Dermatitis Score, the Dermatology Life Quality score, transepidermal water loss, total IgE level, eosinophil count, and IL-17, IL-22, and IFN-γ levels. The outcomes to evaluate the safety included Draize score and blood test. In total, 28 patients (82.4%) completed the study. Significant decline of EASI scores in trial group 2 and placebo group was observed (p<0.05). There was significant decline of SCORAD scores in trial group 1 and placebo group (p<0.05). However, Patients in all groups showed decreased TEWL and DLQI scores with no significant difference. No clinically relevant changes in laboratory values were observed except IL-17. There was significant decline of IL-17 in all groups (p<0.05). Inter-group analysis showed no significant difference. No serious adverse event was observed.

Biography:

Jurairat Boonruab earned her Ph.D. from Chulalongkorn University, Thailand in 2015. She is currently Deputy Head of the Academic Affairs Department and a lecturer at the Faculty of Medicine of Thammasat University, Thailand. Her areas of specialization include applied Thai traditional medicine, alternative medicine, and public health science. She has published Thai massage and Heber medicine.

Abstract:

Myofascial pain syndrome (MPS) is one of the most prevalent illnesses among those in the working age group caused by poor ergonomics, especially remaining in a sitting posture for an extended period of time. One alternative treatment for MPS is the application of a hot herbal compress, which helps to improve the quality of life of patients and reduce the undesirable side effects of pain relief medication. A controlled trial was conducted in which 90 participants were randomized into the hot herbal compress group (n=30), the hot compress group (n=30), and the topical diclofenac group (n=30). The first two groups received a 20-minute hot herbal compress and hot compress treatment not exceeding the temperature of 40 °C once a week for two weeks, whereas the last was administered 2 mg of a topical diclofenac gel three times a day for two weeks. Before and after the treatment, their level of pain intensity and quality of life was assessed using a visual analog scale (VAS) and the 36-Item Short Form Health Survey (SF-36), respectively. Additionally, their cervical range of motion (CROM) and pressure pain threshold (PPT) were also evaluated. It was found that all the three groups experienced a statistically significant decrease in the level of pain intensity (p<0.05), a statistically significant increase in CROM (p<0.05), a statistically significant increase in PPT (p<0.05), and a statistically significant improvement in the quality of life (p<0.05). However, for the last two assessment criteria, the results for the hot herbal compress group and the hot compress group were not only relatively equal but also better than those for the topical diclofenac group.

Biography:

Capt. Dr. Chaiwat Thepsena,RTN has completed MD at the age of 24 years from Faculty of Medicine, Chulalongkorn University, furthered his studies acupuncture and moxibustion from Shanghai, M.S.c.(medical epidemiology) and also studied about neural therapy.  He practices for CAM (Complementary and Alternative Medicine) nineteen years at Somdech Phra Pinklao Hospital, Naval Medical Deparment.

Abstract:

Qing Kai Ling is known for neuro protective effect by relieving the damage of vascular endothelial cell as well as inhibiting the process of inflammation and also increases expression of endothelial nitric oxide syntheses. Clear body heat and detoxification is another benefit effect from Qing Kai Ling. During 10 years of usage this injection among 25,000 patients of coronary heart decease, cerebrovascular decease, chronic renal failure, respiratory tract infection, and cancer patients. The results appear so fantastic. Most of the patients become better after being treated. Coronary Artery Stenosis and Cerebral Artery thrombosis patients have evaluated by CT scan which show disappear of occlusion. Only four patients become worse with hypotension but recovery after using moxibustion.

Biography:

Kusuma Sriyakul   completed her PhD (Thai traditional and Alternative Medicine) in 2012 at  Chulalongkorn University Thailand. She is the lecturer at Chulabhorn International College of Medicine, Thammasat University Thailand. She has published several papers about herbal medicine in dysmenorrheal, Thai traditional formula.

Abstract:

Yanang Daeng (Bauhinia strychnifolia Craib.) was used for a treatment of poisoning, elimination of pesticides, an effect of poisonous mushrooms, poisoning, breast  milk stimulation in women after delivery and reduce fatigue, the study aimed to gather the knowledge and experience from the folk healers about the usage of Yanang Daeng. This study was conducted using in-depth interview and group discussions from folk healers in four sectors throughout Thailand. The results showed those 59 folk healers from 4 sectors which consisted of 67.80% male and 32.20% female. Furthermore, the age of the participants was studied and the results showed that they aged ranged among 61-80, 41-60, 20-40 and more than 81 years old which respectively accounted for 49.15%, 30.51%, 13.56% and 6.78%. For the treatment of patients who receive the toxins, some folk healers will grind the root with water or water from washing rice, then the patient will be immediately received a single dose portion of 2 tablespoons, but the others will boil the leave and stems and give the patient a single dose portion range from ½ to 1 glass. In emergency case, they will use 10 fresh leaves, then squeeze with water or water from washing rice, and immediately give to patient as a potion. Moreover, the folk healers recommended to the villager that they should use leaves rather than using vine or root to prevent the extinction and also suggested them to plant for convenient use. Yanang Daeng is potent in solving the urgent poisoning problem in the community before receiving further treatment.

Biography:

Dr Ray Cooper was born in the UK, received his Ph.D. in organic chemistry and after 15 years in R&D in the pharmaceutical industry, he moved to the dietary supplements industry. He developed new Chinese botanicals as supplements including Cholestin, Cordymax and Te-Green.

Currently Ray is visiting professor and lecturer at the HK Polytechnic University and co-founder of PhytoScience LLC, a consulting company creating innovative botanical solutions and products.

He is the recipient of the 2014 American. Society Pharmacognosy Tyler Prize for his life time contributions to Botanical Research. He is also a Fellow of the Royal Chemical Society, UK.

Ray has recently published three books:  Natural Products Chemistry: Sources, Separations and Structures (CRC PRESS) and Botanical Miracles, Plants that Changed the World, and Chinese and Botanical Medicines. He has edited 5 books, most recently, Botanical Medicine: from Bench to Bedside and published over 100 peer reviewed scientific articles.

Abstract:

With the gluten-free food market worth almost $3.6bn in 2016, there is every reason for renewed interest in ancient grains. This resurgent interest is expressed in re-discovering ancient varieties as functional foods. In particular, people affected by celiac disease have to avoid all gluten in their diet and several ancient grains may offer an important alternative.

Ancient grains include chia, a forgotten food of the ancient Aztecs; quinoa which originated in the Andean region of Ecuador, Bolivia, Colombia and Peru; triticum (wheat), in the form of einkorn, known today as farro in Italy, as a type of awned wheat and one of the first crops domesticated in the Near East. Other grains, acknowledged as gluten-free ancient grains are amaranth, eaten in Mexico since the time of the Aztecs; quinoa, sorghum, millet; and teff, the main ingredient in the stable fermented flatbread, injera, in Ethiopia. A description of modern wheat is presented together with each one of the above mentioned grains-

Biography:

Wilfred Mabusela completed his PhD at the University of Cape Town, South Africa, and this was followed by two years of postdoctoral studies at the same institution, which extended his doctoral work on structural studies of plant polysaccharides. He subsequently took up a lecturing position at the University of the Western Cape where he is currently an associate professor. He has published more than 30 papers in reputable journals, and has been a visiting scientist at institutions in Europe and North America.

Abstract:

Traditional medicine is a cultural practice with a long history in Africa, and in South Africa it involves the use of approximately 3000 plants, out of a national biodiversity represented by about 30 000 higher plant species. For most of these, there is very little information about their phytochemical constituents, given that the therapeutic value of these plans is known to reside in their phytochemical composition. Furthermore, for most of these plants, some of which are on the open market, there are still no strict quality control reference data, which verifies the phytochemical profile of a particular plant sample. Hence the purpose of this study is broaden the knowledge on the phytochemical composition of medicinal plants, information which is expected to facilitate an understanding of their mode of action, in terms of therapy and toxicity. Methodology: Some medicinal plant species from South Africa and other African countries were collected.  Dried material samples were subjected to extraction using water as well as a variety of organic solvents followed by chromatographic fractionation of the extracts obtained. Isolated compounds were examined for their chemical structural features with the aid of nuclear magnetic resonance and mass spectroscopy. Some of the crude extracts and purified compounds were also studied for biological activity such as antioxidant activity, cytotoxicity (using the brine shrimp lethality bioassay), for antimicrobial activity against gram-negative and gram positive bacteria as well as fungal species, and enzyme inhibition properties. Findings:  Spectroscopic studies led to the identification of compounds belonging to the following classes: flavonoids and, terpenoid- and flavonoid- glycosides. Some extracts and isolated compounds displayed a broad spectrum of biological activities.

Biography:

Dr Tshikalange is a senior Lecturer in the Department of Plant and Soil Sciences of the University of Pretoria, South Africa. His research focus areas include ethno-botanical medicinal plants used traditionally in the treatment of sexually transmitted diseases, oral pathogens and antimicrobial activities. He has published articles in peer reviewed national and international journals, such as the South African Journal of Botany and Journal of Ethnopharmacology and has been serving as an editorial board member of BMC Complementary and Alternative Medicine. He co-authored chapters in the book Medicinal plant research in Africa: pharmacology and chemistry. Several postgraduate students have completed their studies under his supervision.

Abstract:

Sexually transmitted diseases have a major impact on sexual and reproductive health worldwide. Each year, the World Health Organization estimates 448 million new cases of curable STD’s are diagnosed. Ethanol extracts of twelve South African medicinal plants used in the treatment of STD’s and 3 flavonoids were investigated for their antimicrobial activity against Candida albicans, Gardnerella vaginalis, Neisseria gonorrhoeae and Oligella ureolytica. The anti-inflammatory activities of the extracts and compounds were determined by measuring the inhibitory effect of the extracts and compounds on the pro-inflammatory enzyme lipoxygenase. The extracts and compounds were also investigated for their anti-HIV activities against recombinant HIV-1 enzyme using non-radioactive HIV-RT colorimetric assay. Acacia karroo and Rhoicissus tridentata extracts showed good antimicrobial activity with MIC values ranging between 0.4 and 3.1 mg/ml. Extracts of Jasminum fluminense, Solanum tomentosum and flavonoids 2 and 3 had good anti-inflammatory activity with IC₅₀ less than the positive control, quercetin (IC₅₀ = 48.86 ug/ml). A. karroo and flavonoid 3 exhibited moderate HIV-1 RT inhibition activity of 66.8 and 63.7 % respectively. R. tridentata and Terminalia sericea had the best RT inhibition activity (75.7 and 100 %) compared to that of the positive control doxorubicin (96.5%) at 100 ug/ml concentration. The emergence of drug resistance in STD related microorganisms and potential side effects demand the discovery of newer drugs. The exploration of newer anti-microbial substances from natural sources may serve as promising alternatives. The observed activities may lead to new multi-target drugs against sexually transmitted diseases.

Biography:

Dr. Hsieh has complete the Chinese Medicine Doctor scholarship from China Medical University in Taiwan. He is serving as a Chief Resident Doctor of Chinese Medicine in Department of Chinese Medicine, Taipei Tzu Chi Hospital. He has intensively study in ShangHanLun and the Pulse Diagnosis of Traditional Chinese Medicine.

Abstract:

Introduction

Generally, western medicine treat patients with insomnia disorder in inhibiting or releasing way. But in the concept of Yin-Yang in Traditional Chinese Medicine(TCM), it’s not always effective to the Yang Deficiency patients, especially the Heart Yang Deficiency ones. We consider that being frightened could leads to Heart Yang Deficiency and Spirit-Restless Pattern in TCM.

Material and Methods

This case is a 64-year-old woman, suffered from domestic violence intermittently in 2015 and then divorced. After that, insomnia disorder, palpitation, empty feeling in chest, panic and anxiety was noted. Also, she dreamed about being hit accompanied with somniloquy and waving arms every night for about a year. There’s also weak pulse in cun position of both wrist pulse. Those symptoms and pulse findings are the same features as the Heart Yang Deficiency. Therefore, we treated her by warming Heart Yang and settling the Spirit formula (extract powder of Guizhi-Gancao-Longgu-Muli Decoction桂枝甘草龍骨牡蠣湯) 2.6gm four times a day since 2017/1/5.

Result

After the first week receiving the formula, there’s still dreamful sleep, but the palpitation partially relieved. After the second week, dream alleviated with only somniloquy left. Palpitation, empty feeling in chest and panic also relieved obviously. There was no significant side effect during or after the treatment.

Conclusion

We suggest that warm Heart Yang and settling the Spirit formula (Guizhi-Gancao-Longgu-Muli Decoction桂枝甘草龍骨牡蠣湯) is an effective and safe treatment for the Heart Yang Deficiency patients.

Biography:

Dr. Mohammad Zashim Uddin obtained His B.Sc. (Hons.) and M. Sc. (Thesis) Degrees in Botany from the University of Dhaka. Later He awarded with Ph. D. degree at the age of 32 years from the same University. Dr. Zashim trained from USA on tropical biodiversity conservation and research proposal development.  His current position is Professor in the Department of Botany, University of Dhaka and supervised 29 MS research students and presently guiding one Ph D student and three MS students. By this time, He published 63 research articles/books/book parts in different national and international scientific journals

Abstract:

The present article focuses the consensus of local people of Brahmanbaria district in the use of ethnomedicinal plants to treat different ailments in their daily life. Data on medicinal use of plants were collected in between June 2015 to June 2016 from 459 local people using mainly modern ethnobotany survey techniques. A total of 208 medicinal plants under 83 families were recorded. Such plants are used to treat 73 ailments through 407 formularies. The most commonly used medicinal plants are Centella asiatica, Litsea glutinosa, Coccinea cordifolia, Azadirachta indica, Cynodon dactylon, Ocimum sanctum, and Leucus lavandulifolia. Among the ailments categories high informant consensus factor (Fic) was found in case of diarrhoea and dysentery followed by kidney disorder, respiratory tract disorder, gynecological, fever and pain, dermatological, helminthiasis, skeletomuscular pain, diabetes and liver disorder, gastrointestinal, cardiovascular, jaundice, mental, impotence, teeth ache and ophthalmological. Most cited species for the treatment of such ailment categories are Litsea glutinosa, Holarrhena antidysenterica, Kalanchoe pinnata, Ocimum sanctum, Abroma augusta, Alternanthera sessilis, Azadirachta indica, Ananas sativus, Achyranthes aspera, Coccinia cordifolia, Andrographis paniculata, Hyptis sauveolens, Terminalia arjuna, Eclipta alba, Cajanas cajan, Asparagus racemosus, Kalanchoe serrata, and Commelina benghalensis. Among medicinal plants, Centella asiatica, Adhatoda vasica, Clerodendrum viscosum, Clitoria ternatea, Tinospora crispa, Dalbergia sissoo, Ficus benghalensis, Ficus hispida, Holarrhena antidysenterica,  Paederiea foetida,  Scoparia dulcis and Thevetia peruviana were showed 100% Fidelity level (Fl) values. Plant species with high citation, Fic and Fl values can be subjected to further ethnopharmacology studies to find active compounds for the new drug candidates

Biography:

Christopher T. Arick, DC, MS is currently the Assistant Dean and Chief Acacdemic Officer of Chiropractic Medicine at the National University of Health Sciences. He has completed his Doctor of Chiropractic degree at National University of Health Sciences in 2005 and has earned a master’s degree in advanced clinical practice. Dr Arick has taught for the university for since 2012. He is currently pursuing a PhD in Higher Education Administration from the University of South Florida where his research topic is integrative medicine education.

Abstract:

The purpose of this case report was to describe the examination and management of a patient with chronic fatigue. A 34-year-old woman presented to a chiropractic clinic with complaints of fatigue and inability to lose weight for 2 years. When tested, she was found to have high serum thyroglobulin antibodies, low serum vitamin D3, low saliva dehydroepiandrosterone-sulfate, and low saliva total and diurnal cortisol. The patient was placed on an anti-inflammatory ancestral diet and given recommendations to decrease the aerobic intensity of her exercise routine. On the basis of the result of conventional and functional laboratory tests, she was prescribed a treatment plan of targeted supplementation. After 12 weeks of application of dietary, lifestyle, and supplementation recommendations, the patient reported experiencing increased energy and weight loss of 15 pounds. Her thyroglobulin antibodies returned within reference range, salivary cortisol increased and closely followed the proper circadian rhythm, and dehydroepiandrosterone-sulfate increased. This report describes improvement in a patient with chronic fatigue with the use of nonpharmaceutical polytherapy involving dietary changes, lifestyle modification, and supplementation.

Biography:

Karin Kraft is qualified in internal medicine and naturopathy, and holds the chair of naturopathy at the University Medicine of Rostock, Germany since 2002. She has published more than 140 papers in reputed journals and is president of the German Society on Phytotherapy since 2010.

Abstract:

In Europe, herbal medicinal drugs (HMPs), and food, including food supplements, have different legal definitions (Directive 2001/83/EC and Regulation 1924/2006, respectively). They therefore must be clearly separated. HMPs have pharmacological effects and are used for therapy, relief, prevention or diagnosis of diseases. They are subdivided into HMPs with the status well-established use (proven efficacy by at least one sufficient clinical study, proven quality and tolerability, and indications for mainly mild diseases), and HMPs with the status traditional use (proven quality and tolerability, and indications for minor health problems). On the contrary, foods and food supplements have physiological effects and are primarily used for nutrition or health-related effects by healthy consumers. There is no commitment to control for their quality and tolerability, and they are promoted by a health claim. In the EU, food supplements produced from plants and their preparations (“botanicals”) until now very often have unapproved health claims reminding of the indication of HMPs with traditional use status. However, consumers have to be informed correctly on the nutrition and health value of plants and their preparations contained in food and food supplements in order to be able to choose the appropriate product for their needs. Hence, all health claims should be based on relevant health-related effects that have been proven by adequate scientific evaluation.

Biography:

Poet, Psychiatrist and Psychotherapist, Bihabwa worked as a psychiatrist for four years in the eastern Democratic Republic of Congo. Among other things, he treated women who had been raped and their children, from rape. He was the coordinating doctor of the National Program of Mental Health in the province of South Kivu. He worked at the Fann hospital in Dakar for three years before going to France at the EPSM des Flandres.Psychiatrist, he specialized in Transcultural approach at the University Paris Descartes, in the program coordinated by Professor Marie-Rose Moro.His research explores the problem posed by traumatic events on social and societal dynamics. He works on the trauma and resilience of children from rape in a patrilineal patriarchal society. He is particularly interested in topics related to the transmission of trauma and Transgenerational trauma.In the treatment, he works on the complementary approach, which combines traditional and modern approaches.

Abstract:

Introduction

To have studied, worked and earned his salary constituted a transgression against the will of the deceased father. To be purified, a special course was necessary: healers-exorcists-hospital.
The individual experience of illness exhumed, in B, conflicts between transmissions, filiations and affiliations.
It is the relation to knowledge in a universe where it draws from two sources, made heterogeneous.

Results

M'B grew up in the royal court, emblematic symbol of the pure tradition. Graduated as nurse, he was hired by the Congolese organization of emergency management, Croix-Rouge du Congo. As head of an aid worker team, M Bami is led to deal with disasters, especially those produced by the exactions of armed groups given the current state of the security context in eastern DRC.

In the middle of a mission, to intervene in a slaughter in which was killed thirty-eight people, a psychic trauma was triggered in him.

Alongside the literary descriptions ―learned in school and used every day for his patients― the reading of his own suffering is traditional first. M Bami has managed to subtly carry his illness within an area where mix Western type treatment and traditional type. This disease was, in addition, an opportunity for rereading family ties, relationships between his ―very demanding― work and his father’s will. The king's witch doctor, the same who treated his father, provided the key, by his ritual to soothe family disputes. He also updated the meaning of symbols in order to establish individual and collective narrative identity, so that M B's work is no longer in conflict with his deceased father's will.

Conclusion

The value of this case lies in the reflection on modernity in the health system to provide mediation between two intentionally made heterogeneous universes: the theories of some against realities of living of others. Caregiver training, while remaining scientist would benefit from being closer to cultural practices to finally aspire to its note of nobility: become more Humans.

Biography:

Daniela M. A. F. Navarro has completed his PhD at the age of 27 years from University of São Paulo (USP) and postdoctoral studies from Federal University of Alagoas (Brazil)/IACR-Rothamsted, U.K.. She has published more than 60 papers in reputed journals and has been serving as referee of reputed journals.

Abstract:

Aedes aegypti is vector of Dengue and Yellow Fevers, a mosquito of public health importance. It is the most broadly disseminated urban species of mosquito in the world. Larval insecticide is one of the alternatives to control the mosquito dissemination. Temephos and Bacillus turinghiensis subsp. israelensis (Bti) are the larvicidal most used in the world to combat A. aegypti mosquito. In face of larvae resistance to Temephos and the high cost of Bti production in large scale, research programs on insecticides often focus on alternative compounds and natural products as rich sources of larvicides. Repelletn and oviposition deterrent are used to reduce the contact between infected mosquito and urban population. In this work we describe significant larvicidal, repellent and oviposition deterrent activities research of essential oils against A. aegypti. Some larvicidal acitivity of plants and seweed will described.

Biography:

Xin Zhou has completed her PhD at the age of 42 years from West China school of pharmacy, sichuan university. She is the director of Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, a premier herbal medicine quality control service organization. She has published more than 150 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract:

A sensitive, reliable and accurate HPLC-MS-MS method was developed and validated for the quantification of Gallic Acid (GA) and Protocatechuic Acid (PCA) in rat plasma, tissue and excretion. A single-step protein precipitation by acidic acetonitrile was used to prepare samples. GA, PCA and bergenin (internal standard, IS) were separated by using a C₁₈ column and a mobile phase consisted of acetonitrile and water containing 0.1% formic acid running at a flow rate of 0.2 ml/min for 10 min. Detection and quantification were performed using a mass spectrometer by the multiple-reaction monitoring (MRM) in positive electrospray ionization mode. The optimized mass transition ion pairs (m/z) for quantitation were [M+H] 169.181 →125.268 (GA)、152.918 → 109.244 (PCA) and 326.922 → 192.167 (IS) , respectively. After oral administration of 0.36, 1.08 and 2.16 g·kg^-1 of Polygonum capitatum extract, respective values of pharmacokinetic parameters for GA and PCA were: t_1/2 1128.52/42.81、93.72/90.15and 114.70/49.80min; C_max 245.98/11.90, 477.20/24.66, and 805.76/31.04 ng·ml^-1. Linear pharmacokinetics was established based on high correlation coefficients (γ > 0.90) of pharmacokinetic parameters. The results of tissue distribution showed that GA mainly distributed in kidney, lung, and liver, while PCA mainly distributed in kidnry and lung. Less than 23.08% and 19.39% prototype of GA and PCA , respectively, were excreted from urine and feces path indicating that GA and PCA are extensively metabolized in rat.

Biography:

Dr. Mohammad Kamil a Chartered Chemist and  Fellow of Royal Society of Chemistry London   is Head TCAM Research Section, Zayed Complex for Herbal Research & Trad.Medicine, Regulation Division ,Health Authority –Abu Dhabi,UAE  .Recipient of Common Wealth Award-London; Convention Award of Chemical Society-India; Academic Exchange Fellowship from Association of Common Wealth Universities -London; and Global award on Unani Medicine and various other prestigious honors &  awards. Worked as in charge of Drug lab.MoH India, Professor at Jamia Hamdard University, Produced 6 Ph.Ds and 14 M.Phil. Students . More than 325 papers and abstracts in reputed journals and international conferences are at credit; chaired a no. of scientific sessions and presented invited talks as plenary and invited speaker at various International conferences / symposia.  Associated with publication of many books; Author of a book and five chapters in different books; Research work cited widely in books e.g. Advance in research, Chapman and Hall, London.

Abstract:

The challenges are innumerable and enormous, making the global herbal/botanical market unsafe. The talk seeks to enlighten physicians, pharmacists, consumers and stakeholders in botanical medicine on the need to establish quality parameters for collection, handling, processing, manufacturing and production of safe botanicals as well as employ such parameters in ensuring the safety of the global botanical market which is directly linked to the safety of public health.

In the recent years with ever growing commercialization in the field of herbal medicines, there has been an instant demand for quality control of the drugs used in this system. The studies on the identity, purity and quality of the genuine drug will enhance information in checking the adulteration. A set of standards would not doubt be detterent on substitution and adulteration and also an aid for ‘Drug law Enforcement’.

In the present paper an attempt has been made for a sequential  study of the Quality Control of Herbal Medicinal Products ( HMP ) starting from Selection of Medicinal Plants ;Good Agricultural Practices (GAP ) Cultivation ;Good Field Collection Practices(GFCP) ; Organized and Unorganized Drugs ;Source and Period of Collection; Identification; Storage  ; Chemical Standardisation ; Assay ; Good Manufacturing Practices (GMP) and Pharmacological studies to Clinical Approach , with special reference to maintain Standardisation at each and every stage.Adulteration of  unlabled ingredients/hidden ingrediets will be discussed with practical laboratory  experience.

Biography:

Will be updated soon

Abstract:

Microtubule-associated protein light chain 3-II (LC3-II), and Sequestosome-1 (SQSTM1) are proteins that can be used as markers for autophagic pathway. Bcl-2 is a protein that is reported to be inversely correlated with apoptosis. We aimed to investigate the effects of curcumin on liver inflammation and fibrosis up to the first dysplastic stage of Hepatocellular carcinoma (HCC) induced by Thioacetamide (TAA) in rats and clarified the effects of curcumin on LC3-II, SQSTM1, and Bcl-2.

Male Sprague-Dawley rats were randomized into 4 groups: Control group and 3 groups received TAA 200 mg/kg i.p. twice weekly for 18 weeks: TAA group, Curcumin low-dose group, Curcumin high-dose group. Oxidative stress markers as hepatic malondialdehyde (MDA) concentration and superoxide dismutase (SOD) activity were measured by colorimetric methods. Hepatic SQSTM1 concentration was measured by ELISA, and gene expression levels of Bcl-2, and LC3-II was measured by RT-PCR. We also investigated the In vitro effect of curcumin on HepG2 cells viability through MTT assay, and the involvement of autophagy in this effect.

Curcumin increased the survival percent in rats, decreased α-fetoprotein (AFP) concentration, and serum aspartate aminotransferase (AST) activity, and increased serum albumin concentration. Curcumin also caused a significant reduction in oxidative stress in liver, inhibited apoptosis, and induced autophagy. In vitro, It was found that curcumin decreased HepG2 cells viability and the concentration of SQSTM1.

In conclusion, curcumin leads to protection against TAA induced HCC through activating autophagic pathway and inhibiting apoptosis. Also, The antioxidant activity of curcumin almost prevents liver fibrosis.

Biography:

Dasril BASIR  has completed his Chemistry Bachelor at  Andalas University  in 1984 and Master in Organic Chemistry at The Institute of Technology Bandung, Indonesia  in 1986.  One year research  of Intership of Organic Synthesis at School of Chemistry, UNSW, Sydney, Australia in 1989. The Six Months Joint Research on RGD Peptidemimetics at Department of  Pharmaceutical Chemisry, The University of Kansas, Lawrence, USA in 1995 and Six Months Researc visit of Natural Products Chemistry and  Biologycal Activity  at Institut Fur Pharmazeutische Biologie,  Heinrich Heine  Universitat , Dusseldorf,  Germany in 2002. He has three sccopus published articles dealing with phytochemistry works on Fragraea fragrans fruits  and two DOAJ published articles.

Abstract:

Fragraea fragrans fruits are locally named buah tembesu, belongs to Loganiaceae family. Those can be harvested two time a year, in May and in November. The major secondary methabolites of the fruits are ursolic acid and its isomer oleanolic acids (3.1% accounted from the dried ones). In order to develop these fruits become topical herbal cosmetic products for skincare. The bioactive compounds of the fruits have been mapped to consider their side effects as well as their  efficacy. Eleven compounds have been successfully identified with LCMS/MS from the filtrates of the methanol extracts of the fruits after the solid crystals of ursolic acid and its isomer oleanolic acid  have completely precipitated^[1,2], and their chemical structures were confirmed by comparing their molecular ion peaks to relevant compounds in some of references respectively; including the fragment ion peaks patterns.  As a result, those compounds were clasified into phenyl propanoic, pentacylic triterpene acids, flavones, phenyl propanoic, and tanin trimer groups.

Biography:

Susy Tjahjani is a PhD.and works as a lecturer and a chairman of Tropical Disease Research, Medical Research Centre in Faculty of Medicine, Maranatha Christian University.

Abstract:

In order to overcome malarial resistance tendency against ACT (artemisinin based combination therapy), several galenic preparations of Garcinia mangostana L rind have been studied and they have antimalarial activity in vitro. One of the major xanthones in this rind may contribute to this activity. Curcumin as one of the major compound of Curcuma domestica, is also potentially to have antimalarial activity. The aim of this study was to evaluate the antimalarial activity of this xanthone, curcumin, and one derivate of artemisinins and also to evaluate their mechanism of action. Interaction between them each other as antimalarial in vitro was also studied. Antimalarial activity was studied in in vitro 3D7 Plasmodium falciparum cultivation incubated with these compounds to look for the IC50 and ∑FIC50 of them. The mechanism of action of these compounds was observed electron microscopically. The result of this promising study would be reported.  

Biography:

Dr. V. Veena is currently working as Assistant Professor at School of Chemical and Biological Sciences, REVA University, Bangalore, India. Dr. Veena did her doctoral studies from Pondicherry University, India in 2016 and has 8 years of Research experiences and one year of teaching experience for post graduate and graduate students. Her area of Research includes small molecules of diverse origin for cancer therapy and nanophotosensitisers for photodynamic therapy. She is recipient of junior and senior research fellow from Council for Scientific and Industrial Research (CSIR) and University Grant Commission (UGC), Government of India. She was also awarded Research Project Assistant in UGC-SAP (special assistant program) by Department of Biotechnology, Pondicherry University, India. Her research contributions was published peer reviewed international journals and she is reviewer of some journals.

Abstract:

Statement of the Problem: Several herbal and ayurvedic preparations are currently used to treat the cancer patients. Although, several herbs used in such treatment contains pharmacologically important molecules but they are yet to be identified and their mode of action is not studied in detail. Cancer is defined as a wound that never heals due to its complicated cellular organizations. Thus, the main objective of present investigation was to identify the herbal leads that target the inflammatory tumor environment through modern approaches.

The purpose of this study: India is the major country that is rich in the biodiverse compounds to treat disorders through herbal and ayurvedic approaches. Several natural lead molecules are being reported and continuously being investigated globally. The good examples are being curcumin and taxol derivatives of natural origin that is effective against cancer and inflammatory disorders. Identification of small molecule drugs from herbs by increasing the selectivity towards tumor is the prime importance of the study. In this context, we have investigated several diverse herbal lead molecules that aimed to increase the selectivity and inflammatory aspects of heterogenic cancer components.

Methodology and Theoretical Orientation: The major photochemical components of herbs used in treatment of various disorders was screened to identify an active components based on preliminary studies. Further, through virtual screening, the compounds were identified against cancer specific targets by computational approaches. The results were validation by in vitro interaction studies and cell-based approaches followed by in vivo toxicity studies.

Findings:The lead molecules were obtained that can be used for in vivo studies for development of anticancer drugs. The findings also enriched the knowledge regarding mechanistic approach of ayurvedic drugs being used.

Conclusion and Significance: The active herbal constituents that target the multiple pathways which are deregulated in cancer was very useful to for identification of some pharmacologically important lead backbone that cannot be obtained by cheminformatic approaches andfurther utilized for clinical trials. This study identified the synergistic components of leads and other vital components present in the herbs increased the selectively towards cancer. This study also enriched the knowledge regarding the mechanism of action of some Indian ayurvedic herbal preparations.

Biography:

Faezeh Dadras has her experience in relationship between traditional medicine and architecture. She has worked on effects of temperament as traditional medicine grouping for human on their tendency to different environment factors. She has reached to this relationship after several experiments on human temperament and their trend to various environment factors like (color, light, material, temperature, etc.) in traditional medicine clinics. According to quick change of time and stability of propensities and general mental and physical needs of human, it is necessary for environment designers to become familiar with temperamental principles that include physical and spiritual conditions of users of spaces.

Abstract:

People with various mental and physical features show different favorites to colors. The relationship between individual features of humans and their propensities to circumstantiality of color have been evaluated in psychological discussions. According to generality of concept of temperament and covering physical and mental features of people, it seems that a significant relationship can be obtained between temperamental difference of people and their propensities to circumstantiality of color. Temperaments of 100 visitors to traditional medicine clinic at Tehran University were identified by method of doctor checkup and temperament-assessment questionnaire. Their propensities to three components of coldness and warmth of colors, light and darkness of color and contrast or uniformity in the arrangement of colors next to each other in both fields of colors selection and spaces selection with different tonality were obtained by questionnaire of assessment of temperament. Totally 100 responders with age average of 27 years old with gender of 42% male and 57% female completed the questionnaire. Wet temperaments have more propensity to light colors and also spaces with light tonality than the dry temperaments. Warm temperaments have more interest to warm colors than the cold temperaments but they prefer spaces with cold tonality. There was no significant relationship between temperamental groups and propensity to spaces with arrangement of harmonious or opposite colors beside each other. There is a significant relationship between temperamental differences of people and their propensity to circumstantiality of color. Wetness or dryness of temperament is effective on circumstantiality of lightness and darkness of color and warmth and coldness of temperament is effective on propensity to warmth and coldness of the color. Attention to temperamental propensities of people in propensity to colors can improve quality of human made physical environment and create human-based and health center space.

Biography:

Parunkul  Tunsukruthai completed her PhD (medical  sciences) in 2007 at Thammasat University Thailand. She is the lecturer at Chulabhorn International College of Medicine, Thammasat University Thailand. She has published several papers about herbal medicine, puerperium care, Thai massage to relief shoulder pain, and Acute and sub-chronic toxicity study Thai traditional formula.

Abstract:

Allergic rhinitis (AR) is a nasal mucosa inflammatory disorder that induced by an allergen exposure resulting in four symptoms including rhinorrhoea, sneezing, nasal itching and nasal congestion. Allergic rhinitis may results in sleep disturbance, fatigue, and quality of life impairment. The objective to examine the efficacy and safety in reducing allergic rhinitis of herbal steam bath compared to the steam bath, and to investigate the quality of life improvement and satisfaction in allergic rhinitis patients. A single-blind randomized controlled trial was conducted on sixty four subjects who equally allocated into two groups. The treatment group was received herbal steam bath, and the control group was received steam bath without herbs for 30 minutes 3 times a week for 4 consecutive weeks. Allergic rhinitis symptoms were measured using the Visual Analogue Scale (VAS) including itchy nose, runny nose, sneezing, nasal congestion and watery eyes at week 0,1,2,3 and week 4. Quality of life was assessed at week 0 and week 4 fond that the characteristics (sex, age, status, education, allergic rhinitis symptoms and frequency of symptoms) at the baseline were shown to be non-statistically significant. In addition, rhinorrhoea, sneezing, nasal itching and nasal congestion symptoms statistically reduced (p value<0.05), but non-significance when compared between treatment and control group. The treatment group was also shown to be significantly satisfied when compared to control group (p<0.05). Both herbal steam bath and normal steam bath had effectiveness in reducing symptoms of allergic rhinitis, and were safe to be used as an alternative treatment for allergic rhinitis.

Biography:

Khaled Abo-EL-Sooud is a Prof of Pharmacology, Faculty of Vet. Med. Cairo University. He supervised several Master and Ph.D. theses in Egypt and Arabian Countries. He is expertise in Radioisotopes and Chromatography (GC-HPLC-TLC etc.) for detection of drug residues. He is publishing about 66 international papers. Nowadays, the research is shifted to nanotechnology and phytomedicine. Member of Ministry of Health and promotion committee of Supreme Council of Universities committee.

Abstract:

Central nervous system (CNS) depressant drugs have many negative side effects including addiction, depression, suicide, convulsion, sexual dysfunction, headaches and more. Moreover, these agents do not restore normal levels of neurotransmitters but instead influence the brain chemistry. In contrast to drugs, a number ethno-botanical products have been identified which reduce anxiety by re-establishing by altering both neurotransmitter levels in the absence of the severe side effects. The bitter orange fruit (Citrus aurantium) contains a number of phytochemicals of interest known to increase the production of dopamine. The purpose of this study is to evaluate Citrus aurantium L. oil ability to induce sedative/hypnotic and/or general anaesthetic effects in experimental models. Methodology & Theoretical Orientation: Essential oil from peel was obtained by steam distillation, then maintained and protected against light and heat until the pharmacological assays. The main component of the oil was determined by GC-MS. The LD₅₀ of the oil was determined to calculate the therapeutic dose. Experimental models were performed in this study to evaluate the hypnotic and anesthetic effects of C. aurantium as compared with thiopental sodium at a dose of (30 mg kg^-1) after intraperitoneal injection (I/P). Findings: The LD₅₀ of the oil was 300 mg kg^-1 of body weight after intraperitoneal injection (I/P). The main component of the EOP was d-limonene. The CNS depressant effect of C. aurantium oil is dose dependent. At small dose there was an induction of hypnosis as righting reflex was absent with ataxia. At higher doses the oil induced anesthesia at 8 min and the consciousness is regained in about 25 minutes. Conclusion & Significance: The use of animal model of hypnotic and ultra-short general anaesthetic of C. aurantium oil significantly supports its use an adjunct for the treatment of insomnia and other CNS disorders. Recommendations: Further evaluations are required to elucidate the detailed mechanism of CNS depressant activity and possible side effects of Citrus aurantium and the possibility of its use as alternative natural general anesthetic agent.

Biography:

Akihito Iino has graduated Arizona (USA) integrative medicine fellowship in 2014 and Akita medical University (Japan) in 1998. He is a medical doctor, child psychiatrist of Shimada ryoiku center. He has a qualification of Japanese national psychiatrist, child psychiatrist, pediatrician. Additionally, he has a qualification of energy healer at master’s level, hypnotherapist at upper level in Japan. He translated one book of CAM medicine for psychiatric clients, published two medical papers written in Japanese.

Abstract:

Shimada ryoiku center is the child rehabilitation hospital, established in 1963, 1st private hospital for child rehabilitation in Japan. We daily use Kampo for lots of inpatients and outpatients.

At outpatient department, we have 190 patients every day, 46000 patient every year. 49% patients receive drugs, 63% execute rehabilitation of PT,ST,OT,counseling. 36% go to pediatrician, 47% go to child psychiatrist. Child psychiatrists in our hospital use no.1 Yokukansan, 2 Yokukansan-Katinpihange, 3 Syokentyutou. Target symptoms are 1 irritation, 2 insomnia, 3 child infirmity. Kampo 1 and 2 contains Uncaria Thorn(釣藤鈎,Tyoutoukou), this component shows anti-anxiety effect through 5-HT2A. All contains licorice (Kanzou), which reduce tension. Japanese Kampo combinations almost warm up the body of clients. The biggest barrier to use Kampo for children is 1 bitter taste, 2 poor drug management by parents, 3 taking time for beneficial effect. But they are cheap, their price is about 10% from nerve-stimulants, Kampo doesn’t give a financial burden for the family and the government. Under Japanese national healthcare insurance system, outpatient children need 2USD for medical exam and drug.

Next, 232 inpatients stay in our hospital now. They are disabled, have a number of congenital disease, they are accommodated for average of 33 years, because of family problem, abandoned, financial problem etc. 20% inpatients received Kampo, but there are very few side effect.

Dr.Obitu surgical and homeopathy doctor said {CAM is a gentle, moderate medicine}. Few medical evidence (DBRPC), very few side effect, very few money (cheap) , Kampo is of great use for children.

Biography:

Professor (Dr.) Prem P. Rai formerly served at the University of Papua New Guinea, School of Medicine and Health Sciences. He is currently Dean of the School of Natural Resources & Applied Sciences at Solomon Islands National University. His speciality includes pharmacognosy and quality control aspects of herbal medicine. Dr. Rai headed the traditional medicine program of the National Department of Health in Papua New Guinea for over 15 years. He is an active researcher and has published more than 98 papers and authored number of technical books including one on Medicinal Plants in Papua New Guinea, published by the World Health Organization. Dr. Rai serves as an advisor and member on editorial board of number of local and international scientific journals.

Abstract:

The Traditional Medicine Database (TMD) was established in 2000 to document, preserve and encourage the use of safe and effective traditional medicine practices and ethno-botanical tradition in Papua New Guinea (PNG). One of the early challenges that restricted incorporation of traditional medicine in primary health care program was insufficient documentation about medicinal plants usage as traditional medicine. This has now been addressed by carrying out systematic documentation and maintaining a comprehensive inventory and record of information on local uses of medicinal plants and traditional medicine practices, and by collecting and storing information from the practitioners nationwide to ensure that local knowledge is preserved, researched and properly promoted to community at large. The TMD is extensive, fully referenced, and provides historical use fields and published research information. Specifically, the electronic database contains taxonomical, ethno-botanical, phytochemical, and biological activity data including medicinal uses of herbs with methods of preparation, administration, dosage, frequency, etc. An interesting feature is the plants image file containing pictures of plants taken in their natural habitat. Over the years the TMD has emerged not only as the repository of indigenous knowledge in traditional medicine but has become an important resource for scientific researches on host of medicinal plants. It has also proven to be a useful tool for identifying safe and effective herbs. Many herbs such as Alstonia scholaris (severe fevers), Evodia elleryana (anti-TB, cough and fever), PNG lichen, Parmotrema saccatilobum (analgesic and anti-inflammatory), Ageratum conyzoides (diarrhoea and dysentery), Vocanga papuana (antibacterial), anti -HIV herbs such as Derris elliptica and many others have been investigated, and traditional uses and claimed therapeutic properties substantiated. A well-developed TMD can be an excellent resource in selection of herbs for scientific researches and to provide rationale for host of traditional medicines.

(*formerly with The University of Papua New Guinea)

Biography:

Prof. Edwin David Benher is working as Associate Professor and Head, Research Department of Zoology, Virudhunagar Hindu Nadars’ Senthikumara Nadar College (Autonomous), Virudhunagar, Tamilnadu (India) since 1988. To his credit, he has published more than 5 research papers in national and international peer reviewed journals. He has participated and presented his research papers in many National Conferences held in India. Currently he is pursuing research leading to Ph.D Degree in Zoology at Alagappa University, Karaikudi, Tamil Nadu (India).

Abstract:

Diabetes is an important and very common disorder among the human beings that are associated with high blood sugar levels which often leads severe complications to the human body. It can also bring serious consequences including death. The main aim of the present study was to document the indigenous knowledge on the usage of medicinal plants to cure diabetes. In the present study, a total of 44 species of plants belonging to 15 families were documented. As far as plant part utility is concerned, leaves are commonly used, followed by bark, whole plant, seeds etc. The formulations are prepared mostly in the form of juice followed by decoction, powder and paste prepared from raw plant parts. To make better acceptability of herbal remedies that are taken orally and additives are not taken internally. The data collected from this study will be useful to the researchers, pharmaceutical companies to discover a novel drug to cure diabetes. 

Biography:

Dr. Palanichamy Mehalingam completed his Ph.D Degree in Botany from Madurai Kamaraj University, Madurai in 2000. Currently he is working as Assistant Professor in Botany, Virudhunagar Hindu Nadars’ Senthikumara Nadar College (Autonomous), Virudhunagar, Tamilnadu (India). He has produced 25 M.Phil and 9 Ph.D Scholars and also guiding 4 Ph.D Scholars. He has published more than 65 research papers in reputed journals. He has participated and presented his research papers in International Conferences held in The Netherlands, Malaysia, Thailand, China and Lao PDR. He undertook his Post Doctoral Studies (UGC Research Award) at the Department of Botany, VHNSN College (Autonomous), Virudhunagar during 2014-2016. He has been engaged in research on ethnobotany, pharmacognosy, pharmacology and phytochemistry.

Abstract:

An ethnobotanical survey of medicinal plants used in curing skin diseases was carriedout among Paliyar tribes in Theni district, Tamilnadu (India). The indigenous knowledge of local traditional healers and the native plants used for medicinal purposes were collected through personal interviews during field trips. The plants were arranged family wise followed by botanical name of the plants, locality, ethnomedicinal use in briefs and local name. The voucher specimens have been deposited in herbarium of Department of Botany of VHNSN College (Autonomous), Virudhunagar. The collected plants were identified with referring standard compilations. Plants have been used as healers and health rejuvenators since time immemorial. A total of 65 plant species belonging to 37 families are described along the method of drug preparation, mode of administration, probable dosage and duration of treatment. The aim of the present study is not only to prescribe the remedies for skin diseases in human beings but also an endeavour to draw attention for the need of detailed study on medicinal plants of the area, which could provide better and efficient remedies for many dreadful diseases. This study concluded that many people in studied parts of Western Ghats of Theni district still continue to depend on medicinal plants at least for the treatment of primary healthcare. The traditional healers are dwindling in number and there is a grave danger of traditional knowledge disappearing soon since the younger generation is not interested to carry on this tradition. Hence, It is urgent need for documenting these before such valuable knowledge becomes inaccessible and extinct.

Biography:

Dr. Natarajan Nirmalkumar obtained his Doctoral Degree in Botany from Manonmaniam Sundaranar University, Tirunelveli in 2008. At present he is working as Assistant Professor in Botany, Virudhunagar Hindu Nadars’ Senthikumara Nadar College (Autonomous), Virudhunagar, Tamilnadu (India). He has produced 10 M.Phil and also guiding 2 Ph.D Scholars. To his credit, he has published more than 35 research papers in national and international peer reviewed journals. He has participated and presented his research papers in International Conferences held Lao PDR. He is also serving as reviewer in peer reviewed journal. He has been awarded with Bharat Research Award by TRUST, India for his outstanding contribution for the protection of environment.

Abstract:

The present study was aimed to document the medicinal plants which were used to cure diseases in cattle by the traditional healers in Virudhunagar district, Tamil nadu (India). Information on medicinal plants was collected from the traditional healers by adopting semi-structured questionnaire and through open-ended interview. It is evident from the data that leaves constituted the major plant part used (52%) followed by whole plant (34%) and barks (14%). These plants were used to treat appetites, bloat, fever, ephemeral fever, diarrhoea, dysentery, cough, foot  and mouth diseases. About 25 traditional healers were interviewed. From this study, a total of 60 plant species belonging to 26 families were used and described along with drug preparation mode of administration, dosage and duration of the treatment. The main purpose of this study was not only documenting the ethnomedicinal plants used by traditional healers but also maintain with traditional knowledge for the conservation and sustainable utilization of the promising medicinal plants in these area  and also for effective treatment of various ailments in cattle.

Biography:

Massage Therapist/Craniosacral Therapist/Equine Bodyworker/Certified Lymphedema Therapist/Certified Athletic Trainer 27 years of injury care as an Athletic Trainer and Massage Therapist: Olympic, Paralympic, College, High School, Sportsmedicine Rehabilitation Craniosacral Therapist  treating various issues including pain, insomnia, high blood pressure, anxiety, PTSD, brain injury, Alzheimers, Tinnitus. Specific program treating Veterans as part of a recovery retreat combining horses-counseling-craniosacral therapy. The program is being adapted to treat breast cancer recovery

Equine Bodywork Therapist treating horse’s tissue and joint tension to assist in injury recovery and improved performance

Publication “A case study utilizing myofascial release, acupressure and trigger point therapy to treat bilateral “Stringhalt” in a 12 year old Akhal-Teke horse.” Journal of Bodywork & Movement Therapies. (2016)

Abstract:

INTRODUCTION

“Stringhalt” is a horse condition that causes one or both hind legs to spasm when walking, trotting or backing. The condition is thought to be related to a neurological cause from either plant toxicity or peripheral nerve injury. The prognosis is poor and the horse’s performance and quality of life can be affected. Treatment has included surgically cutting the digital extensors with varied results.

The objective of the study is to utilize soft tissue release via acupressure, trigger point and myofascial release to decrease symptoms of stringhalt.

CASE PRESENTATION

The case study is a 12 year old Akhal-Teke horse of excellent pedigree. In 2011, she was caught in barbed wire overnight and sustained lacerations to the bone. Shortly after the injury the horse was placed in a stall for several months and was unable to walk or run, developing stringhalt. Currently, her condition is aggravated by stress and alleviated by certain types of massage (myofascial, acupressure, trigger point release). The incidence of stringhalt occurs every 3-5 minutes, with more frequent and severe symptoms on the right hindlimb. The horse is unable to run or back up. 

METHODS

6 treatments biweekly were performed at 1 to 1 ½ hour sessions. The treatments consisted of myofascial release at the cervical, sacrum and iliums, acupressure of the bladder meridian (including c-spine, t-spine, L-spine, and hamstring), and trigger point release of the iliacus. The stringhalt motion was observed and documented on each of the 6 treatment days for 30 minutes.

RESULTS

After 6 treatments, the horse was seen running and standing in a position that promotes hip extension. She has not been able to do either since the injury. The frequency and severity of the spasms have decreased from every 3-5 minutes to every 10-20 minutes. The horse’s owners report that her disposition, stress and quality of life are much improved.

DISCUSSION

The results suggest that myofascial release, acupressure and trigger point therapy may be utilized to provide a positive treatment outcome in the case of stringhalt. However, please note that the scope of practice varies by state and special training is needed to work with the equine population.

Biography:

Doctor of chiropractic (AECC) and physiotherapist (Munich) with special interest in Sports Medicine in private practice based in Cardiff/Wales. Chiropractor at the World Games Cali, 2013; London 2012 Olympic Games; Paralympic Games and World Championships. Very experienced in working with International, Premier league footballers, professional golfers, athletes, sports coaches and company executives.

Education: 2113 -2016 Diploma in Sport and Exercise Medicine, Cardiff Metropolitan University

2009 -2011 MSc Sports and Rehabilitation, Bournemouth University

1992 -1996 BSc Chiropractic, Anglo-European College of Chiropractic,

1985 -1988 Dip Physiotherapy, Orthopedic Hospital, Munich

Specialties: Sports injuries, low back pain, sciatica,

Abstract:

Design: Survey design, quantitative research.

Background: Recent research findings indicate that mental hardiness can be determined reliably with the use of specific self-assessment questionnaires.

Objectives: The objectives of the present study were to determine the level of mental hardiness in a group of professional soccer players using two established questionnaires (modified Sports Mental Toughness Questionnaire (SMTQ-M) and Psychological Performance Inventory (PPI-A)) and to investigate the degree of correlation between the scores of these two measures. Further, the study aimed to establish the level of inter-rater agreement between two coaches in rating the level of mental hardiness of their players, and whether the results of the players’ self-assessments agreed with the coaches’ ratings.

Setting: A professional championship football club in Wales.

Subjects: Convenience sample of 20 professional soccer players and two football coaches.

Methods: After written and witnessed consent, two self-assessment questionnaires (modified PPI-A and SMTQ-M) were completed by the football players. Two coaches, who did not know the outcome scores of the players’ self-assessments, independently rated each player. Each player was awarded a percentage score for each test, and an average percentage score ({SMTQ-M % + PPI-A %} ÷ 2). Mean scores were established for the whole team, International players and Non-International players. The PPI-A and SMTQ-M scores obtained for each player were analyzed for correlation with Pearson’s correlation. The ratings of the coaches were analyzed for agreement with Kappa-statistics. Finally, the data were analyzed with Kappa-statistics to determine whether the players’ self-ratings agreed with the coaches’ ratings.

Results: The average ({SMTQ-M % + PPI-A %} ÷ 2) mean score was 77 %, (SD = 7.98). The independent t-test (p = 0.04) showed that international players scored on average 7.4 % higher than non-international players. The players’ scores obtained from the PPI-A and SMTQ-M correlated well (r = 0.709, p < 0.001). The ratings of the players by the two coaches showed a significant, but weak to moderate agreement (Cohen's kappa = 0.33). No statistical significant agreement was found between player self-assessments and the ratings given by the coaches.

Conclusions: There is significant correlation between SMTQ-M and PPI-A scores. The levels of mental hardiness in professional football players can be assessed with both questionnaires. Higher performers had a slightly higher mental hardiness score. The results would suggest that either coaches were not able to judge the mental hardiness levels of their players appropriately, or that the players over- or under-rated their own mental hardiness and therefore, made it impossible for coaches to concur with the players’ self-ratings.

Biography:

Ming-Cheng Lin has his expertise in the field of toxicology, especially in studying the toxic effects of the herbicide of paraquat on the influences of the level of essential trace element and antioxidant enzyme activity. He has recently paid more efforts on exploring the protective mechanism of some Traditional Chinese Medicines on cerebral ischemic insult.

Abstract:

Statement of the Problem: Recent investigation has demonstrated that Antrodia Camphorata (AC) has received a great deal of attention due to its beneficial effects such as anti-inflammation and anti-oxidation. Excessive transition metal level of iron (Fe) and copper (Cu) has been proposed to be harmful to the health. In this current experiment, we hypothesis that neuroprotective mechanisn of AC is associated with reducing level of Fe and Cu, and enhancing antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) in the ischemic brain. Methodology & Theoretical Orientation: Male Sprague-Dawley rats were divided into control and AC-treated subject. Both groups were intraperitoneally injected with saline and AC for 14 days, respectively. On day 15, cerebral ischemic surgery was performed by occlusion of right middle cerebral artery (MCA) and right common carotid artery (CCA) for 1 hour. After completing surgery, rats were sacrificed and right brain cortex was isolated followed by homogenates. Supernatants were collected and ready for analysis of Fe and Cu level. Meanwhile, enzyme activity of SOD, CAT, GPX, and malondialdehyde (MDA) level were measured. Conclusion & Significance: Obtained data showed that level of Fe, Cu, and MDA was obviously declined (P < 0.05) in AC-treated subject. Conversely, a statistical (P < 0.05) enhancement of the enzyme activity of SOD, CAT, and GPX was found in AC-treated group. Based on our current findings, it seems likely to manifest the possibility here that neuroprotective mechanisms of AC are associated with declining Fe and Cu level together with enhancing enzyme activity of SOD, CAT, and GPX on the ischemic brain.

Biography:

Prof  Sulukkana  Noiprasert at Mae Fah Luang University MFU, Thailand. She Studied at Nanjing University of Chinese Medicine and Studied Faculty of Medicine at มหาวิทยาลัยเชียงใหม่

Abstract:

Objective

To compare the effectiveness difference between moxibustion and auricular acupressure in the patients with primary dysmenorrhea.

Methods

Fifty three students with the diagnosis of primary dysmenorrhea were recruited for the study. Their dysmenorrhea severity was rated by visual analogue scale (VAS) immediately prior to entry into the study. They were randomly divided into two groups; and the following menstrual cycle they were given auricular acupressure treatment (experimental group, n=31) or moxibustion treatment (control group, n=22). The auricular acupressure was applied to uterus, liver and shenmen point for 7 days before menstruation and the moxibustion was applied to guanyuan(GV4) for 15 min, once daily for 7 days before menstruation. After treatment VAS score was rated again during menstruation in both groups.

Results

There was no statistically significant difference in VAS score between two groups (p>0.05) before treatment.  After one menstrual cycle treatment, VAS score were significantly decrease in both groups (p<0.05). Mean pain scores decreased by 59.5% and 44.1% in the auricular acupressure group and moxibustion group, respectively. Between two groups, there was no statistically significant difference in the VAS score (p>0.05) after treatment.

Conclusion

Auricular acupressure was as effective as moxibustion for pain relief in the patients with primary dysmenorrhea. Thus, the use of auricular acupressure should be promoted in treating primary dysmenorrhea.

Key words: auricular acupressure, moxibustion, primary dysmenorrhea

Biography:

Dr. Nadia Mohd Effendy obtained her Bachelor’s Degree in Biomedical Sciences from Universiti Kebangsaan Malaysia (UKM) in 2011 and Doctorate degree in Pharmacology in 2014 at the age of 25, from the same University. She was appointed as Assistant Professor at Cyberjaya University College of Medical Sciences from 2014-2015. She is currently Senior Lecturer in Faculty of Medicine & Health Sciences, Islamic Science University of Malaysia. She has many experiences in presenting research talks and papers at national and international conferences. She has also published tremendous articles in highly esteemed journals. Her research interests are on Pharmacology, Alternative & Complementary Medicine, Toxicology, Radiology, Drug Metabolism and Bone Metabolism.

Abstract:

Background: Labisia pumila var. alata (LP) has shown potential as an anti-osteoporotic agent in recent years. The crude extract of LP was reported to reverse trabecular microarchitecture changes induced by ovariectomy. The mechanism is still unclear but it may be elucidated by examining the bone molecular pathways. This study aimed to evaluate the bone-related genes and pro-inflammatory cytokines expressions to provide a mechanistic overview on how the different LP extracts could prevent degenerative bone changes. Methods: Forty-eight female Sprague-Dawley rats were randomly divided into sham-operated (Sham), ovariectomized control (OVX), ovariectomized and given oestrogen at 64.5µg/kg (ERT), ovariectomized and given LP aqueous extract at 100 mg/kg (LPaq), ovariectomized and given LP methanol extract at 100 mg/kg (LPmet) and ovariectomized and given LP ethanol extract at 100 mg/kg (LPet) All treatments were given daily via oral gavages for nine weeks. Rats were then euthanized and femora dissected out for genes and cytokines expressions analysis.  Results: Among the extracts, LPaq was found to produce the highest expressions of OPG, osteocalcin, osterix, osteonectin and ALP. LPaq was also shown to down-regulate the expressions of RANKL, MMP9, M-CSF as well as cytokine IL-1β. Conclusion: Aqueous extract is the best extract of LP which may exert anti-osteoporosis activity by regulating the bone-related genes and cytokines expressions.

Biography:

Edward Laurence Opena has been teaching college biology for 10 years. He taught various biology subjects such as general biology, plant physiology, animal physiology, immunology and taxonomy. Aside from teaching, he is also academically active as a university researcher, whose research studies is focus on plants. His current research study is on leaf shape analyses and the effects of magnetic field on the physiology of economically-significant crops such as Brassica species. His hobby is on nature photography and filmmaking.

Abstract:

Euphorbia hirta’s effects on the blood chemistry in albino mice (Mus musculus) had been investigated in this study. There were 15 mice per gender (10 experimental, 5 control). 0.5 mL of the 1:10 g:mL decoction was administered after 40 days of acclimatization. Approximately 2 hours after the oral administration of the extract, 0.5 mL of blood was obtained through intracardiac extraction. Laboratory tests showed that in males, only K showed significant decrease and none in females (p=0.001). Analyses on the degree variation between male and female, significant changes were observed to have occurred in their levels of creatinine, blood urea nitrogen, and uric acid (p=0.048, 0.035, 0.006, respectively). Highest electrolyte decrease was male’s K (26.5%), and female’s UA for blood chemistry (30.1%), while highest increase males’ Na and females’ BUN was observed (7.9% and 25.5%, respectively). It is then hypothesized that hormones may play in the blood chemistry and not much in the electrolytes. Further, it could also be that the extracted molecules do not react on individual molecules, rather than more complicated molecules such as those in the blood chemistry. Using other extracting method and longer periods of extract administration can be considered for further investigation.

Biography:

Dr.Ratnaprabha S. Chaudhari, completed B.A.M.S. (Ayurvedacharya), M.D.(A.M.)

P.G.D.E.M.S. (Post graduate diploma in emergency medical services),

P.G.D.I.H.M. (Post graduate diploma in industrial health management),

Practicing core in infertility, skin and hair care.

Director-Havya Ayurvedacharya, specialized preventive clinic,

Researcher in skin problems

Presented research paper in April-2017 at London, UK Ayurveda conference

Presently working on Psoriasis and stress factor treatment

Published papers in many ayurveda magazines, related infertility and skin care

Active member of many national and international organizations

Abstract:

Nowadays, infertility has main impact on society and world. Infertility either in male or females causes generalized impact on family health.

Ayurveda is science of traditional Indian herbs which includes herbal medicines with some procedures of panchkarma which helps not only cures but prevents disease and its complications.

Infertility and ayurveda correlates in different ways to treat. Important aspect is detoxification of body to grow healthy ovum and sperm which leads to healthy child. And so detoxification of male and female both, pooves very good results in treating infertility.

But, in many cases with some complications related hormonal imbalance or physical problems proved to be treated very well with internal ayurvedic herbs along with panchkarma. Male and female infertility are two individual groups which can be distinguished and treated accordingly. Medicinal herbs and panchkarma varies in

Also specific dietary herbs that can improve fertility are advised to give additive effects in results.

Thereby, infertility treated with internal herbs, dietary changes and detoxification by panchkarma gives almost positive results in many cases.

Biography:

Fanyana Mtunzi has completed his PhD at the age of 32 years from University of North-West (South Africa) He is the Senior Lecturer and Researcher at Vaal University of Technology. He has published more than 30 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract:

Medicinal plants provides valuable alternative as sources of drugs and drug discovery since many have been used in traditional practices for centuries to manage or cure various forms of ailments. Plants in this research were selected on the basis of an ethno-botanical survey based on questionnaire responses and verbal interviews that was conducted in Mabandla village in KwaZulu-Natal, South Africa. Bioassay guided study involving anti-inflammatory studies measurements of LOX activity effected by a reaction medium containing 15-LOX, linoleic acid in buffer at pH 9 for 30 to 90 seconds after adding plant extract/fraction, free radical scavenging capacity against the ABTS^●+ radical cation and DPPH^● radicals; antimicrobial and bioautography assays against Staphylococcus aureus, ATCC 29213, Pseudomonas aeruginosa ATCC 27853, Enterococcus faecalis ATCC 29212, Escherichia coli, ATCC25922, Candida albicans and A. fumigatus were carried out on the plants extracts, fractions and pure compounds. Isolation of compounds displaying biological activity was also carried out by use of open column chromatography and preparative TLC. The compounds were characterised by use of Nuclear Magnetic resonance, NMR, Mass Spectra, and Infra-red (IR) spectroscopy.

The DPPH sprayed TLC displayed that all the nine plants contain antioxidants most of which are contained in polar fractions of acetone and methanol. Results of the assays displayed a range of biological activities comparable to the positive controls used for each assay. DPPH^● scavenging displayed EC₅₀ values ranging between 1.008 and 467 mg/L. The highest activity is obtained from methanol fraction of Berkheya setifera with EC₅₀ value of 1.008 mg/L within 0.5376 to 1.890 at 95 %confidence limit followed by crude fraction of Gunnera perpensa with EC₅₀ value of 1.069 mg/L within 0.5222 to 2.188 at 95 % confidence limit. Carissa bispinosa hexane fraction displayed the lowest activity of 467.7 mg/L within 264.0 to 828.5 at 95 % confidence limit. Highest ABTS^●+ radical scavenging was demonstrated by Pomaria sandersonii DCM, (1.273 mg/L at 0.9439 to 1.719 within 95% confidence limit) for the Ethyl acetate, (5.973 mg/L at 4.722 to 7.555 within 95% confidence limit while the lowest activity was displayed by hexane fraction from Eucomis autumnalis (929.4 mg/L at 557.5 to 1550 within 95% confidence limit)The activity of Pomaria sandersonii extracts and fractions demonstrated that the plant contains antioxidants that react with both DPPH and ABTS radicals although higher activities were shown by ABTS as displayed by the lower EC₅₀ values. All of the crude fractions and extracts displayed high to moderate anti-bacterial activity (20 -625 µg/ml) and anti-fungal activity (20 -2500 µg /ml). P. sandersonii crude and fractions demonstrated highest antimicrobial activity compared to other plants. Some MIC values P. sandersonii DCM and ethyl acetate (80 µg /ml in each case) compared well with gentamycin (4 µg /ml) same value against S aureus, E. faecalis, E Coli and P aeruginosa. Anti-fungal activities of the DCM, acetone and methanol fractions were also highly active (20 µg /ml) for both C. a. and A. f. Inhibition of pathogen growth demonstrated by the polar fractions indicate that most of the active compounds would be soluble in water. P. Prunelloides, crude methanol extract produced 60% sucrose component and G. perpensa, 36% was glucose. Three compounds isolated from Alepidea amatymbica and three from Pomaria sandersonii which displayed high antimicrobial activities.

Biography:

Prof. Gurcharan Kaur has scientifically validated the Indian traditional practices of Natural products from medicinal plants. Her laboratory presented the first ever pre-clinical evidence for Withania somnifera and Tinospora cordifolia extracts as potential agents with capability for neuronal differentiation, an attractive supplementary therapeutic approach for the treatment of brain cancers. An in vivo study from her lab explored the anxiolytic and immunomodulatory potential of ASH-WEX in acute sleep deprived female Wistar rats. ASH-WEX treated animals showed reduced anxiety in Elevated Plus Maze test along with reduction in expression of pro-inflammatory cytokines TNFα, IL-1β and IL-6. ASH-WEX was also instrumental in enhancing cell survival and reducing apoptosis as witnessed from downregulation of NFκB, AP-1, cytochrome c and upregulation of Bcl-xL. Her detailed mechanistic studies of potential interventions by natural products promise to offer a unique therapeutic strategy in amelioration of neuroinflammation and neurological disorders associated with obesity and sleep disorders.

Abstract:

Search for herbal medicines that may act as therapeutic agents is an active area of research to combat the diseases such as stroke, head trauma, multiple sclerosis and various neurodegenerative disorders. Ashwagandha (Withania somnifera) has a long history of rejuvenating health in Ayurveda, the traditional system of medicine in India. The ongoing study in our lab is aimed to investigate the mechanisms by which Withania somnifera leaf water extract (ASH-WEX) may confer protection against LPS induced neuroinflammation. Microglial BV2 cell line was tested for anti-inflammatory and anti-excitotoxic potential of ASH-WEX. Cell viability and the expression of glial and microglial cell differentiation markers was examined in LPS activated cells in the presence and absence of ASH-WEX. We demonstrated that LPS challenged microglia cell line BV2, and glial cell line C6 Glioma when exposed to LPS, undergo activation that was accompanied by change in cellular morphology and specific markers expression such as GFAP, Iba 1, tubulin as well as transcription factors like AP-1, NF-kappaB, c-jun,, c-fos etc. Further the expression of plasticity markers NCAM and PSA-NCAM was evaluated to establish their role in ASH-WEX mediated neuroprotection. The study was further extended to explored the in vivo effects and the expression of key inflammatory molecules (NF-κB, Iba1, TNFα, IL-1β, IL-6), glial markers (Iba1, GFAP) were studied in the hippocampus and pyriform cortex (PC) regions of rat brain exposed to LPS and ASH-WEX treatment. The data suggests that ASH-WEX or its active components may have therapeutic potential for prevention of neuroinflammation and neurodegeneration associated with neuroinfections

Biography:

Will be updated soon

Abstract:

Prevalence of urinary stone or renal calculus in India is approximately 5-6 % and day by day it is increasing. Changes in dietary practices may be a key driving force.

Ayurveda as well as surgical interventions have very good treatments for removal of renal calculi. But the recurrence of the disease is the main problem in front of the patients and physicians. ‘Rasayana’ or ‘Apunarbhava Chikitsa’ (i.e. treatments used to prevent diseases) are time tested  Ayurvedic treatments for prevention of diseases. This made us to think about effective treatment to counter the recurrence of renal calculi. In literary search of Ayurvedic texts, it is found that various Yapana Basti are directly indicated as  Rasayana for many diseases. It was hypothesized that  Mustadi Yapana Basti could  be used as a Rasayana or Apunarudbhava Chikitsa for recurrence of  Mutrashmari as the Dravya used in preparation of Mustadi Yapan Basti have got Gamitva i.e. affinity  towards Mutravaha Srotas. Study was carried out on five patients who were suffering from renal calculi for consecutive two to three years, but at the time of registration for this study were free from urinary stones. Total sixteen Basti were administered. Patients were observed for next one year. Very encouraging results were observed. None of them showed recurrence.  Even though number of patients is very less; it can be concluded that,  Mustadi Yapana  Basti can definitely prevent the recurrence of renal calculi.

Biography:

Will be updated soon

Abstract:

Chronic Hepatitis B (CHB) is a viral infection caused by hepatitis B virus (HBV) which produces a chronic necro-inflammatory condition in the liver. A number of Unani formulations have been used successfully in the treatment of hepatitis in Unani medicine since centuries. India has second highest HBV infected population after China with over 40 million hepatitis B infected patients and alone contributes 9% of the total CHB cases of the world. Most people with CHB in India are unaware of their HBV infection, putting them at a serious risk of developing cirrhosis or liver cancer which are life threatening. Antiviral drugs such as entecavir, tenofovir, interferon etc. leads to kidney deterioration, nausea,  vomiting, thrombocytopenia, resistance on prolong usage as well as highly expensive when used for longer duration. We have evaluated the therapeutic efficacy of decoctions of Unani herbal drugs in the management of chronic hepatitis B in 30 patients. Decoctions were given orally for morning and evening dose for 3 months. Test drug was evaluated for its efficacy and safety on HBsAg, HBeAg, HBV DNA, liver function test (LFT), kidney function test (KFT), blood sugar, haemogram and urine examination at 45 days and 3 months. Highly significant results were observed on HBsAg, HBeAg, HBV DNA, liver function test (LFT) which provide evidence that the decoction of Unani herbal drugs had antiviral, anti-inflammatory, hepatoprotective and analgesic effects. The test drugs were found safe and effective for the treatment of chronic viral hepatitis B.

Biography:

Dr. Amulya Dahal is currently working as Ayurveda Medical Officer in Sankhuwasabha, Nepal. He completed his Bachelor Degree in Ayurveda Medicine from Ayurveda Campus, Institute of medicine, Tribhuwan University in 2015. He has many experiences in presenting research talks and papers at national and international conferences. He has published more than 5 research papers in reputed journals.His research Interest are on Ayurveda Medicine, Ethno-medicine, Ethno-Veiterany medicine, Pharmacology, Toxicology and Yoga.

Abstract:

Arsha (Hemorrhoids) is a very common ano-rectal condition affecting as much as half the population by age of 50, and represent a major medical and socioeconomic problem. Many treatment methods have been applied in management of Arsha (Hemorrhoids) disease ranging from dietary and lifestyle modification to para- surgery and surgery, dependingon degree and severity of symptoms. It has been proved by scientific studies that Changeri (Oxalis Corniculata) improve microcirculation, capillary flow, and to strength the surrounding connective tissues of anus and lower rectum. The present case study deals with the oral supplementation of Changeri Ghrita in Arsha (Hemorrhoids) patients, which has prevented the expensive, time-consuming, painful management of Hemorrhoids with good result in symptomatic management of Arsha (Hemorrhoids).

Biography:

Will be updated soon

Abstract:

For many years medicinal plants have become a research interest and focus especially for providing primary healthcare needs. This study was carried out to determine the phytochemical properties as well as the antibacterial activities of methanol and ethanol extracts of the dried roots of Anthocleista djalonensis. The whole dried roots specimen of Anthocleista djalonensis was extracted using soxhlet extraction apparatus. These extracts were further screened for antibacterial activity using agar well diffusion technique. Twelve clinical and typed strains of bacteria isolates were tested for susceptibility to these extracts. The bacteria strains used were; Bacillus cereus (NLCC 14724), Bacillus cereus (NLCC 14725),Staphylococcus aureus, typed Staphylococcus aureus, Salmonella typhi, typed Salmonella typhi, Escherichia coli, typed  Escherichia coli, Psedomonas aeruginosa, typed Psedomonas aeruginosa, Bacillus subtilis, Proteus mirabilis.

However, both extracts had significant antimicrobial activity (p<0.05) on ten out of the twelve isolates which includes Bacillus cereus (NLCC 14724), Bacillus cereus (NLCC 14725), Staphylococcus aureus, Salmonella typhi, typed, Escherichia coli, typed Escherichia coli, Psedomonas aeruginosa, typed Psedomonas aeruginosa, Bacillus subtilis, Proteus mirabilis. The typed strains of Staphylococcus aureus and Salmonella typhi were not susceptible to any of the extracts.

Meanwhile, the phytochemical analysis revealed the presence of tannin, saponin, reducing sugar, alkaloid, flavonoid and glycosides. These compounds have been found to be responsible for the antibacterial activity of the extracts.

Biography:

Dr Johanna Bapela is a full time permanent lecturer at the Department of Plant and Soil Sciences of the University of Pretoria, South Africa. Her research area is mainly focussed on bioprospecting indigenous plant species for antiprotozoal chemotherapeutic agents. She is an affiliate of University of Pretoria Institute For Sustainable Malaria Control (UP ISMC) and Medical Research Council Collaborating Centre for Malaria Research, which collectively coordinate and promote collaborative research on safer and sustainable malaria control and management strategies, and to generate new knowledge and support new activities pertaining to safe malaria control in Africa

Abstract:

Vector-borne infectious diseases remain the main public health problem affecting many people in tropical and subtropical regions. Chemotherapy is still one of the fundamental measures used in the control and treatment of protozoal diseases; however, the emergence of resistant strains is compromising its effectiveness. The main aim of this study was to bioprospect South African indigenous plant species for novel antiprotozoal plant products. Twenty plant species were collected, extracted in dichloromethane: 50% methanol (1:1) and then separated into polar and non-polar fractions. The acquired crude extracts were tested on Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani and Plasmodium falciparum. The current study is the first scientific account on the significant antileishmanial efficacy (IC₅₀ ≤ 5 µg/ml) of Bridelia mollis, Vangueria infausta subsp. infausta, Syzygium cordatum and Xylopia parviflora, as well as high antitrypanosomal activity of Albizia versicolor. Ten plant extracts exhibited significant in vitro antiplasmodial activity, with Tabernaemontana elegans and V. infausta subsp. infausta being the best samples. Application of supervised Orthogonal Projections to Latent Structures–Discriminant Analysis (OPLS-DA) on the 1H NMR profiles resulted in a discrimination pattern that could be correlated to the observed antimalarial bioactivity. Further phytochemical analyses let to the isolation of dregamine and tabernaemontanine from T. elegans as well as friedelin and morindolide from V. infausta subsp. infausta. The study demonstrated the potential of discovering novel antiprotozoal scaffolds from medicinal plants

Biography:

Kokoette Bassey has completed his PhD from Tshwane University of Technology and is currently a Senior Lecturer at Sefako Makgatho Health Sciences University. He has published 3 papers in reputed journals and has reviewed twice for the South African Journal of Ethnopharmacology

Abstract:

Hypoxis (hypoxidaceae) consist of about 90 species reported worldwide, of which 76 occur in Africa. As many as 41 species are indigenous to countries belonging to the Southern African Development Community (SADC), including South Africa. Of all the hypoxis species, H. hemerocallidea has versatile application in traditional health care system of over 85% of South Africans and is regarded as one of the most ethno-medicinally important and most marketed species in South Africa. H. hemerocallidea corms water extract is widely used as traditional medicine for the treatment of benign hypertrophy, urinary tract infections, boosting the immune system of people living with HIV-AIDS among others. However, the use of other part of hypoxis plant as medicine is vital for conservation purposes. The roots attached on the corm of H. hemerocallidea corm contain hypoxoside, but the roots are usually ripped off during the preparation of hypoxoside containing traditional medicines and other herbal products. A developed and validated affordable but reliable high performance thin layer chromatography (HPTLC) densitometry for the rapid and repeatable visualization and quantitative determination of hypoxoside from roots of H. hemerocallidea was determined. The hypoxoside was visualized at Rf of 0.30 in CHCl₃:MeOH:H 20 (v/v/v) using the method with a good linearity of 0.9565 over a calibration range 0.20-1.80 ng band^-1. The LOD and LOQ was 5.08 and 16.76 mg band^-1, respectively while the percentage recovery and the method repeatability (%RSD) was 84.10 and 4.98 were within limits regarded as acceptable for the analysis of plants and other botanicals. The roots contain 382.18 ng/band of hypoxoside

Biography:

Nurul Qamariah was born in Palangkaraya, Indonesia, in 1990. She received the B.E degree in Chemistry  Education from Palangkaraya University, Central Kalimantan, Indonesia, in 2011, and the M.Sc degree in Pharmacy Herbal Medicine from University of Indonesia, Indonesia, in 2014. In 2014 She joined Faculty of Health Science, Muhammadiyah University of Palangkaraya, as a Lecturer. Since 2015, she became Head of planning and database division of Muhammadiyah University of Palangkaraya. Her current research interests include herbal medicine, natural product, and ethnobotanical.

Abstract:

In Islam, ethical teachings of biomedical ethics are linked with Holy Qur`an and Prophet Muhammad (PBUH). Qur`an is the central religious text of Islam, which Muslims believe to be a revelation from God. The Quran is divided into chapters (surah in Arabic), which are then divided into verses (ayah). Qur`an mention a great number of wild plants that are still used in folk medicine. Qur`an  is one of the best reference books describing the importance of plants for medical benefits, where there are 28 Chapter (Surah) those mentioned specific name of plants in Al-Qur`an. This paper aims to compile the up-to-date information about some medicinal plants that mentioned in Al-Qur`an. Based on the collected data, there are 27 plant species mentioned in Al-Qur`an. In this paper, plants species were arranged in systematic order of identity of plant (The identity of the selected plants were confirmed from existing literature such as, books, journal article, and family and species of plants were confirmed from nomenclatural and bibliographic database), followed by Indonesian name, English name, Family, references cited from Holy Qur`an, part used, chemical constituents, and efficacy of herbal medicine that has been used both empirically and scientifically.

Biography:

Lei Gao has completed his Master’s degree of Medicine at Shandong University of Traditional Chinese Medicine, China in 2011. He was awarded the Eurasia-Pacific-Ernst Mach Scholarships in 2016 and is currently a PhD candidate

Abstract:

Cardiovascular disease is the top death cause in people with diabetes, particularly in individuals with elevated homo-cysteine (Hcy) level. Left ventricular hypertrophy and endothelial dysfunction are critical signs of heart disease and vascular disorder respectively in diabetics. Salvianic acid A (SAA) is a major active ingredient extracted from a typical traditional Chinese medicine applied in treatment of cardiovascular disease. In this study, we investigated the protective effects of SAA on left ventricular hypertrophy and endothelial dysfunction in db/db mice with elevated Hcy level and to decipher whether the cardio-protective effects of SAA involve the modulation of methylation potential and improvement of redox status in liver. Our results suggested that chronic administration of SAA suspended left ventricular hypertrophy within the intervention period (2.9% increase of left ventricular mass in SAA-treated group compared to 49.0% increase of left ventricular mass in group without treatment) and ameliorated endothelial dysfunction in db/db mice (improve endothelial-dependent vasorelaxation by 42.8% in SAA-treated group compared to group without SAA treatment). The acute vaso-relaxant effects of SAA were also assessed in ex vivo assay. Besides, the serum Hcy level in group with SAA treatment was found significantly decreased 40.8% compared to diabetes group without SAA. These observed cardio-protective effects of SAA are probably due to improved redox status induced by the antioxidant effect of SAA itself and to the increased production of glutathione (23.2% increase in SAA-treated group compared to group without SAA treatment) via up-regulation of trans-sulfuration pathway during the Hcy metabolism in liver

Biography:

Miss Sucharat Tungsukruthai has completed her Bachelor’s Degree in science (Biology) from Chulalongkorn University in 2016. After graduation, she has studied Master Degree in Pharmacology and she is a training researcher at Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand. She interest in special pathways in cancer such as apoptosis, metastasis, and autophagy

Abstract:

Lung cancer metastasis is one of the most common causes of cancer death. The process requires tumor cell dissemination, motility, intravasation, and formation of new tumor at different sites. Natural product-derived compounds exhibiting anti-motility effects is of interest as they may serve as promising lead compounds for cancer therapy. This research aimed to investigate the effect of cycloartobiloxanthone, a pure compound isolated from bark of Artocarpus gomezianus on migration and invasion activities of non-small cell lung cancer cells. Cells were treated with various concentrations of the compound to determine cell viability using MTT assay. The migration and invasion of the treated cells were evaluated by wound healing and transwell assays, respectively. Motility-related proteins were investigated by western blotting. Here we found that cycloartobiloxanthone exhibited potent anti-migration and anti-invasion activities tested in lung cancer H460 cells. In addition, results showed that the compound suppressed cell migration by attenuated migration regulatory proteins. Together, the inhibitory activity of cycloartobiloxanthone on lung cancer migration suggests that cycloartobiloxanthone may be suitable for further development for the treatment of cancer metastasis

Biography:

Alino Sumi is a PhD scholar of Martin Luther Christian University, Meghalaya, India in the department of Environment and Traditional Ecosystems. She has cleared the National Eligibility Test for both Junior Research Fellowship and Assistant Professorship. She is also the recipient of Martin Luther Christian University Merit Scholarship 2015

Abstract:

Ethomedicine is a study of the traditional medicine practiced by various ethnic groups, and especially by indigenous peoples. It deals with medicines derived from plants and use of different plant parts in the treatment of various diseases and ailments, based on indigenous pharmacopoeia, folklore and herbal charms. An extensive study on Ethnomedicinal plants of Sumi Nagas was conducted in four Sumi villages of Nagaland- Rotomi, Philimi, Khrimtomi and Askhomi. The survey deals with first hand information on medicinal plants used by the Sumi Nagas of Nagaland for catering to various health care regimes such as- rheumatism, bronchitis, hyperdipsia, dyspepsia, leucoderma, leprosy, scrofula, paralysis, etc . Detailed information regarding the medicinal plants, part(s) of the plants used and how they are used etc. were extracted consulting local health practitioners, elders and farmers. During the enumeration, all the plant species were arranged with their local name, distribution, family, medicinal system, part(s) used and the various uses for the treatment of diseases and ailments. Altogether, 50 (fifty) ethnomedicinal uses have been reported. Perhaps, this is the first hand investigation on medicinal plants among Sumi Nagas of Nagaland