3^rd Global Summit on Herbals and Traditional Medicine October 18-20, 2017 Osaka, Japan

Biography:

Younghee Yun has completed her PhD from college of Traditional Korean Medicine, Kyung Hee University, Seoul, Korea. From 2007 to June, 2017, she had worked as a clinical assistant professor of allergic/derma clinic of the Kyunghee University Korean medicine hospital at gangdong, conducted clinical studies in allergic skin diseases, and has published more than 12 papers. She is the CEO of CY Pharmaceutical Co., Ltd., a herbal medicine manufacturing and development company. Her main interest is atopic dermatitis, allergic skin disease and pharmacological action of herbal medicine.

Abstract:

Atopic dermatitis (AD) is a common pruritic inflammatory skin disease. In its chronic stage, hyperpigmentation, excoriation, lichenification, and dryness are the main symptoms. Jaungo comprises two herbs, Lithospermi radix and Angelica gigantis radix, and three carrier oils, and is an approved herbal ointment for xerosis in Korea. In past preclinical studies, we demonstrated that Jaungo had anti-inflammatory and anti-allergic activity. We conducted a randomised, double blind, placebo-controlled, single-centre trial with three parallel arms. Trial group 1 applies Jaungo twice a day, while trial group 2 applies Jaungo and the placebo once a day, separately, and the placebo group applies the placebo twice a day, for a total of 3 weeks each. Participants evaluated for eczema based on the Eczema Area and Severity score, the SCORing of Atopic Dermatitis Score, the Dermatology Life Quality score, transepidermal water loss, total IgE level, eosinophil count, and IL-17, IL-22, and IFN-γ levels. The outcomes to evaluate the safety included Draize score and blood test. In total, 28 patients (82.4%) completed the study. Significant decline of EASI scores in trial group 2 and placebo group was observed (p<0.05). There was significant decline of SCORAD scores in trial group 1 and placebo group (p<0.05). However, Patients in all groups showed decreased TEWL and DLQI scores with no significant difference. No clinically relevant changes in laboratory values were observed except IL-17. There was significant decline of IL-17 in all groups (p<0.05). Inter-group analysis showed no significant difference. No serious adverse event was observed.

Biography:

Jurairat Boonruab earned her Ph.D. from Chulalongkorn University, Thailand in 2015. She is currently Deputy Head of the Academic Affairs Department and a lecturer at the Faculty of Medicine of Thammasat University, Thailand. Her areas of specialization include applied Thai traditional medicine, alternative medicine, and public health science. She has published Thai massage and Heber medicine.

Abstract:

Myofascial pain syndrome (MPS) is one of the most prevalent illnesses among those in the working age group caused by poor ergonomics, especially remaining in a sitting posture for an extended period of time. One alternative treatment for MPS is the application of a hot herbal compress, which helps to improve the quality of life of patients and reduce the undesirable side effects of pain relief medication. A controlled trial was conducted in which 90 participants were randomized into the hot herbal compress group (n=30), the hot compress group (n=30), and the topical diclofenac group (n=30). The first two groups received a 20-minute hot herbal compress and hot compress treatment not exceeding the temperature of 40 °C once a week for two weeks, whereas the last was administered 2 mg of a topical diclofenac gel three times a day for two weeks. Before and after the treatment, their level of pain intensity and quality of life was assessed using a visual analog scale (VAS) and the 36-Item Short Form Health Survey (SF-36), respectively. Additionally, their cervical range of motion (CROM) and pressure pain threshold (PPT) were also evaluated. It was found that all the three groups experienced a statistically significant decrease in the level of pain intensity (p<0.05), a statistically significant increase in CROM (p<0.05), a statistically significant increase in PPT (p<0.05), and a statistically significant improvement in the quality of life (p<0.05). However, for the last two assessment criteria, the results for the hot herbal compress group and the hot compress group were not only relatively equal but also better than those for the topical diclofenac group.

Biography:

Capt. Dr. Chaiwat Thepsena,RTN has completed MD at the age of 24 years from Faculty of Medicine, Chulalongkorn University, furthered his studies acupuncture and moxibustion from Shanghai, M.S.c.(medical epidemiology) and also studied about neural therapy.  He practices for CAM (Complementary and Alternative Medicine) nineteen years at Somdech Phra Pinklao Hospital, Naval Medical Deparment.

Abstract:

Qing Kai Ling is known for neuro protective effect by relieving the damage of vascular endothelial cell as well as inhibiting the process of inflammation and also increases expression of endothelial nitric oxide syntheses. Clear body heat and detoxification is another benefit effect from Qing Kai Ling. During 10 years of usage this injection among 25,000 patients of coronary heart decease, cerebrovascular decease, chronic renal failure, respiratory tract infection, and cancer patients. The results appear so fantastic. Most of the patients become better after being treated. Coronary Artery Stenosis and Cerebral Artery thrombosis patients have evaluated by CT scan which show disappear of occlusion. Only four patients become worse with hypotension but recovery after using moxibustion.

Biography:

Kusuma Sriyakul   completed her PhD (Thai traditional and Alternative Medicine) in 2012 at  Chulalongkorn University Thailand. She is the lecturer at Chulabhorn International College of Medicine, Thammasat University Thailand. She has published several papers about herbal medicine in dysmenorrheal, Thai traditional formula.

Abstract:

Yanang Daeng (Bauhinia strychnifolia Craib.) was used for a treatment of poisoning, elimination of pesticides, an effect of poisonous mushrooms, poisoning, breast  milk stimulation in women after delivery and reduce fatigue, the study aimed to gather the knowledge and experience from the folk healers about the usage of Yanang Daeng. This study was conducted using in-depth interview and group discussions from folk healers in four sectors throughout Thailand. The results showed those 59 folk healers from 4 sectors which consisted of 67.80% male and 32.20% female. Furthermore, the age of the participants was studied and the results showed that they aged ranged among 61-80, 41-60, 20-40 and more than 81 years old which respectively accounted for 49.15%, 30.51%, 13.56% and 6.78%. For the treatment of patients who receive the toxins, some folk healers will grind the root with water or water from washing rice, then the patient will be immediately received a single dose portion of 2 tablespoons, but the others will boil the leave and stems and give the patient a single dose portion range from ½ to 1 glass. In emergency case, they will use 10 fresh leaves, then squeeze with water or water from washing rice, and immediately give to patient as a potion. Moreover, the folk healers recommended to the villager that they should use leaves rather than using vine or root to prevent the extinction and also suggested them to plant for convenient use. Yanang Daeng is potent in solving the urgent poisoning problem in the community before receiving further treatment.

Biography:

Dr Ray Cooper was born in the UK, received his Ph.D. in organic chemistry and after 15 years in R&D in the pharmaceutical industry, he moved to the dietary supplements industry. He developed new Chinese botanicals as supplements including Cholestin, Cordymax and Te-Green.

Currently Ray is visiting professor and lecturer at the HK Polytechnic University and co-founder of PhytoScience LLC, a consulting company creating innovative botanical solutions and products.

He is the recipient of the 2014 American. Society Pharmacognosy Tyler Prize for his life time contributions to Botanical Research. He is also a Fellow of the Royal Chemical Society, UK.

Ray has recently published three books:  Natural Products Chemistry: Sources, Separations and Structures (CRC PRESS) and Botanical Miracles, Plants that Changed the World, and Chinese and Botanical Medicines. He has edited 5 books, most recently, Botanical Medicine: from Bench to Bedside and published over 100 peer reviewed scientific articles.

Abstract:

With the gluten-free food market worth almost $3.6bn in 2016, there is every reason for renewed interest in ancient grains. This resurgent interest is expressed in re-discovering ancient varieties as functional foods. In particular, people affected by celiac disease have to avoid all gluten in their diet and several ancient grains may offer an important alternative.

Ancient grains include chia, a forgotten food of the ancient Aztecs; quinoa which originated in the Andean region of Ecuador, Bolivia, Colombia and Peru; triticum (wheat), in the form of einkorn, known today as farro in Italy, as a type of awned wheat and one of the first crops domesticated in the Near East. Other grains, acknowledged as gluten-free ancient grains are amaranth, eaten in Mexico since the time of the Aztecs; quinoa, sorghum, millet; and teff, the main ingredient in the stable fermented flatbread, injera, in Ethiopia. A description of modern wheat is presented together with each one of the above mentioned grains-

Biography:

Wilfred Mabusela completed his PhD at the University of Cape Town, South Africa, and this was followed by two years of postdoctoral studies at the same institution, which extended his doctoral work on structural studies of plant polysaccharides. He subsequently took up a lecturing position at the University of the Western Cape where he is currently an associate professor. He has published more than 30 papers in reputable journals, and has been a visiting scientist at institutions in Europe and North America.

Abstract:

Traditional medicine is a cultural practice with a long history in Africa, and in South Africa it involves the use of approximately 3000 plants, out of a national biodiversity represented by about 30 000 higher plant species. For most of these, there is very little information about their phytochemical constituents, given that the therapeutic value of these plans is known to reside in their phytochemical composition. Furthermore, for most of these plants, some of which are on the open market, there are still no strict quality control reference data, which verifies the phytochemical profile of a particular plant sample. Hence the purpose of this study is broaden the knowledge on the phytochemical composition of medicinal plants, information which is expected to facilitate an understanding of their mode of action, in terms of therapy and toxicity. Methodology: Some medicinal plant species from South Africa and other African countries were collected.  Dried material samples were subjected to extraction using water as well as a variety of organic solvents followed by chromatographic fractionation of the extracts obtained. Isolated compounds were examined for their chemical structural features with the aid of nuclear magnetic resonance and mass spectroscopy. Some of the crude extracts and purified compounds were also studied for biological activity such as antioxidant activity, cytotoxicity (using the brine shrimp lethality bioassay), for antimicrobial activity against gram-negative and gram positive bacteria as well as fungal species, and enzyme inhibition properties. Findings:  Spectroscopic studies led to the identification of compounds belonging to the following classes: flavonoids and, terpenoid- and flavonoid- glycosides. Some extracts and isolated compounds displayed a broad spectrum of biological activities.

Biography:

Dr Tshikalange is a senior Lecturer in the Department of Plant and Soil Sciences of the University of Pretoria, South Africa. His research focus areas include ethno-botanical medicinal plants used traditionally in the treatment of sexually transmitted diseases, oral pathogens and antimicrobial activities. He has published articles in peer reviewed national and international journals, such as the South African Journal of Botany and Journal of Ethnopharmacology and has been serving as an editorial board member of BMC Complementary and Alternative Medicine. He co-authored chapters in the book Medicinal plant research in Africa: pharmacology and chemistry. Several postgraduate students have completed their studies under his supervision.

Abstract:

Sexually transmitted diseases have a major impact on sexual and reproductive health worldwide. Each year, the World Health Organization estimates 448 million new cases of curable STD’s are diagnosed. Ethanol extracts of twelve South African medicinal plants used in the treatment of STD’s and 3 flavonoids were investigated for their antimicrobial activity against Candida albicans, Gardnerella vaginalis, Neisseria gonorrhoeae and Oligella ureolytica. The anti-inflammatory activities of the extracts and compounds were determined by measuring the inhibitory effect of the extracts and compounds on the pro-inflammatory enzyme lipoxygenase. The extracts and compounds were also investigated for their anti-HIV activities against recombinant HIV-1 enzyme using non-radioactive HIV-RT colorimetric assay. Acacia karroo and Rhoicissus tridentata extracts showed good antimicrobial activity with MIC values ranging between 0.4 and 3.1 mg/ml. Extracts of Jasminum fluminense, Solanum tomentosum and flavonoids 2 and 3 had good anti-inflammatory activity with IC₅₀ less than the positive control, quercetin (IC₅₀ = 48.86 ug/ml). A. karroo and flavonoid 3 exhibited moderate HIV-1 RT inhibition activity of 66.8 and 63.7 % respectively. R. tridentata and Terminalia sericea had the best RT inhibition activity (75.7 and 100 %) compared to that of the positive control doxorubicin (96.5%) at 100 ug/ml concentration. The emergence of drug resistance in STD related microorganisms and potential side effects demand the discovery of newer drugs. The exploration of newer anti-microbial substances from natural sources may serve as promising alternatives. The observed activities may lead to new multi-target drugs against sexually transmitted diseases.

Biography:

Dr. Hsieh has complete the Chinese Medicine Doctor scholarship from China Medical University in Taiwan. He is serving as a Chief Resident Doctor of Chinese Medicine in Department of Chinese Medicine, Taipei Tzu Chi Hospital. He has intensively study in ShangHanLun and the Pulse Diagnosis of Traditional Chinese Medicine.

Abstract:

Introduction

Generally, western medicine treat patients with insomnia disorder in inhibiting or releasing way. But in the concept of Yin-Yang in Traditional Chinese Medicine(TCM), it’s not always effective to the Yang Deficiency patients, especially the Heart Yang Deficiency ones. We consider that being frightened could leads to Heart Yang Deficiency and Spirit-Restless Pattern in TCM.

Material and Methods

This case is a 64-year-old woman, suffered from domestic violence intermittently in 2015 and then divorced. After that, insomnia disorder, palpitation, empty feeling in chest, panic and anxiety was noted. Also, she dreamed about being hit accompanied with somniloquy and waving arms every night for about a year. There’s also weak pulse in cun position of both wrist pulse. Those symptoms and pulse findings are the same features as the Heart Yang Deficiency. Therefore, we treated her by warming Heart Yang and settling the Spirit formula (extract powder of Guizhi-Gancao-Longgu-Muli Decoction桂枝甘草龍骨牡蠣湯) 2.6gm four times a day since 2017/1/5.

Result

After the first week receiving the formula, there’s still dreamful sleep, but the palpitation partially relieved. After the second week, dream alleviated with only somniloquy left. Palpitation, empty feeling in chest and panic also relieved obviously. There was no significant side effect during or after the treatment.

Conclusion

We suggest that warm Heart Yang and settling the Spirit formula (Guizhi-Gancao-Longgu-Muli Decoction桂枝甘草龍骨牡蠣湯) is an effective and safe treatment for the Heart Yang Deficiency patients.

Biography:

Dr. Mohammad Zashim Uddin obtained His B.Sc. (Hons.) and M. Sc. (Thesis) Degrees in Botany from the University of Dhaka. Later He awarded with Ph. D. degree at the age of 32 years from the same University. Dr. Zashim trained from USA on tropical biodiversity conservation and research proposal development.  His current position is Professor in the Department of Botany, University of Dhaka and supervised 29 MS research students and presently guiding one Ph D student and three MS students. By this time, He published 63 research articles/books/book parts in different national and international scientific journals

Abstract:

The present article focuses the consensus of local people of Brahmanbaria district in the use of ethnomedicinal plants to treat different ailments in their daily life. Data on medicinal use of plants were collected in between June 2015 to June 2016 from 459 local people using mainly modern ethnobotany survey techniques. A total of 208 medicinal plants under 83 families were recorded. Such plants are used to treat 73 ailments through 407 formularies. The most commonly used medicinal plants are Centella asiatica, Litsea glutinosa, Coccinea cordifolia, Azadirachta indica, Cynodon dactylon, Ocimum sanctum, and Leucus lavandulifolia. Among the ailments categories high informant consensus factor (Fic) was found in case of diarrhoea and dysentery followed by kidney disorder, respiratory tract disorder, gynecological, fever and pain, dermatological, helminthiasis, skeletomuscular pain, diabetes and liver disorder, gastrointestinal, cardiovascular, jaundice, mental, impotence, teeth ache and ophthalmological. Most cited species for the treatment of such ailment categories are Litsea glutinosa, Holarrhena antidysenterica, Kalanchoe pinnata, Ocimum sanctum, Abroma augusta, Alternanthera sessilis, Azadirachta indica, Ananas sativus, Achyranthes aspera, Coccinia cordifolia, Andrographis paniculata, Hyptis sauveolens, Terminalia arjuna, Eclipta alba, Cajanas cajan, Asparagus racemosus, Kalanchoe serrata, and Commelina benghalensis. Among medicinal plants, Centella asiatica, Adhatoda vasica, Clerodendrum viscosum, Clitoria ternatea, Tinospora crispa, Dalbergia sissoo, Ficus benghalensis, Ficus hispida, Holarrhena antidysenterica,  Paederiea foetida,  Scoparia dulcis and Thevetia peruviana were showed 100% Fidelity level (Fl) values. Plant species with high citation, Fic and Fl values can be subjected to further ethnopharmacology studies to find active compounds for the new drug candidates

Biography:

Christopher T. Arick, DC, MS is currently the Assistant Dean and Chief Acacdemic Officer of Chiropractic Medicine at the National University of Health Sciences. He has completed his Doctor of Chiropractic degree at National University of Health Sciences in 2005 and has earned a master’s degree in advanced clinical practice. Dr Arick has taught for the university for since 2012. He is currently pursuing a PhD in Higher Education Administration from the University of South Florida where his research topic is integrative medicine education.

Abstract:

The purpose of this case report was to describe the examination and management of a patient with chronic fatigue. A 34-year-old woman presented to a chiropractic clinic with complaints of fatigue and inability to lose weight for 2 years. When tested, she was found to have high serum thyroglobulin antibodies, low serum vitamin D3, low saliva dehydroepiandrosterone-sulfate, and low saliva total and diurnal cortisol. The patient was placed on an anti-inflammatory ancestral diet and given recommendations to decrease the aerobic intensity of her exercise routine. On the basis of the result of conventional and functional laboratory tests, she was prescribed a treatment plan of targeted supplementation. After 12 weeks of application of dietary, lifestyle, and supplementation recommendations, the patient reported experiencing increased energy and weight loss of 15 pounds. Her thyroglobulin antibodies returned within reference range, salivary cortisol increased and closely followed the proper circadian rhythm, and dehydroepiandrosterone-sulfate increased. This report describes improvement in a patient with chronic fatigue with the use of nonpharmaceutical polytherapy involving dietary changes, lifestyle modification, and supplementation.

Biography:

Karin Kraft is qualified in internal medicine and naturopathy, and holds the chair of naturopathy at the University Medicine of Rostock, Germany since 2002. She has published more than 140 papers in reputed journals and is president of the German Society on Phytotherapy since 2010.

Abstract:

In Europe, herbal medicinal drugs (HMPs), and food, including food supplements, have different legal definitions (Directive 2001/83/EC and Regulation 1924/2006, respectively). They therefore must be clearly separated. HMPs have pharmacological effects and are used for therapy, relief, prevention or diagnosis of diseases. They are subdivided into HMPs with the status well-established use (proven efficacy by at least one sufficient clinical study, proven quality and tolerability, and indications for mainly mild diseases), and HMPs with the status traditional use (proven quality and tolerability, and indications for minor health problems). On the contrary, foods and food supplements have physiological effects and are primarily used for nutrition or health-related effects by healthy consumers. There is no commitment to control for their quality and tolerability, and they are promoted by a health claim. In the EU, food supplements produced from plants and their preparations (“botanicals”) until now very often have unapproved health claims reminding of the indication of HMPs with traditional use status. However, consumers have to be informed correctly on the nutrition and health value of plants and their preparations contained in food and food supplements in order to be able to choose the appropriate product for their needs. Hence, all health claims should be based on relevant health-related effects that have been proven by adequate scientific evaluation.

Biography:

Poet, Psychiatrist and Psychotherapist, Bihabwa worked as a psychiatrist for four years in the eastern Democratic Republic of Congo. Among other things, he treated women who had been raped and their children, from rape. He was the coordinating doctor of the National Program of Mental Health in the province of South Kivu. He worked at the Fann hospital in Dakar for three years before going to France at the EPSM des Flandres.Psychiatrist, he specialized in Transcultural approach at the University Paris Descartes, in the program coordinated by Professor Marie-Rose Moro.His research explores the problem posed by traumatic events on social and societal dynamics. He works on the trauma and resilience of children from rape in a patrilineal patriarchal society. He is particularly interested in topics related to the transmission of trauma and Transgenerational trauma.In the treatment, he works on the complementary approach, which combines traditional and modern approaches.

Abstract:

Introduction

To have studied, worked and earned his salary constituted a transgression against the will of the deceased father. To be purified, a special course was necessary: healers-exorcists-hospital.
The individual experience of illness exhumed, in B, conflicts between transmissions, filiations and affiliations.
It is the relation to knowledge in a universe where it draws from two sources, made heterogeneous.

Results

M'B grew up in the royal court, emblematic symbol of the pure tradition. Graduated as nurse, he was hired by the Congolese organization of emergency management, Croix-Rouge du Congo. As head of an aid worker team, M Bami is led to deal with disasters, especially those produced by the exactions of armed groups given the current state of the security context in eastern DRC.

In the middle of a mission, to intervene in a slaughter in which was killed thirty-eight people, a psychic trauma was triggered in him.

Alongside the literary descriptions ―learned in school and used every day for his patients― the reading of his own suffering is traditional first. M Bami has managed to subtly carry his illness within an area where mix Western type treatment and traditional type. This disease was, in addition, an opportunity for rereading family ties, relationships between his ―very demanding― work and his father’s will. The king's witch doctor, the same who treated his father, provided the key, by his ritual to soothe family disputes. He also updated the meaning of symbols in order to establish individual and collective narrative identity, so that M B's work is no longer in conflict with his deceased father's will.

Conclusion

The value of this case lies in the reflection on modernity in the health system to provide mediation between two intentionally made heterogeneous universes: the theories of some against realities of living of others. Caregiver training, while remaining scientist would benefit from being closer to cultural practices to finally aspire to its note of nobility: become more Humans.

Biography:

Daniela M. A. F. Navarro has completed his PhD at the age of 27 years from University of São Paulo (USP) and postdoctoral studies from Federal University of Alagoas (Brazil)/IACR-Rothamsted, U.K.. She has published more than 60 papers in reputed journals and has been serving as referee of reputed journals.

Abstract:

Aedes aegypti is vector of Dengue and Yellow Fevers, a mosquito of public health importance. It is the most broadly disseminated urban species of mosquito in the world. Larval insecticide is one of the alternatives to control the mosquito dissemination. Temephos and Bacillus turinghiensis subsp. israelensis (Bti) are the larvicidal most used in the world to combat A. aegypti mosquito. In face of larvae resistance to Temephos and the high cost of Bti production in large scale, research programs on insecticides often focus on alternative compounds and natural products as rich sources of larvicides. Repelletn and oviposition deterrent are used to reduce the contact between infected mosquito and urban population. In this work we describe significant larvicidal, repellent and oviposition deterrent activities research of essential oils against A. aegypti. Some larvicidal acitivity of plants and seweed will described.

Biography:

Xin Zhou has completed her PhD at the age of 42 years from West China school of pharmacy, sichuan university. She is the director of Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, a premier herbal medicine quality control service organization. She has published more than 150 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract:

A sensitive, reliable and accurate HPLC-MS-MS method was developed and validated for the quantification of Gallic Acid (GA) and Protocatechuic Acid (PCA) in rat plasma, tissue and excretion. A single-step protein precipitation by acidic acetonitrile was used to prepare samples. GA, PCA and bergenin (internal standard, IS) were separated by using a C₁₈ column and a mobile phase consisted of acetonitrile and water containing 0.1% formic acid running at a flow rate of 0.2 ml/min for 10 min. Detection and quantification were performed using a mass spectrometer by the multiple-reaction monitoring (MRM) in positive electrospray ionization mode. The optimized mass transition ion pairs (m/z) for quantitation were [M+H] 169.181 →125.268 (GA)、152.918 → 109.244 (PCA) and 326.922 → 192.167 (IS) , respectively. After oral administration of 0.36, 1.08 and 2.16 g·kg^-1 of Polygonum capitatum extract, respective values of pharmacokinetic parameters for GA and PCA were: t_1/2 1128.52/42.81、93.72/90.15and 114.70/49.80min; C_max 245.98/11.90, 477.20/24.66, and 805.76/31.04 ng·ml^-1. Linear pharmacokinetics was established based on high correlation coefficients (γ > 0.90) of pharmacokinetic parameters. The results of tissue distribution showed that GA mainly distributed in kidney, lung, and liver, while PCA mainly distributed in kidnry and lung. Less than 23.08% and 19.39% prototype of GA and PCA , respectively, were excreted from urine and feces path indicating that GA and PCA are extensively metabolized in rat.

Biography:

Dr. Mohammad Kamil a Chartered Chemist and  Fellow of Royal Society of Chemistry London   is Head TCAM Research Section, Zayed Complex for Herbal Research & Trad.Medicine, Regulation Division ,Health Authority –Abu Dhabi,UAE  .Recipient of Common Wealth Award-London; Convention Award of Chemical Society-India; Academic Exchange Fellowship from Association of Common Wealth Universities -London; and Global award on Unani Medicine and various other prestigious honors &  awards. Worked as in charge of Drug lab.MoH India, Professor at Jamia Hamdard University, Produced 6 Ph.Ds and 14 M.Phil. Students . More than 325 papers and abstracts in reputed journals and international conferences are at credit; chaired a no. of scientific sessions and presented invited talks as plenary and invited speaker at various International conferences / symposia.  Associated with publication of many books; Author of a book and five chapters in different books; Research work cited widely in books e.g. Advance in research, Chapman and Hall, London.

Abstract:

The challenges are innumerable and enormous, making the global herbal/botanical market unsafe. The talk seeks to enlighten physicians, pharmacists, consumers and stakeholders in botanical medicine on the need to establish quality parameters for collection, handling, processing, manufacturing and production of safe botanicals as well as employ such parameters in ensuring the safety of the global botanical market which is directly linked to the safety of public health.

In the recent years with ever growing commercialization in the field of herbal medicines, there has been an instant demand for quality control of the drugs used in this system. The studies on the identity, purity and quality of the genuine drug will enhance information in checking the adulteration. A set of standards would not doubt be detterent on substitution and adulteration and also an aid for ‘Drug law Enforcement’.

In the present paper an attempt has been made for a sequential  study of the Quality Control of Herbal Medicinal Products ( HMP ) starting from Selection of Medicinal Plants ;Good Agricultural Practices (GAP ) Cultivation ;Good Field Collection Practices(GFCP) ; Organized and Unorganized Drugs ;Source and Period of Collection; Identification; Storage  ; Chemical Standardisation ; Assay ; Good Manufacturing Practices (GMP) and Pharmacological studies to Clinical Approach , with special reference to maintain Standardisation at each and every stage.Adulteration of  unlabled ingredients/hidden ingrediets will be discussed with practical laboratory  experience.

Biography:

Will be updated soon

Abstract:

Microtubule-associated protein light chain 3-II (LC3-II), and Sequestosome-1 (SQSTM1) are proteins that can be used as markers for autophagic pathway. Bcl-2 is a protein that is reported to be inversely correlated with apoptosis. We aimed to investigate the effects of curcumin on liver inflammation and fibrosis up to the first dysplastic stage of Hepatocellular carcinoma (HCC) induced by Thioacetamide (TAA) in rats and clarified the effects of curcumin on LC3-II, SQSTM1, and Bcl-2.

Male Sprague-Dawley rats were randomized into 4 groups: Control group and 3 groups received TAA 200 mg/kg i.p. twice weekly for 18 weeks: TAA group, Curcumin low-dose group, Curcumin high-dose group. Oxidative stress markers as hepatic malondialdehyde (MDA) concentration and superoxide dismutase (SOD) activity were measured by colorimetric methods. Hepatic SQSTM1 concentration was measured by ELISA, and gene expression levels of Bcl-2, and LC3-II was measured by RT-PCR. We also investigated the In vitro effect of curcumin on HepG2 cells viability through MTT assay, and the involvement of autophagy in this effect.

Curcumin increased the survival percent in rats, decreased α-fetoprotein (AFP) concentration, and serum aspartate aminotransferase (AST) activity, and increased serum albumin concentration. Curcumin also caused a significant reduction in oxidative stress in liver, inhibited apoptosis, and induced autophagy. In vitro, It was found that curcumin decreased HepG2 cells viability and the concentration of SQSTM1.

In conclusion, curcumin leads to protection against TAA induced HCC through activating autophagic pathway and inhibiting apoptosis. Also, The antioxidant activity of curcumin almost prevents liver fibrosis.

Biography:

Dasril BASIR  has completed his Chemistry Bachelor at  Andalas University  in 1984 and Master in Organic Chemistry at The Institute of Technology Bandung, Indonesia  in 1986.  One year research  of Intership of Organic Synthesis at School of Chemistry, UNSW, Sydney, Australia in 1989. The Six Months Joint Research on RGD Peptidemimetics at Department of  Pharmaceutical Chemisry, The University of Kansas, Lawrence, USA in 1995 and Six Months Researc visit of Natural Products Chemistry and  Biologycal Activity  at Institut Fur Pharmazeutische Biologie,  Heinrich Heine  Universitat , Dusseldorf,  Germany in 2002. He has three sccopus published articles dealing with phytochemistry works on Fragraea fragrans fruits  and two DOAJ published articles.

Abstract:

Fragraea fragrans fruits are locally named buah tembesu, belongs to Loganiaceae family. Those can be harvested two time a year, in May and in November. The major secondary methabolites of the fruits are ursolic acid and its isomer oleanolic acids (3.1% accounted from the dried ones). In order to develop these fruits become topical herbal cosmetic products for skincare. The bioactive compounds of the fruits have been mapped to consider their side effects as well as their  efficacy. Eleven compounds have been successfully identified with LCMS/MS from the filtrates of the methanol extracts of the fruits after the solid crystals of ursolic acid and its isomer oleanolic acid  have completely precipitated^[1,2], and their chemical structures were confirmed by comparing their molecular ion peaks to relevant compounds in some of references respectively; including the fragment ion peaks patterns.  As a result, those compounds were clasified into phenyl propanoic, pentacylic triterpene acids, flavones, phenyl propanoic, and tanin trimer groups.

Biography:

Susy Tjahjani is a PhD.and works as a lecturer and a chairman of Tropical Disease Research, Medical Research Centre in Faculty of Medicine, Maranatha Christian University.

Abstract:

In order to overcome malarial resistance tendency against ACT (artemisinin based combination therapy), several galenic preparations of Garcinia mangostana L rind have been studied and they have antimalarial activity in vitro. One of the major xanthones in this rind may contribute to this activity. Curcumin as one of the major compound of Curcuma domestica, is also potentially to have antimalarial activity. The aim of this study was to evaluate the antimalarial activity of this xanthone, curcumin, and one derivate of artemisinins and also to evaluate their mechanism of action. Interaction between them each other as antimalarial in vitro was also studied. Antimalarial activity was studied in in vitro 3D7 Plasmodium falciparum cultivation incubated with these compounds to look for the IC50 and ∑FIC50 of them. The mechanism of action of these compounds was observed electron microscopically. The result of this promising study would be reported.  

Biography:

Dr. V. Veena is currently working as Assistant Professor at School of Chemical and Biological Sciences, REVA University, Bangalore, India. Dr. Veena did her doctoral studies from Pondicherry University, India in 2016 and has 8 years of Research experiences and one year of teaching experience for post graduate and graduate students. Her area of Research includes small molecules of diverse origin for cancer therapy and nanophotosensitisers for photodynamic therapy. She is recipient of junior and senior research fellow from Council for Scientific and Industrial Research (CSIR) and University Grant Commission (UGC), Government of India. She was also awarded Research Project Assistant in UGC-SAP (special assistant program) by Department of Biotechnology, Pondicherry University, India. Her research contributions was published peer reviewed international journals and she is reviewer of some journals.

Abstract:

Statement of the Problem: Several herbal and ayurvedic preparations are currently used to treat the cancer patients. Although, several herbs used in such treatment contains pharmacologically important molecules but they are yet to be identified and their mode of action is not studied in detail. Cancer is defined as a wound that never heals due to its complicated cellular organizations. Thus, the main objective of present investigation was to identify the herbal leads that target the inflammatory tumor environment through modern approaches.

The purpose of this study: India is the major country that is rich in the biodiverse compounds to treat disorders through herbal and ayurvedic approaches. Several natural lead molecules are being reported and continuously being investigated globally. The good examples are being curcumin and taxol derivatives of natural origin that is effective against cancer and inflammatory disorders. Identification of small molecule drugs from herbs by increasing the selectivity towards tumor is the prime importance of the study. In this context, we have investigated several diverse herbal lead molecules that aimed to increase the selectivity and inflammatory aspects of heterogenic cancer components.

Methodology and Theoretical Orientation: The major photochemical components of herbs used in treatment of various disorders was screened to identify an active components based on preliminary studies. Further, through virtual screening, the compounds were identified against cancer specific targets by computational approaches. The results were validation by in vitro interaction studies and cell-based approaches followed by in vivo toxicity studies.

Findings:The lead molecules were obtained that can be used for in vivo studies for development of anticancer drugs. The findings also enriched the knowledge regarding mechanistic approach of ayurvedic drugs being used.

Conclusion and Significance: The active herbal constituents that target the multiple pathways which are deregulated in cancer was very useful to for identification of some pharmacologically important lead backbone that cannot be obtained by cheminformatic approaches andfurther utilized for clinical trials. This study identified the synergistic components of leads and other vital components present in the herbs increased the selectively towards cancer. This study also enriched the knowledge regarding the mechanism of action of some Indian ayurvedic herbal preparations.

Biography:

Faezeh Dadras has her experience in relationship between traditional medicine and architecture. She has worked on effects of temperament as traditional medicine grouping for human on their tendency to different environment factors. She has reached to this relationship after several experiments on human temperament and their trend to various environment factors like (color, light, material, temperature, etc.) in traditional medicine clinics. According to quick change of time and stability of propensities and general mental and physical needs of human, it is necessary for environment designers to become familiar with temperamental principles that include physical and spiritual conditions of users of spaces.

Abstract:

People with various mental and physical features show different favorites to colors. The relationship between individual features of humans and their propensities to circumstantiality of color have been evaluated in psychological discussions. According to generality of concept of temperament and covering physical and mental features of people, it seems that a significant relationship can be obtained between temperamental difference of people and their propensities to circumstantiality of color. Temperaments of 100 visitors to traditional medicine clinic at Tehran University were identified by method of doctor checkup and temperament-assessment questionnaire. Their propensities to three components of coldness and warmth of colors, light and darkness of color and contrast or uniformity in the arrangement of colors next to each other in both fields of colors selection and spaces selection with different tonality were obtained by questionnaire of assessment of temperament. Totally 100 responders with age average of 27 years old with gender of 42% male and 57% female completed the questionnaire. Wet temperaments have more propensity to light colors and also spaces with light tonality than the dry temperaments. Warm temperaments have more interest to warm colors than the cold temperaments but they prefer spaces with cold tonality. There was no significant relationship between temperamental groups and propensity to spaces with arrangement of harmonious or opposite colors beside each other. There is a significant relationship between temperamental differences of people and their propensity to circumstantiality of color. Wetness or dryness of temperament is effective on circumstantiality of lightness and darkness of color and warmth and coldness of temperament is effective on propensity to warmth and coldness of the color. Attention to temperamental propensities of people in propensity to colors can improve quality of human made physical environment and create human-based and health center space.