Sucharat Tungsukruthai
Chulalongkorn University, Thailand
Title: Cycloartobiloxanthone, extracted from bark of Artocarpus gomezianus, inhibits the migratory behavior of non-small cell lung cancer cells
Biography
Biography: Sucharat Tungsukruthai
Abstract
Lung cancer metastasis is one of the most common causes of cancer death. The process requires tumor cell dissemination, motility, intravasation, and formation of new tumor at different sites. Natural product-derived compounds exhibiting anti-motility effects is of interest as they may serve as promising lead compounds for cancer therapy. This research aimed to investigate the effect of cycloartobiloxanthone, a pure compound isolated from bark of Artocarpus gomezianus on migration and invasion activities of non-small cell lung cancer cells. Cells were treated with various concentrations of the compound to determine cell viability using MTT assay. The migration and invasion of the treated cells were evaluated by wound healing and transwell assays, respectively. Motility-related proteins were investigated by western blotting. Here we found that cycloartobiloxanthone exhibited potent anti-migration and anti-invasion activities tested in lung cancer H460 cells. In addition, results showed that the compound suppressed cell migration by attenuated migration regulatory proteins. Together, the inhibitory activity of cycloartobiloxanthone on lung cancer migration suggests that cycloartobiloxanthone may be suitable for further development for the treatment of cancer metastasis