Day 3 :
- Track: 2 Traditional Medicine | Track; 6 Medicinal Plants
Session Introduction
Bapela Johanna
University of Pretoria, South Africa
Title: Bioprospecting South African medicinal plants for antiprotozoal lead compounds
Time : 09:30-09:55
Biography:
Dr Johanna Bapela is a full time permanent lecturer at the Department of Plant and Soil Sciences of the University of Pretoria, South Africa. Her research area is mainly focussed on bioprospecting indigenous plant species for antiprotozoal chemotherapeutic agents. She is an affiliate of University of Pretoria Institute For Sustainable Malaria Control (UP ISMC) and Medical Research Council Collaborating Centre for Malaria Research, which collectively coordinate and promote collaborative research on safer and sustainable malaria control and management strategies, and to generate new knowledge and support new activities pertaining to safe malaria control in Africa
Abstract:
Vector-borne infectious diseases remain the main public health problem affecting many people in tropical and subtropical regions. Chemotherapy is still one of the fundamental measures used in the control and treatment of protozoal diseases; however, the emergence of resistant strains is compromising its effectiveness. The main aim of this study was to bioprospect South African indigenous plant species for novel antiprotozoal plant products. Twenty plant species were collected, extracted in dichloromethane: 50% methanol (1:1) and then separated into polar and non-polar fractions. The acquired crude extracts were tested on Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani and Plasmodium falciparum. The current study is the first scientific account on the significant antileishmanial efficacy (IC50 ≤ 5 µg/ml) of Bridelia mollis, Vangueria infausta subsp. infausta, Syzygium cordatum and Xylopia parviflora, as well as high antitrypanosomal activity of Albizia versicolor. Ten plant extracts exhibited significant in vitro antiplasmodial activity, with Tabernaemontana elegans and V. infausta subsp. infausta being the best samples. Application of supervised Orthogonal Projections to Latent Structures–Discriminant Analysis (OPLS-DA) on the 1H NMR profiles resulted in a discrimination pattern that could be correlated to the observed antimalarial bioactivity. Further phytochemical analyses let to the isolation of dregamine and tabernaemontanine from T. elegans as well as friedelin and morindolide from V. infausta subsp. infausta. The study demonstrated the potential of discovering novel antiprotozoal scaffolds from medicinal plants
Kokoette Bassey
Sefako Makgatho Health Sciences University, South Africa
Title: Quantification of herbal drug hypoxoside from the roots of South African Hypoxis hemerocallidea using cost effective HPTLC-densitometry validated method
Time : 09:55-10:20
Biography:
Kokoette Bassey has completed his PhD from Tshwane University of Technology and is currently a Senior Lecturer at Sefako Makgatho Health Sciences University. He has published 3 papers in reputed journals and has reviewed twice for the South African Journal of Ethnopharmacology
Abstract:
Hypoxis (hypoxidaceae) consist of about 90 species reported worldwide, of which 76 occur in Africa. As many as 41 species are indigenous to countries belonging to the Southern African Development Community (SADC), including South Africa. Of all the hypoxis species, H. hemerocallidea has versatile application in traditional health care system of over 85% of South Africans and is regarded as one of the most ethno-medicinally important and most marketed species in South Africa. H. hemerocallidea corms water extract is widely used as traditional medicine for the treatment of benign hypertrophy, urinary tract infections, boosting the immune system of people living with HIV-AIDS among others. However, the use of other part of hypoxis plant as medicine is vital for conservation purposes. The roots attached on the corm of H. hemerocallidea corm contain hypoxoside, but the roots are usually ripped off during the preparation of hypoxoside containing traditional medicines and other herbal products. A developed and validated affordable but reliable high performance thin layer chromatography (HPTLC) densitometry for the rapid and repeatable visualization and quantitative determination of hypoxoside from roots of H. hemerocallidea was determined. The hypoxoside was visualized at Rf of 0.30 in CHCl3:MeOH:H 20 (v/v/v) using the method with a good linearity of 0.9565 over a calibration range 0.20-1.80 ng band-1. The LOD and LOQ was 5.08 and 16.76 mg band-1, respectively while the percentage recovery and the method repeatability (%RSD) was 84.10 and 4.98 were within limits regarded as acceptable for the analysis of plants and other botanicals. The roots contain 382.18 ng/band of hypoxoside
- Young Researchers Forum
Location: Hyatt
Session Introduction
Nurul Qamariah
Muhammadiyah University of Palangkaraya, Indonesia
Title: ETHNOBOTANICAL STUDY OF QUR`AN PLANTS
Time : 10:40-11:00
Biography:
Nurul Qamariah was born in Palangkaraya, Indonesia, in 1990. She received the B.E degree in Chemistry Education from Palangkaraya University, Central Kalimantan, Indonesia, in 2011, and the M.Sc degree in Pharmacy Herbal Medicine from University of Indonesia, Indonesia, in 2014. In 2014 She joined Faculty of Health Science, Muhammadiyah University of Palangkaraya, as a Lecturer. Since 2015, she became Head of planning and database division of Muhammadiyah University of Palangkaraya. Her current research interests include herbal medicine, natural product, and ethnobotanical.
Abstract:
In Islam, ethical teachings of biomedical ethics are linked with Holy Qur`an and Prophet Muhammad (PBUH). Qur`an is the central religious text of Islam, which Muslims believe to be a revelation from God. The Quran is divided into chapters (surah in Arabic), which are then divided into verses (ayah). Qur`an mention a great number of wild plants that are still used in folk medicine. Qur`an is one of the best reference books describing the importance of plants for medical benefits, where there are 28 Chapter (Surah) those mentioned specific name of plants in Al-Qur`an. This paper aims to compile the up-to-date information about some medicinal plants that mentioned in Al-Qur`an. Based on the collected data, there are 27 plant species mentioned in Al-Qur`an. In this paper, plants species were arranged in systematic order of identity of plant (The identity of the selected plants were confirmed from existing literature such as, books, journal article, and family and species of plants were confirmed from nomenclatural and bibliographic database), followed by Indonesian name, English name, Family, references cited from Holy Qur`an, part used, chemical constituents, and efficacy of herbal medicine that has been used both empirically and scientifically.
Lei Gao
Hong Kong Polytechnic University, China
Title: Cardio-protective effect of Salvianic acid A in db/db mice with elevated homo-cysteine level
Biography:
Lei Gao has completed his Master’s degree of Medicine at Shandong University of Traditional Chinese Medicine, China in 2011. He was awarded the Eurasia-Pacific-Ernst Mach Scholarships in 2016 and is currently a PhD candidate
Abstract:
Cardiovascular disease is the top death cause in people with diabetes, particularly in individuals with elevated homo-cysteine (Hcy) level. Left ventricular hypertrophy and endothelial dysfunction are critical signs of heart disease and vascular disorder respectively in diabetics. Salvianic acid A (SAA) is a major active ingredient extracted from a typical traditional Chinese medicine applied in treatment of cardiovascular disease. In this study, we investigated the protective effects of SAA on left ventricular hypertrophy and endothelial dysfunction in db/db mice with elevated Hcy level and to decipher whether the cardio-protective effects of SAA involve the modulation of methylation potential and improvement of redox status in liver. Our results suggested that chronic administration of SAA suspended left ventricular hypertrophy within the intervention period (2.9% increase of left ventricular mass in SAA-treated group compared to 49.0% increase of left ventricular mass in group without treatment) and ameliorated endothelial dysfunction in db/db mice (improve endothelial-dependent vasorelaxation by 42.8% in SAA-treated group compared to group without SAA treatment). The acute vaso-relaxant effects of SAA were also assessed in ex vivo assay. Besides, the serum Hcy level in group with SAA treatment was found significantly decreased 40.8% compared to diabetes group without SAA. These observed cardio-protective effects of SAA are probably due to improved redox status induced by the antioxidant effect of SAA itself and to the increased production of glutathione (23.2% increase in SAA-treated group compared to group without SAA treatment) via up-regulation of trans-sulfuration pathway during the Hcy metabolism in liver
Sucharat Tungsukruthai
Chulalongkorn University, Thailand
Title: Cycloartobiloxanthone, extracted from bark of Artocarpus gomezianus, inhibits the migratory behavior of non-small cell lung cancer cells
Biography:
Miss Sucharat Tungsukruthai has completed her Bachelor’s Degree in science (Biology) from Chulalongkorn University in 2016. After graduation, she has studied Master Degree in Pharmacology and she is a training researcher at Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand. She interest in special pathways in cancer such as apoptosis, metastasis, and autophagy
Abstract:
Lung cancer metastasis is one of the most common causes of cancer death. The process requires tumor cell dissemination, motility, intravasation, and formation of new tumor at different sites. Natural product-derived compounds exhibiting anti-motility effects is of interest as they may serve as promising lead compounds for cancer therapy. This research aimed to investigate the effect of cycloartobiloxanthone, a pure compound isolated from bark of Artocarpus gomezianus on migration and invasion activities of non-small cell lung cancer cells. Cells were treated with various concentrations of the compound to determine cell viability using MTT assay. The migration and invasion of the treated cells were evaluated by wound healing and transwell assays, respectively. Motility-related proteins were investigated by western blotting. Here we found that cycloartobiloxanthone exhibited potent anti-migration and anti-invasion activities tested in lung cancer H460 cells. In addition, results showed that the compound suppressed cell migration by attenuated migration regulatory proteins. Together, the inhibitory activity of cycloartobiloxanthone on lung cancer migration suggests that cycloartobiloxanthone may be suitable for further development for the treatment of cancer metastasis
Alino Sumi
Martin Luther Christian University, India
Title: Traditional wisdom for contemporary health care: Ethnomedicinal plants of Sumi Nagas in Nagaland, Northeast India
Biography:
Alino Sumi is a PhD scholar of Martin Luther Christian University, Meghalaya, India in the department of Environment and Traditional Ecosystems. She has cleared the National Eligibility Test for both Junior Research Fellowship and Assistant Professorship. She is also the recipient of Martin Luther Christian University Merit Scholarship 2015
Abstract:
Ethomedicine is a study of the traditional medicine practiced by various ethnic groups, and especially by indigenous peoples. It deals with medicines derived from plants and use of different plant parts in the treatment of various diseases and ailments, based on indigenous pharmacopoeia, folklore and herbal charms. An extensive study on Ethnomedicinal plants of Sumi Nagas was conducted in four Sumi villages of Nagaland- Rotomi, Philimi, Khrimtomi and Askhomi. The survey deals with first hand information on medicinal plants used by the Sumi Nagas of Nagaland for catering to various health care regimes such as- rheumatism, bronchitis, hyperdipsia, dyspepsia, leucoderma, leprosy, scrofula, paralysis, etc . Detailed information regarding the medicinal plants, part(s) of the plants used and how they are used etc. were extracted consulting local health practitioners, elders and farmers. During the enumeration, all the plant species were arranged with their local name, distribution, family, medicinal system, part(s) used and the various uses for the treatment of diseases and ailments. Altogether, 50 (fifty) ethnomedicinal uses have been reported. Perhaps, this is the first hand investigation on medicinal plants among Sumi Nagas of Nagaland