Day :
- Recent advances in Herbs and Natural Remedies
Ayurveda-The Science of Eight Components
Homeopathy & Traditional Medicine
Antimicrobial and antifungal properties of plants and essential oils
Herbals in cancer therapy
Session Introduction
Hawa ZE Jaafar
Universiti Putra Malaysia, Malaysia
Title: Involvement of elicitated Labisia pumila Benth. biofluids in the alleviation of chemotoxicity effect and antitumor activity
Time : 12:30-12:50
Biography:
Hawa ZE Jaafar completed her PhD in 1995 from Nottingham University, United Kingdom in the area of Plant Environmental Physiology. She is very active both in environmental manipulation of herbal secondary metabolism research, and in community development of herbal materials and products. Currently, she is the Director of the University Community Transformation Centre (UCTC) UPM, and a member of the National Herbal Implementation Committee. She has published about 150 papers mostly in high impact journals, more than150 other articles in bulletin, monographs, books and chapters, and presented more than 130 papers nationally and abroad. She is very active in professional activities as a President, Vice President, Chief Editor and Editorial Member. She is also very involved in the development of Roadmap of the National Herbal Industry in Malaysia in 2010. She established the Controlled Environment System in Malaysia in 1991, and had assisted Sana’a University Yemen to establish the Protected Agriculture Centre (2006-2010).
Abstract:
Phytochemicals derived from plant sources such as phenolics, flavonoids, alkaloids, saponin, tannin and lignin are promoted for the prevention and treatment of many health conditions, including cancer, heart disease, diabetes, and high blood pressure. Recent scientific attention has been directed towards the cancer preventive potential for naturally occurring constituents of antioxidant, vitamins, flavanoids, glucosinolates and organosulfur compounds that have anticarcinogenic or antioxidant potential. Plants products are regarded as potential chemopreventive agents acts to block, reverse or prevent the development of invasive cancers. As plants are generally very responsive to biotic and abiotic factors in altering their physiological, biochemical and morphological properties, exposing herbal plants to elicitors may induce, alter or enhance synthesis of secondary metabolites. Recent work on the use from elicitated local herb biofluids in the alleviation of chemotoxicity effect demonstrated enhanced protective nature of elicitated L. pumila especially on white blood cell and organ weight, and with greater anti-tumor activity in comparison to CPT-11 drugs-treated BDF-1 mice
Mary Gillian Vellet
Registered Massage therapist and Registered Psychotherapist, Canada
Title: Facilitation of body mapping and manual lymph drainage with phyto-rx and healium essential oils is a holistic and body-centered approach to treating diverse conditons.
Time : 12:50-13:10
Biography:
Gillian has an interdisciplinary background in fine art, art education, dance, art psychotherapy, massage therapy, manual lymph drainage, and essential oils. She,received a Bachelor of Fine Art, Honours Degree in 1989 from the University of the Witwatersrand, Johannesburg, South Africa. Her personal fine art process explores the sacred interrelationship between nature and culture. Gillian is passionate about building a culture of empathy which respects emotional intelligence, diversity, expressive arts therapies, resiliency, and creative learning processes. In 1995 Gillian moved to Toronto, Ontario, to train in Art psychotherapy at the Toronto Art Therapy Institute (TATI). In 1998 she returned to Johannesburg and worked in Art psychotherapy private practice for 8 years. During this time she trained and qualified in Biodanza - a community building integrated dance movement process. In 2005 she heeded the call of spirit to return home to London, Ontario, Canada and reconnect with her ancestral heritage. Gillian trained in Massage therapy at London Medix School and became a registered Massage therapist in October 2008. She is currently working in dual practice as a registered Art psychotherapist and Massage therapist working with children, adolescents, adults, couples, parents, and elderly. Gillian facilitates the creative and body-centered approach of "Body Mapping Creative Change" which explores personal and collective identity and health concerns in conjunction with the Massage therapy technique of Manual lymph drainage with Phyto-Rx and Healium essential oil blends in separate one hour sessions. This creative synergy detoxes the waters in the body and deeply harmonizes the nervous system. Gillian's purpose and holistic vision is to help people find peace and learn to self-regulate energy in a technological culture full of stressful over-stimulation. She creatively integrates the heart with the wisdom of the body, mind, spirit, and soul.
Abstract:
"Body Mapping Creative Change" and the Massage therapy technique of Manual lymph drainage (MLD) with Dr. Mila Emerald's Phyto-Rx and Dr. Earle Sweet's Healium essential oil blends facilitate safe somato-emotional release of negative subconscious emotions, sensations, thoughts, stress, and trauma in the 'pain body'. Together this combination of modalities detox a congested lymph system; purify the waters: clear negative subconscious energetic blockages; transform the 'pain body'; deposit immune cells; neuro-balance and harmonize the nervous system; reduce acute/chronic pain, inflammation, and muscle/visceral spasms. "Body Mapping" uses material diversity to stimulate sensory-motor neurons in the fingers through drawing an image which represents your 'self-image' and/or 'identity'. This neurological activation in the fingers translates up into the spinal cord and somatosensory cortex (parietal lobes) of the brain. As a result, creativity supports a ‘relational neuroscience’ integrating right and left brain functioning alongside strengthening the emotional experience of being listened to, 'compassionate inquiry', and ‘empathy’ within the therapeutic relationship. The client is empowered to make wise and healthy choices that result from listening to the body's wisdom and being willing to creatively change and make meaning out of medical concerns. The inclusion of Phyto -Rx and Healium essential oil blends with MLD and Heat and/or Cold Hydrotherapy more rapidly detoxes cellular, organ, lymph, brain, and energetic levels. This ancient protocol increases dermal penetration of the plasma membrane with deeper skin absorption into the bloodstream and brain. As a result, there is decreased anxiety and depression; increased focus and concentration; dissolution of lung fibrosis; increased diaphragmatic breathing without bronchial spasms; increased sinus drainage; reduced fascial adhesions; increased scar tissue mobility; decreased fibrocystic breasts; increased immunity; safe, natural, anti-fungal, and anti-inflammatory restorative option for cancer prevention and recovery. The scent of essential oils elicits a powerful positive emotional and self-caring response of 'feeling good' in the body; and demonstrates the effectiveness of pure, organic, and natural herbal remedies. Scent is easily inhaled and opens lung alveoli to reduce lung fibrosis and scarring due to a history of asthma. Scent also stimulates the olfactory system which is closely connected to the limbic brain or neural circuitry underling anxiety and fear: (ie. hippocampus - long- term memory; amygdala - emotions; hypothalamus - autonomic nervous system and hormones; and cingulate gyrus - regulates blood pressure, heart rate, and attention). It is for this reason that essential oils have such a profound calming, neuro-balancing, and regulating effect on the physiological, visceral, emotional, psychological, and energetic systems. "Body Mapping" and MLD with Phyto-Rx and Healium essential oil blends is effective in the treatment of egs: anxiety, depression, PTSD, Bi-polar personality disorder, ADHD, learning disability, grief, hypersensitivity, digestive problems, IBS, emotional eating disorder, sexual abuse, whiplash, DDD, asthma, sinusitis, scoliosis, trauma of being bullied, mastectomy, lumphectomy, lymphedema, lipedema, and cancer recovery. Gillian will present 3 case studies to demonstrate the effectiveness of "Body Mapping" and MLD with specific Phyto-Rx and Healium essential oil bends with a 14 year old girl with eczema; 46 year old woman and mother living with lipedema and lymphedema; and 56 year old woman and mother in cancer recovery.
Pallavi Lavhale
RamEesh Institute of Vocational and Technical Education, India
Title: Preparation and Physicochemical characterization of ingredients of Indian Traditional Medicine, Mahamrutyunjaya Rasa
Time : 14:10-14:30
Biography:
Pallavi Lavhale completed her M.Pharm., Ph.D. from The M.S. University of Baroda, Vadodara, Gujarat, India in 2010. Presently, she is working as Associate Professor and Department Head (Phytochemistry and Pharmacognosy) at RamEesh Institute of Vocational and Technical Education, Greater Noida. Pallavi has expertise in the field of phytochemistry, quality control and standardization of herbal/ayurvedic formulations, analytical method development-validation for herbal/ayurvedic formulations and intellectual property rights. She has published a number of papers in national and international journals and participated in a number of conferences.
Abstract:
Mahamrutyunjaya rasa is an ayurvedic formulation used in the treatment of cardiac disorders. It contains roots of Aconitum ferox, Solanum indicum, fruits of Piper longum, Piper nigrum, Sulphur, Cinnabar and sodium metaborate. As per traditional literature (Bhaishjaya Ratnavali), some raw materials need purification (shodhana) before incorporation in the formulation. This work presents a comprehensive physicochemical characterization of raw materials, intermediates and the final product obtained during purification, using modern analytical techniques. The Fourier transform infra-red spectroscopic analysis of the alkaloidal extracts of Aconitum ferox showed loss of an ester group with shift in the peaks from 1720 cm-1 (C=O stretching of esters) to 1676 cm-1 (C=O stretching of Ketone) which signifies the conversion of alkaloid Aconitine (LD50 - 0.08mg/kg) to Benzoylaconine (LD50 - 24mg/kg) improving its safety. The analysis of sulphur by X-ray diffraction and Differential Scanning Calorimeter showed that purification brought about transformation of orthorhombic sulphur into monoclinic sulphur and it reverted back to original form with higher purity. The treatments given to sulphur and cinnabar with organic compounds made them homologous to the body tissues. Analysis of purified sodium metaborate showed that the processing led to loss of water and slight change in the crystal structure with the shift in the endothermic peak from 110.6°C to 104.2°C. Thus, the present study provides a scientific backing to the methodologies used by Ayurvedic practitioners. The study also provides physicochemical fingerprints for the standardization as well as characterization of raw materials and forms a technical platform for manufacturers to develop quality control standards.
Joanna Rogister
Life Stages Holistics, Canada
Title: Safe, effective, natural: overcoming ADD/ADHD with homeopathy
Time : 14:30-15:15
Biography:
Joanna Rogister is a Homeopath and a Registered Holistic Nutritionist with Life Stages Holistics. The combination of Homeopathy and Nutrition together allow Joanna to help her patient’s attain balance within their lives while maintaining that success with nutrition. Introducing the connection between the mind and the body utilizing a variety of therapies brings achievement of long term health. Joanna specializes in dealing with health issues associated with different life stages, in particular menopause, andropause, chronic degenerative diseases and ADD/ADHD.
Abstract:
The rate at which ADD/ADHD is diagnosed and prescribed for is growing at an alarming rate each year. Between 2007 and 2011, physicians prescribed powerful psychiatric drugs at an increased rate of 28% despite the fact that studies show that the most commonly prescribed medications have little or no effect in the long term. Homeopathic remedies, which are prescribed based on the individual’s mental, emotional and physical symptoms rather than the diagnosis, are proving to significantly reduce the symptoms that patients are experiencing. Results are often seen within days with long term results demonstrating noteworthy reduction of all symptoms utilizing remedies that are completely natural and safe. Employing research results and case studies, the success of homeopathic remedies in treating these disorders can be demonstrated to bring about change in existing treatment protocols and improving the health of young and old with this disorder.
Muhammad Tayyab Akhtar
University Putra Malaysia, Malaysia
Title: Metabolic changes in obese diabetic rats treated with ‘Andrographis paniculata’ extract determined by 1H NMR-based metabolomics
Time : 15:30-15:50
Biography:
Muhammad Tayyab Akhtar has done his PhD in 2013 from Leiden University, Netherlands. During his PhD research, he used zebrafish as a model organism to study the toxicological, behavioral and metabolic effects of cannabinoids. Currently, he is working as a post-doc researcher at Institute of Bioscience of University Putra Malaysia.
Abstract:
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by high blood glucose level or hyperglycemia. It is caused either by insulin deficiency (Type 1DM) or often combined with insulin resistance (Type 2 DM). Currently, 387 million people worldwide are suffering with diabetes and this number is expected to rise to 592 million by 2035. Andragraphis paniculata (A. paniculata) is an anual herb and widely cultivated in Southeast Asian countries for its medicinal use. In recent investigations, A. paniculata was found effective against Type 1 DM. In order to test the anti-diabetic activity of A. Paniculata aganist type 2 DM. Here, we used a non-genetic out-bred Sprague–Dawley rat model fed with high-fat diet (HFD) for obesity (model 1) and combination of HFD with a low-dose of streptozotocin induced to develop an obese-diabetic rat model (model 2). Proton Nuclear Magnetic Resonance (1H NMR) spectroscopy in combination of multivariate data analyses was used to evaluate the A. paniculata and metformin induced metabolic effects on obese and obese diabetic rat models. Compare to the normal rats, high levels of creatinine, pyruvate, acetoacetate and acetate were found in the urine of obese rats. Whereas, obese-diabetic rats were marked by high glucose level, and low creatinine, 2-oxoglutarate, citrate, succinate, and hippurate levels. Treatment with A. paniculata leaf water extract (at a dose of 200 mg/kg body weight) was able to partially restore the disturbed metabolism of an obese-diabetic animal model back towards normal conditions. A. paniculata increased the levels of creatinine, alantoin, malonate and hippurate, whereas, significantly decreased the levels of glucose and taurine in obese-diabetic rats. The use of metabolomics was found to be a practical and useful approach towards understanding the effects of A. paniculata water extract on the body fluids of diabetes-induced rats.
Anirban Sukul
Sukul Institute of Homeopathic Research, India
Title: The effect of potentized mercuric chloride on alpha-amylase is transported from one test tube to another, connected through capillary water
Time : 15:50-16:10
Biography:
Anirban Sukul completed his PhD from Visva-Bharati University and Research Associateship from the same University. He studied homeopathy and obtained Bachelor degree. Presently he is the Director of Sukul Institute of Homeopathic Research at Kolkata, India. He has published 22 papers in international journals and co-authored a book published by Kluwer Academic Publishers, The Netherlands. He has lectured on homeopathy in 12 countries across Europe and UK. He has been conferred the Junior Scientist Award, Life Time Achievement Award, Gold Medal Award, Man of Excellence Award etc from abroad. Dr Sukul is also Member, Liga Medicorum Homoeopathica Internationalis (LMHI), Germany
Abstract:
Earlier we showed that treatment on plant or animal with a potentized substance might affect other plants or animals connected to the former by the capillary water in cotton threads. The aim of the present study was to establish whether drug effect could be transferred in a cell-free medium. Two test tubes each containing 1ml of 1% starch solution and 1ml of α-amylase, were connected by means of wet cotton threads encased in a polythene tube. One of the tubes also contained Mercurius corrosives (Merc-cor) 30CH and the other ethanol solution (control). After 15 min, the enzyme activity was stopped with DNSA, and the breakdown product of starch, maltose was estimated. A third separate tube contained all the tested materials except for Merc-cor and the controlled solution. In a second experiment 2 tubes, one containing 1200ppm and the other 200ppm of maltose, were similarly connected over 15 min. Both the experiments were repeated 20 times. In the first experiment, the amount of maltose was similar in both connected tubes, but it was significantly lower in the unconnected tube. In the second experiment, maltose concentration in both tubes remained unchanged. The information of Merc-cor 30CH was effectively transported through capillary water between 2 tubes in cell-free medium. Water seems to the most portable carrier of information in potentized solutions.
Bhavana B Bhat
Manipal University, India
Title: Quality of Life and Clinical Efficacy of locally used polyherbal formulation among Type II Diabetes Patients
Time : 16:10-16:25
Biography:
Bhavana Bhat has completed her MPharm and MBA from Manipal University and Sikkim Manipal University respectively. She is presently working as research scholar under structured PhD programme offered by Manipal University on adverse drug reactions of herbal medicines. She has published several articles in reputed journals and also presented research abstracts in conferences. Also delivered a few talk in conferences and seminars.
Abstract:
Introduction: Ayurveda due to its special treatment methods can be an effective solution to treat diabetes patients. INSOL-N, a proprietary antidiabetic formulation containing several herbal medicines developed by Muniyal Ayurveda hospital, Manipal was found to be effective in treating diabetes. Objective: To find the clinical efficacy and improvement in quality of life among type II diabetes patients who are put on INSOL-N. Methodology: 51 diabetes patients from Udupi and Manipal, Karnataka, India who were put-on INSOL-N were included in the study. Clinical efficacy of INSOL-N was noted on Day 1, Day 15, Day 30 and Day 90 by estimating the FBS and Hb1ac level. Patients’ satisfaction to medication and Improvement in quality of life was estimated using Diabetes Mellitus Satisfactory Tool questionnaire and SF12V2 (Permission was obtained from Quality Metrics). Results: Reduction in fasting glucose level and HbA1c was up to 40% and 30% respectively for a period of 3 months. 70% of the patients were suffering from two or more risk factors. Patients’ satisfaction was calculated and was found to have improved by 44.43% from day 1 to day 90. Physical component score showed an improvement of 30.01% and mental component score showed an improvement of 52.52%. Conclusion: INSOL-N was found to reduce the blood sugar levels and HbA1c levels. There was improvement in quality of life and patients’ satisfaction during 3 months of treatment. Also mental well-being summary was better when compared to physical well-being summary. This might be due to general perception of patients’ that ayurvedic medicines were very effective with lesser side effects.
Lakshmi Huttada
Karnatak University, India
Title: Unravelling the medicinal potencies of unexploited species of Gentianaceae family - Exacum pedunculatum
Time : 16:25-16:40
Biography:
Lakshmi H V has completed her Master's degree in Biotechnology from Kuvempu University, Karnataka and presently pursuing doctoral studies in the Department of Biotechnology in Karnatak University, Dharwad, India. She worked as Senior Research Fellow in a DBT project titled “Comparative Analysis of Functional and Anonymous SNP Diversity in Legumes : PCR based direct (gene based) and indirect (marker-based) tools for Legume Genome Analysis”, in Marker Assisted Selection Laboratory, Gandhi Krishi Vignana Kendra, University of Agricultural Sciences, Bangalore, Karnataka, India.
Abstract:
Natural products and medicine have been closely linked from the ancient times through the traditional practices. Plants belonging to the family Gentianaceae are used in herbal medicine to treat various ailments. Scientific developments have allowed progress in understanding the mechanism of action of the traditional medicines. Although most herbal medicines have a long history of traditional use, only their experimental validation gives a clear idea about its safety and efficacy. Exacum Pedunculatum is phytochemically unexplored, traditional medicinal herb. Because of its bitter taste, local people used it as a remedy for diabetes and skin diseases. Present study provides a thorough assessment of the profile of the plant to ensure the rational use in diabetes management. The identification, isolation and biological studies like preliminary phytochemical analysis, Thin layer chromatography, UV-Visible spectroscopy, FT-IR, HPTLC, GC-MS, NMR studies was performed on the plant extract of Exacum pedunculatum. In vivo validation provides an indication of the relative toxicity of the plant. By anticipating potential toxicities or possible herb-drug interactions, by In vivo studies, key parameters like Adsorption, Distribution, Metabolism, and Excretion were screened for the use of plant in therapeutic management. Further, analyzing the results of the molecular composition of the extract as potential candidates for developing new therapeutic agents, implication of bioinformatic tools to predict the properties of biologically active components by docking with natural ligands was done for future studies towards therapeutic inventions of Diabetes Mellitus.
Hassan Awad Ahmed Mohamed
Saratov State University, Russia
Title: Isolation and identification of some secondary metabolites from associated apple plant fungus Aspergillus tubingensis
Time : 16:40-16:55
Biography:
Hassan Awad Ahmed Mohamed is a PhD student at Saratov State University, Russian Federation. He is Assistant Lecturer, Faculty of Science, Al-Azhar University, Egypt. He has already published and has attended in international conferences. Now, he is preparing to submit many publications in different journals related to Microbiology.
Abstract:
Filamentous fungi in the Aspergillus tubingensis (strain AN103) is a black Aspergillus belonging to the Aspergillus section Nigri, represent some of the most widespread food, fruits and feed contaminants known, but they are also some of the most important workhorses used by the biotechnological industry as study strain after it was isolated from golden delicious apple fields at Volga region, Saratov city, Russia. Black Aspergilli were found in 19 of 28 different apple stem samples, ranging from 10 to 45 colony forming units per 10 cm stem surface. This species morphologically resembles Aspergillus niger. Among the secreted extract components, six dimeric naphtho-g-pyrones, named Fonsecin (1), Pyranopyrrol A (2), Rubrofusarin B (3), Citreonigrin E (4), Cyclopenol (5) and a New Asperazine Derivate (6) were isolated from apple associated endophytic fungus Aspergillus tubingensis (AN103) cultivated in solid rice medium. The fungal isolate (AN103) was morphologically characterized by performing cotton blue staining and molecular characterization performed by ITS1, 4 rRNA gene sequence analysis and it was confirmed as Aspergillus tubingensis. Fungal metabolites and their structures were elucidated by spectroscopic methods, including HPLC, LC-MS- and 1H-NMR.
Sergio Andres Cabrera Navarro
SENA Regional Tolima, Colombia
Title: Antioxidant and antimicrobial potential of the hidroalcoholic and aqueous extracts of the Cholupa (Passiflora maliformis)
Time : 16:55-17:10
Biography:
Sergio Andrés Cabrera Navarro is an Agroindustrial Engineer and, currently, he is studying his Master’s Degree in Agrofood Science at the University of Tolima-Colombia. He is a Consultant of the nanotechnology and biotechnology line of the Tecnoparque Nodo La Granja-SENA Regional, Tolima. He has researched on bio-compounds, phytochemicals, antioxidants and antimicrobial on natural products. He has published and article related to the antioxidant and antimicrobial activity of the extracts of Granadilla (Passiflora ligularis). Currently, he supports the development of innovative prototypes for agro-industrial companies in the Tecnoparque-SENA Tolima, Colombia.
Abstract:
The Cholupa (Passiflora maliformis) is an exotic herbal-fruit, highly desired by its sensory qualities. In Colombia, the Cholupa’s crop has been mainly destined to the fresh consumption. However, the current increment of degenerative diseases among people such as cancer has proposed the Passiflora gender as an alternative worldwide for their pharmaceutical properties, which gives to the crop a promising future in the world market. The main objective of this study was to determine the antioxidant and antimicrobial activity in aqueous and hydroalcoholic extracts of Passiflora ligularis. It was used the reflux extraction method, using as solvent water, ethanol 35% (v/v) and 70% (v/v), working with leaves and flowers as plant material. The analysis demonstrated that both aqueous and hydroalcoholic extracts present phenolic compounds, achieving maximum levels of 7.35 mg Eq Ac. Gal/g dry matter. Also was determined the maximum total flavonoids equivalent to 11.94 mg Eq Vitexin/g dry matter on hydroalcoholic extracts. In vitro antioxidant activity of the extracts was evaluated using the methodology of capturing the free radical (DPPH) and Ferric Reducing Power (FRAP), in both methods was determined that hydroalcoholic extracts were more active. The corresponding test antimicrobial activity indicated that the extracts of Passiflora maliformis have the ability to reduce the growth of both E. coli (ATCC 25922) and S. aureus (ATCC 25923), mainly finding that aqueous extracts possess greater power microbial inhibition than the hydroalcoholic ones. In this study, it also was possible to identify a correlation between the phenols and antioxidant activity (FRAP).
Deepak Francis
Ariston Schol of Business Studies
Title: A studyof current status of natural herbs and medicinal plants in kerala
Biography:
Deepak Francis has completed his BSC at the age of 22 years from keralaUniversity and doing graduate studies from ariston school of business studies. He came from a tradional ayurvedic family in kerala. He isdoing reserach on preventive medicine for cancer and dibetics.
Abstract:
Home medical knowledge, or knowledge of how one’s surroundings can be used to maintain and restore health, can be an important tool for health self-sufficiency in rural places as well as for the ecological conservation of important plants and natural materials. The Indian state of Kerala has a rich heritage of traditional medicine, found in the historically inter-related forms of codified Ayurveda and folk knowledge. In thrissur district, a region of Kerala nestled in the hills of the Western Ghats, rural households engage in small-scale home-gardening and agroforestry, which in addition to providing nutritionally diverse food is a source of medicinal herbs and home remedies. This study interviewed 35 households in the village of peechi, Thrissur District regarding their knowledge and utilization of herbs and home-remedies. morethan 75 local plants and substances were identified as being used by villagers for medicinal purposes, to cure or prevent wide varieties of ailments. Families with extensive use and knowledge of home medicine also engaged in intensive home gardening practices which integrated their food and medicine cultivation. While a basic knowledge and use of at least a few medicinal plants in the home is nearly ubiquitous, more extensive knowledge of advanced remedies and plants is still present but quickly disappearing. Though a majority of families responded that they find natural remedies to be superior to Allopathic ones, many of these are increasingly relying on Allopathic medicines. Factors found to be contributing to this paradox include changing lifestyles, the convenience factor of Allopathy, and diminishing home-cultivation of medicinal plants.
Abiola Fatimah Adenowo
University of Zululand, South Africa
Title: Aqueous extract of Monodora myristica ameliorates cadmium-induced hepatotoxicity in male rats
Time : 17:25-17:40
Biography:
Adenowo Abiola Fatimah is presently a PhD student at University of Zululand, Republic of South Africa. She completed her Masters’ degree in Biochemistry in College of Medicine, University of Lagos, Nigeria. She has four papers published in reputed journals.
Abstract:
This study investigates the protective effect of Monodora myristica (MM) on cadmium-induced liver damage in experimental animals. Experimental rats were divided into five groups (G1– G5): G1 was maintained on tap water only and served as the negative control, G2 – G5 were maintained on cadmium in the animals’ main drinking water for 21 days to induce hepatotoxicity. G2 served as the positive control (cadmium only); G3 and G4 were treated with aqueous extracts of MM at a dose of 200 mg/kg bw and 400 mg/kg bw respectively, G5 was treated with 20 mg/kg bw of Livolin forte (LF). At the end of the experiment, levels of hepatic enzyme biomarkers alanine transaminase, alkaline phosphatase, aspartate transaminase, total cholesterol, triacylglyceride and malondialdehyde were significantly raised in the cadmium treated groups. Conversely, cadmium treatment elicited noticeable decrease in hepatic antioxidant enzymes reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD). Co-treatment with MM at varying doses as well as LF considerably decreased the elevated levels of the hepatic biomarkers as well as TC, TG and malondialdehyde in the cadmium-treated groups with the effect more pronounced in G4 and G5. Treatment groups (G3 – G5) also exhibited the reversal potential of MM and LF on cadmium toxicity at the tested doses as their administration was accompanied by a pronounced increase in the levels of these enzymes. These results demonstrates that aqueous extracts of MM is effective in the amelioration of hepatic damages arising from cadmium-induced toxicity, indicating that the antioxidant bio-constituents of MM play an important role in the prevention of liver toxicity possibly by inhibiting bioaccumulation of free radicals in animal models.
Russell Jaffe
PERQUE Integrative Health, USA
Title: Rethink Health: Standardized herbs personal predictive biomarkers interdependent sustainability
Biography:
Russell Jaffe received his BS, MD and Ph.D from the Boston University School of Medicine in 1972 and residency in clinical chemistry at the National Institutes of Health (1973 – 1976). He is board certified in Clinical and Chemical Pathology and has considerable expertise in Traditional Chinese Medicine, acupuncture, active meditation, homeopathy, and manipulative arts. Dr. Jaffe started the Health Studies Collegium, a think tank that focuses on sustainable solutions to global health needs and is the Lab Director of ELISA/ACT Biotechnologies that offers the only lymphocyte response assay for detecting delayed hypersensitivities and is CEO of PERQUE Integrative Health, a company that offers the world premier nutraceuticals and scientifically proven, integrative health solutions speeding the transition from sick care to healthful caring.
Abstract:
Epigenetics includes everything that our habits and life style influence and by which individuals are influenced. The consensus from the National Institutes of Health, World Health Organization and Institute of Medicine is that 92% of lifetime health is due to the details of what people eat, drink, think and do. More recent studies confirm how quickly the metabolism (metabolome) and digestion (microbiome) are modified when consumption, activity, attitude and environment are modified. Treatment outcomes based on symptoms suppressed are more costly and less effective than those based on promoting the causes of good health and avoiding the consequences of ill health. Beginning with the fundamentals, this presentation will discuss 8 validated functional predictive biomarker tests. The emphasis on these tests brings out the importance attached to physiology, fundamental to traditional healing in charting out the course of a healthy life now and in the future; pillars of a personalized, evidence based practice today. Resources will be highlighted to facilitate the learning curve for those interested in a modern ReThink Health look at herbals as part of the cost and outcome effective solution set to the conventional sick care/healthcare systems. From Gerard’s Herbal to Commission E Monographs to Jim Duke’s compendium (http://www.ars-grin.gov/duke/) and from Mark Blumenthal’s American Botanical Council (http://abc.herbalgram.org/site/PageServer to lymphocyte response tests for immune responses to herbs, this presentation highlights resources and opportunities to use better quality herbals in quality assured systems. Emphasis will be on documenting the value of health promotion (or risk reduced) through use of smart, convergent technologies- high sensitivity predictive biomarker tests. We will also talk about the Alkaline Way program- a lifestyle modality which combines with predictive biomarker tests and self-assessments and aims to serve as an individual’s health promotion plan for functioning better today and living better tomorrow. When applied through health coaches, proactive health professionals, through media and public service announcements, this approach, fully implemented, can save 10 million lives over a decade and add $80 trillion to the country’s balance sheet.
Dalal Akoury
Integrative Addiction Institute, USA
Title: Nutritional and botanical modulation of the reward circuitry—limbic, hpa, and Autonomic nervous system— as an adjunct in addiction therapy
Biography:
Dalal Akoury practices Integrative Addictive Treatment, Integrative Cancer Treatment, Age Management and Lifestyle Medicine, focusing on customized nutrition and fitness programs. She is the owner and founder of her private practice, AWAREmed Health & Wellness Resource Center. Dr. Akoury is fellowship trained and certified in Integrative Cancer Therapy, Anti-Aging functional and regenerative medicine, as well as having more than twenty years of accumulated experience in emergency medicine, pediatrics, and a master’s degree in public health. Her lifetime of experience, along with a unique sensitivity and a driving passion to inspire health in everyone has prepared Dr. Akoury to be the doctor she is today helping both women and men resolve symptoms, including weight gain, sexual dysfunction, declining energy levels, and stress brought on by menopause and andropause.
Abstract:
Addiction is a primary, chronic disease of brain reward, motivation, memory and related circuitry. Dysfunction in these circuits leads to characteristic, biological, psychological, social and spiritual manifestations. The goal of the integrative botanical holistic addiction treatment is to restore balance and wholeness in the lives of the people who come for help. Emerging on the horizon in addiction therapy is an expansion of the scope of treatment beyond drug replacement and maintenance therapy approaches to include molecular management of addiction physiopathology. The goal in these integrative approaches, which extends beyond replacement of the addictive substance, is to “re-wire†the reward circuitry and create a new memory free from harmful cravings. Called neuroplasticity, this re-wiring of the nervous system could be accomplished through an herbal blend of nervine a natural restorative ecological system that enables the brain to create new healthy neural pathway. Nervines are plant remedies that restore balance and wholeness in the brain of the addict. Western Herbalism today differentiates between three kinds of herbs that act on the nervous system, collectively called nervines. These are nervine tonics, nervine relaxants, and nervine stimulants. One key new approach in the treatment of addiction appears to be modulation of the methylation and inflammatory cascade. Evolving expanding research links addiction initiation, promotion, and progression, to autonomic imbalances, methylation flaws and inflammatory events. This presentation offers a literature review of the evolving relationship between addiction and neuroendocrine imbalances, with a focus on autonomic imbalances disrupting the reward circuitry and creating a Reward Deficiency Syndrome (RDS). Accentuating the role of nervines in restoring the brain ecological landscape including autonomic balance proposing an effective anti-addictive actions in a neuro-degenerated brain. Selected nutritional and botanical agents represent an overlooked but crucial component in complementary addiction therapies. Herbs that act on the nervous system are collectively called nervines. These nervine tonics, nervine relaxants, and nervine stimulants are capable to modulate and revamp both the nervous and autonomic nervous system and may advance the efficacy of addiction therapy.
Feather Jones
Clinical Herbalist, USA
Title: Botanical and supplemental support for cognitive impairment in the aging adult
Biography:
Feather Jones is a Registered Clinical Herbalist in Western Herbalism who integrates herbal remedies, holistic nutrition, flower essences and stress reduction guidance. Her 30+ year career in teaching herbal medicine and clinical practice, coupled with a background in Native American (Mandan) tribal teachings, provides her clients and students with a synergistic approach to health and healing. She is Adjunct Instructor of Botanical Medicine at the Southwest College of Naturopathic Medicine in Tempe. In Boulder, Colorado, she founded and directed the Rocky Mountain Center for Botanical Studies, a certified herbal school housing one to three year programs in Western Herbalism. As well, she was twice past president for the American Herbalists Guild. She holds a certificate from the Santa Fe College of Natural Medicine as Clinical Herbalist from 1982. She is an herbal consultant and herb walk instructor for the Expo West Natural Products Trade show. She offers classes in Western Herbal Medicine open to the public as well as various gatherings and conferences around the country. At present, she chairs the Small Business Committee for the American Herbal Products Association. She is owner and president of Sedona Tea Blends, an organic herbal tea company. Sedona's famed vortex energies and selected desert flower essences are infused into a mandala of medicinal botanicals that provide a wellness tea for body, mind and spirit.
Abstract:
As we age, our memories can get sketchy and mental alertness and acuity can dull. When asked, many elders have stated their most important health concern is not cancer or heart disease but cognitive impairment. They want to remember the moments in their lives and draw upon that wisdom that life experience brings. Cognitive disorders & dementia destroys memory and undermines personality and emotional stability. With the present array of AD drugs that display more adverse reactions than benefits, one can see how prevention is the best strategy. As an herbalist, we have generations of safe and effect uses of our beloved plant medicines. This class is designed to introduce you to botanical medicine and its allies for the central nervous system and mental clarity. We will briefly look at the role of genetics, cell biology factors, aluminum and other heavy metals. We will focus on nutritional support through foods and supplements high in antioxidants, fatty acids and phospholipids. Botanical therapies will be explained in detail from adaptogens to GABA agonists and flower essences.
Angela Hope-Murray
Ayurvedic Practitioner, UK
Title: Looking at modern dietary principles in lights of Ayurveda
Biography:
Angela has dedicated her life to both orthodox and complementary health care. Her career, which spans 40yrs, began as a Podiatrist in the NHS UK. Moving to the U.S in 1979 she spent 5 yrs. in the Boston’s Lemuel Shattuck Hospital where she spent 5yrs in the ground breaking Pain and Stress relief clinic headed up by Professor Ted Kaptuck and gained a M.A in Nutrition and Health Counseling. In 1986 she began training with Dr Vasant Lad and Robert Svoboda and the same time she was initiated into the Adviata Vedanta tradition. Returning to England in 1989 she began practicing at The Hale Clinic and gained a BSc in Osteopathy in 1997. Ayurvedic training continued at the UK College of Ayurveda and culminated in an MSc in Ayurvedic Medicine in 2009 at Middlesex University. She lectures extensively around the world and has published Healing With Ayurveda in 1998 and Ayurveda For Dummies in 2013.
Abstract:
Ayurvedic nutrition places great emphasis on good dietary principles both in disease management and health maintenance. In western dietetics nutritionists have veered away from using grains and dairy, which are some of the mainstays of Ayurvedic Ahara or diet. This has led many Ayurvedic Practitioners and physicians into difficulty when prescribing dietary interventions to their patients. This lecture will examine the possible causes of this situation and what can be done to help rectify this state of affairs. Bearing in mind that Charaka informs us in Samhita Vimansthan 8/14 that the science of Ayurveda is a dynamic understanding of the creation and as such is able to inculcate modern theories and practices. This talk will seek to increase our understanding and therefore optimize the treatment of individuals in the realm of nutrition. With this in mind there will be an examination of modern food production, cooking methods, farming practices and storage. This will help enable practitioners to enhance their treatments in the realm of dietetics.
Biography:
I am an herbalist and botanist who specializes in biomedical/dietary supplement regulations and regulatory affairs. In my experience, being prepared goes a long way towards creating a positive relationship with the FDA. My familiarity with this process can function as a vital resource, allowing you to focus on creating and sharing your vision with the world while I focus on the paper work and regulations. In addition GreenTree Consultants provides access to a host of valuable resources and techniques for health care professionals and wellness centers that are working to provide consistently high-quality botanical remedies. We are experts in the age-old practice of crafting plant medicine, and as GreenTree Consultants, we hope to partner with you in order to help shape the growing confluence of ancient healing methods and the best of modern medical science. At Bastyr I lecture on various topics concerning botanical regulation and quality control.
Abstract:
This presentation explores the world of botanical regulation. Topics will provide insight into the processes involved in legally manufacturing, distributing, and advertising botanical products as dietary supplements or botanical drugs within the United States. If time allows this presentation will also introduce attendees to international botanical regulations and provide context for these regulations on a global front.
Peters CJM
Europa Ayurveda Centrum, Netherlands
Title: Mohana choorna a traditional ayurvedic herbal preparation against a modern common disease: diabetes mellitus 2
Biography:
Peters CJM is Director at Europa Ayurveda Centre.The European Ayurveda Centre (EAC) is an agricultural estate with treatment and research facilities specializing in traditional Ayurveda. The Centre was founded by the Ayurvedic doctors Dr. V.P. Mohana Kumari, Ing. Cornelis Peters, and Vighnesh Maharaj. Together they form the inspirational driving force behind this centre. Cornelis earned his M.D. at HBO University in 2003. He is a Promoter of Scientific Research on Medicinal Plants Enhancing People's life Coping with Lifestyle Diseases.
Abstract:
Diabetes mellitus, often simply referred to as diabetes, is a multi-system dysfunction in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. Also, there are several factors that are not obvious from biological considerations alone. Therefore, the search for a single drug target to the reversal of all or majority of the aspects of the disease might not give the solution because biological systems are too complex to be fully understood through conventional and isolated experimentations, as they are not always linear. The Ayurvedic herbal formula MC contains a variety of herbal ingredients that incorporate synergistic, potentiative, agonistic, antagonistic pharmacological agents, and hence act on a variety of targets by various modes and mechanisms. Therefore, the therapeutic approach of MC is more holistic than regularly used Western medicines for DM2. There are significant changes in the system biology after the use of MC resulting in lowering blood sugar levels (glycosylated haemoglobin) and blood lipid levels (triglyceride, total cholesterol, Low Density Lipoprotein and High Density Lipoprotein) in DM2 patients. It is interesting to find out which plant compounds, including already proven health-promoting metabolites, are present in the 20 herbs comprising MC, which are cultivated using a traditional Indian method of natural fertilizer (Panchagavyam). The herbal medicine is analysed using a holistic, unbiased metabolomics approach and the system (patient) is analysed using a holistic unbiased approach by expression analysis of hundreds of genes and physiological parameters. Finally, the methods of cultivation are researched so that the homogeneity of components is maintained and that the composition of the herbal preparation is standardized as much as possible. For these studies research collaboration between Europa Ayurveda Centrum, Wageningen University (two departments), Canisius Wilhelmina Hospital, and Europroxima was made. EAC cultivated the plants, and made the herbal preparation. Europroxima tested on safety of the herbal material. WUR-PRI will do the metabolomics (compound analyses) of the plant material and the capsules. WU–Human Nutrition together with Canisius Wilhelmina Hospital worked as a research organization and clinical hospital, respectively, to execute the clinical trial. This project was subdivided into two distinguished parts and each of the parts has its own approach.In the part on the presence and quantification of (health-promoting) plant metabolites in the twenty selected herbal species, and the quantification of these metabolites and possible derivatives in the herbal preparation MC, the biochemical composition is analysed in an unbiased way via metabolomic profiling, screening thousands of compounds. A quality analysis is performed by analysing different batches of the herbal preparation for the identified metabolites in which batches will be compared on their compound composition. In addition, safety analyses on the possible presence of residues and bacterial pathogens are carried out.
James David Adams
University of Southern California School of Pharmacy, USA
Title: Proper pain treatment with plant derived medicines
Biography:
Adams earned a PhD in Pharmacology from UC San Francisco in 1981. He has been a faculty member at the USC School of Pharmacy for over 27 years. He was a student of a Chumash Indian Healer for 14 years. He has written a book and many publications on California Indian Healing. He has over 240 publications.
Abstract:
Pain can best be treated in the skin, such as with cold, heat, acupuncture and plant derived liniments. The pain cycle starts in the skin with transient receptor potential cation channels on sensory afferent neurons. These cation channels are the most abundant pain sensors in the body and are most abundant in the skin. They are regulated by prostaglandins, resolvins, endocannabinoids and perhaps other lipid derived endogenous compounds. Prostaglandins are largely made by cyclooxygenase-2 that is induced in the skin during chronic pain conditions. Plant derived medicines are available that can be applied directly to the skin. The talk will discuss plant medicines that come from California Indian traditional healing practices. These medicines contain monoterpenoids that inhibit transient receptor potential cation channels and sesquiterpenes that inhibit cyclooxygenase-2. In general, monoterpenoids and sesquiterpenes cross the skin. Pain is inhibited by application of small amounts of these medicines where they are needed. This provides superior pain relief than oral nonsteroidal anti-inflammatory agents (NSAIDs) or oral opioids. These oral agents are used in large amounts and cause toxicity to internal organs. NSAIDs cause 100,000 ulcers in the US every year and at least 10,000 deaths. They also increase heart attacks and strokes. Opioids cause 14,000 deaths in the US every year from respiratory depression and seizures. The use of plant derived liniments has the potential to save many lives every year.
Hawa ZE Jaafar
Universiti Putra Malaysia, Malaysia
Title: Whole plant elicitation: a new approach toward enhanced production of plant secondary metabolites harvest index
Time : 04:10-04:30
Biography:
Hawa ZE Jaafar completed her PhD in 1995 from Nottingham University, United Kingdom in the area of Plant Environmental Physiology. She is very active both in environmental manipulation of herbal secondary metabolism research, and in community development of herbal materials and products. Currently, she is the Director of the University Community Transformation Centre (UCTC) UPM, and a member of the National Herbal Implementation Committee. She has published about 150 papers mostly in high impact journals, more than150 other articles in bulletin, monographs, books and chapters, and presented more than 130 papers nationally and abroad. She is very active in professional activities as a President, Vice President, Chief Editor and Editorial Member. She is also very involved in the development of Roadmap of the National Herbal Industry in Malaysia in 2010. She established the Controlled Environment System in Malaysia in 1991, and had assisted Sana’a University Yemen to establish the Protected Agriculture Centre (2006-2010).
Abstract:
Plants are remarkable source for the discovery of new products with medicinal importance and plant secondary metabolites are rich sources of bioactive constituents used in pharmaceutical industry, food additives, flavors, and other industrial materials. Plants are generally very responsive to biotic and abiotic factors known as elicitors in altering their physiological, biochemical and morphological properties. Elicitation is a process of induced or enhanced synthesis of secondary metabolites by the plants to ensure their survival, persistence and competitiveness. Elicitors are usually capable to induce various modes of plant defense including the production of ROS (reactive oxygen species), the hypersensitive response and the production of phytoalexins, i.e. antimicrobial secondary compounds. The induction of phytoalexin biosynthesis has gained special importance in biotechnological approaches as enhancers of plant-secondary-metabolite synthesis, and could play an important role in biosynthetic pathways of newly discovered enhanced biometabolites of commercial importance. Many of these compounds are of high value as therapeutics (anticancer) or otherwise biologically active agents. Although, increased production through elicitation of secondary metabolites from plant cell cultures has opened up a new area of research, the use has only had limited commercial success due to lack of understanding of how these metabolites are synthesized and high capital cost to set up the production. Whole plants elicitation grown in the field or raised under controlled environment, however, has demonstrated improved secondary metabolites production and enhanced plant growth and development. The paper discusses technique of elicitation and results on enhanced secondary metabolites harvest index of some tropical herbs that may spell future approach to production of quality herbal materials.
Richaritha Gundlapalli
Board Certified Integrative and Holistic Physician, USA
Title: Vitamin G: the medicinal aspects of green space and forest medicine (shinrin yoku)
Biography:
The presenter, Richaritha Gundlapalli MD, ABIHM, is a Board certified Integrative and Holistic Practitioner, with vast experience in holistic modalities - Ayurveda, Chinese medicine, Anthroposophic medicine, Energy medicine, Biodynamic farming. Her quest to find the source of the underlying causes of modern lifestyle diseases led her to explore intricacies of farming, humans/microbiome and human/nature interactions leading her to synthesize her findings under principle of Vitamin G.
Abstract:
In Modern lifestyle we are everyday faced with unprecedented amounts of stress and stress related health issues, ranging from hypertension, insomnia, burn out, just to name a few. One of the contributors of stress in modern life is living in an extremely toxic and artificial environment, far away from nurturing presence of nature and forest. As if on cue, there has been cutting edge research around the world that has been established immediate and high impact therapeutic nature of intimate engagement between human beings and their originally natural abode - "The forest". This presentation introduces the audience to the founding principles of “ShinrinYokuâ€, Japanese modality of forest medicine and also provides review of latest findings and suggested engagements for practitioners to support their patients. The presentation will also present a synthesis of other complementary modalities that can mitigate the modern lifestyle diseases and introduces the path breaking concepts of Vitamin G. The presentation will specifically aim to extend the understanding of natural medicine beyond the ingestible herbs rather focus on the forest medicine as a therapeutic and recuperative modality, based on the communication and energy exchange between natural elements and human beings.
Biography:
Seymour Koblin (born October 31, 1953) is an international author, composer, performer, holistic health practitioner/educator, speaker and the creator of three trademarked complementary health methods: Zen-Touch™ Shiatsu, Zen-Tone™ and Nutri-Journey™. Seymour Koblin began his path as a practitioner and educator of complementary holistic health methods after a near death experience in Toronto in 1977. He is the founder and director of two 501c3 non-profit organizations - the School of Healing Arts, founded in 1990, and the International Center for Healing Arts, founded in 2010. The International School of Healing Arts spreads his teachings throughout the USA, Europe and Mexico. All of his healing methods are based on teaching the body to regenerate itself through integrating each person’s unique balance of the forces of nature within their daily lives. Traditional Chinese Medicine applications of Nutrition, Herbs, Aromatherapy, Energetic Bodywork, Chi Exercises, Emotional Healing techniques and Intuitive development represent the focus of his work.
Abstract:
According to Traditional Asian Philosophy and specifically Chinese Medicine, healing on a deep level involves integrating the Forces of Nature: Yin/Yang-Gravity / Electromagnetic forces and the 5 Seasons more popularly called the 5 Elements into each person’s life. Every person embodies a unique manifestation of these movements. Understanding excesses and deficiencies according to one’s Constitution and Condition allows us to make recommendations for a person at the source of any symptom they present. The emotional tendencies of each movement will be described so participants can assess themselves and their clients. Emotions are the strongest form of energy available to our bodies. This workshop will teach us how to use emotions instead if them using us. Specific herbs categorized by their seasonally emotional effects can be used to tonify or disperse important emotional lessons and healing.
Henry I.C. Lowe
Medicanja Limited, W.I
Title: Medicinal Cannabis/ Ganja for Prevention & Treatment: A Case for Pain Management
Biography:
Henry Lowe, a scientist in medicinal chemistry, has contributed over 50 years in the fields of science, technology and health sciences nationally and internationally. He has earned the Order of Jamaica (2012), Commander of the Order of Distinction (1982), the Prime Minister’s National Medal in Science & Technology (2014), the Jamaica Observer Business Leader Award (2006) and the CCRP Living Legend Award (2012); and is the only Jamaican who is a member of the prestigious American Association for Cancer Research (AACR). He has discovered several bioactive molecules from Jamaican medicinal plants which are being developed for cancer therapy, diabetes and HIV/AIDS. He is also the holder of 3 patents in these areas. He has published over 22 books and has five in various stages of completion at this time. He has also published over 100 articles in the areas of science, technology and the health sciences for journals and the popular press. He was born in St. Andrew, Jamaica and was educated at Calabar and Excelsior High Schools, University of the West Indies, Mona (B.Sc. Hons.), University of Sydney (M.Sc.), Manchester University (Ph.D.), Bolton Institute of Technology England (Dip. Technical Education), Harvard University and M.I.T, U.S.A. (Post-Doctoral Studies). He is an Adjunct Professor in the Department of Medicine, University of Maryland School of Medicine, USA and Distinguished Adjunct Professor of Ethno-medicinal Chemistry, University of Technology, Jamaica.
Abstract:
The availability of Cannabinoids represents a relatively new nutraceutical/ pharmacological option which may form part of a multimodal treatment plan for acute and chronic pain. With increasing knowledge of the endocannabinoid system and compelling preclinical work supporting that cannabinoid agonists are analgesic, there is increasing attention on their potential role in pain management. A wide array of drugs ranging from analgesics (e.g. aspirin, acetaminophen and ibuprofen) to anti-migraine drugs to narcotics (opioids e.g. codeine and morphine), aim to lessen or in some cases stop pain. Undoubtedly, with the continued high incidences of pain, the efficacy of these drugs are challenged. It also raises concerns regarding long term substance abuse and dependence. Cannabinoids, as a medicinal alleviant for pain, has two-fold benefits in that it can provide relief and it can minimize the side effects of pain experienced as these may be less than those experienced with an analgesic drug or opioid. This paper is an exploration of Medicanja’s clinical research program and findings to date, that complements current studies and adds a regional perspective to the efficacy of cannabinoid extracts in the treatment and management of pain as a viable alternative to current treatment options.
A.V.Chandewar
P.Wadhwani College of Pharmacy, India
Title: Determination of pesticide residue in marketed hepatoprotective herbal formulations by capillary gas chromatography
Biography:
A.V.Chandewar is presently working as a Principal, P.Wadhwani College of Pharmacy, Yavatmal (M.S.) India and Dean, Faculty of Medicine, SGB Amravati University, Amravati, India. He did M. Pharm from RTM Nagpur University, Nagpur in 1989 (Gold Medalist) & Ph.D. in Pharmaceutical Sciences from SGB Amravati University, Amravati in 2007.He has total 25 years of teaching experience. Under his Supervision 8 students awarded by Ph.D, & guided to 56 PG students. He is associated with several professional bodies like APTI, IPA, ISP, ISTE, IHPA etc. He has published 60 research & 30 review articles in National and International journals and in a various conferences at National level. He has been awarded by Late Prof.G.B. Sing memorial Gold Medal being 1st Merit in Pharmachemistry in M.Pharm throughout University. (78th Convocation) He has been awarded by Samaj Ratna Award and Jewel of India award and presently awarded by Dr.S.G. Wadodkar Memorial teacher of the year award 2014 by APTI, MS branch. He is invited as resource persons in a various conference & seminar at National level. He worked as a Chairman of BOS & presently he is Member of Senate, Academic Council, BOE, BCUD of SGB Amravati University, Amravati, India
Abstract:
Pesticide residue refers to pesticides, their poisonous metabolic and degradation products and impurities that may remain on or in the organism, agricultural product, and the environment, after they are applied. Sometimes pesticide residue is unavoidable; however, if the residue exceeds the maximum limit or a tolerance, it will pose significant risk to humans and animals or other creatures in the ecological system, through the food chain. The Medicinal plants materials are liable to contain pesticide residue, which accumulate from agriculture practices such as spraying treatment of soils during cultivation and administration of fumigants during storage. It is therefore recommended that every country producing medicinal plant material should determine the pesticide residue. W.H.O. has established the maximum residue limit (MRL) in medicinal plants. In this research the pesticide residue in different Hepatoprotective herbal formulations were determined by Capillary gas chromatography. A Varian 6890N gas liquid chromatography equipped with a 230 m X O. 32 mm, I. d. glass column packed with SE-52, a constant current 63 Ni electron capture detector. The operating conditions were as follows: Injection volume was 2, u l; injector temperature, 200 °C; oven temperature, 160 °C; detector. Mobile Phase A: 0.1 % aqueous formic acid solution was used. From the result of determination of pesticide residue in marketed Hepatoprotective herbal formulation it was observed that the pesticide residues in formulations were present as in HP1 (Alpha HCH -0.19ppm), HP2 (diazinone-0.63ppm), HP3 (Captafol-0.39ppm, Trans Fluthrin-0.27ppm), HP4 (Beta-HCH-0.20ppm, Heptachlor -0.38ppm), HP5 (Alachlor-0.27ppm).which could produce ill effect on health of patient, using this herbal formulation.
Smriti Khatri
RamEesh Institute of Vocational and Technical Education, India
Title: Designing Development and evaluation of Floating Gastroretentive Microspheres of Acyclovir with piperine as a bioenhancer
Biography:
Smriti Khatri has completed her M. Pharm., from S.G.S.I.T.S College, Indore in 2003 and Ph.D. from J.N.U, Jaipur., India in 2012. She is working as Head of Department (Pharmaceutics) Associate Professor at RamEesh Institute of Vocational and Technical Education, Greater Noida, U.P., India. She has expertise in the formulation of dosage forms, Drug Regulatory Affairs and Intellectual Property Rights. Smriti has published more than 25 papers in national and international journals and participated in a number of Conferences.
Abstract:
Introduction: Acyclovir is an effective antiviral drug for the treatment of Herpes simplex virus. Oral bioavailability of Acyclovir is poor (15-20 %) because of low solubility and short half life. Piperine enhances the bioavailability of Acyclovir by increasing the absorption and by delaying the metabolism of the drug. Floating microspheres are prepared to retain the dosage form at the site of absorption and thus enhance the bioavailability. These are low-density system, which are having a sufficient buoyancy to float over the gastric contents and remain in the stomach for a prolonged period. While the system floats over the gastric content, the drug is released slowly at the desired rate. It results in increased gastroretentive time and reduces fluctuation in the plasma drug concentration. Methods: Ethyl cellulose and HPMCK4M were used as polymers for preparing microspheres and piperine was added as a bioenhancer to increase the bioavailability. The microspheres were characterized with respect to their morphology, particle size, encapsulation efficiency, production yield, in-vitro release and pharmacokinetic studies in rats. Result and discussion: The mean particle size was within range and showed spherical shape. Microspheres were having sufficient entrapment efficiency and floating ability and were directly proportional to the polymer concentration. Pharmacokinetic study in rats showed nearly two times higher AUC value of acyclovir for the microspheres with piperine (15614.13±6953.13 ng h/ml) as compared to drug solution (7552.33±3219.09 ng h/ml). In addition, Acyclovir microspheres showed the ability to maintain the acyclovir plasma concentration through 24 h.
Sanjay Bais
Pacific college of pharmacy, India
Title: Comparative determination of pesticide residue in Anti-diabetic herbal products marketed in India
Biography:
Sanjay K.Bais has completed his B.Pharm and M.Pharm from Sant Gadge Baba Amravati University, Amravati (M.S.). He completed Ph.D in Pharmacy from PRIST University, Thanjavur, Tamilnadu. He is the Associate Professor in Faculty of Pharmacy, Pacific University, Udaipur, Rajasthan, a premier Educational Private University. He has published more than 33 papers in reputed journals and has been serving as a review member of repute journals. He authored four pharmacy books published by Lambert Publishing house, Germany.
Abstract:
Herbal formulations are getting popular throughout the world and commercialized extensively for various medicinal properties. WHO has emphasized the need for quality assurance of herbal products, including testing of pesticides residues. In view of W.H.O guidelines, poly herbal drugs used in herbal formulations were collected from local market, for testing pesticides residue. Therefore, in the present case, we have examined few local samples of certain herbal product. The Medicinal plants materials are liable to contain pesticide residue, which accumulate from agriculture practices such as spraying treatment of soils during cultivation and administration of fumigants during storage. It is therefore recommended that every country producing medicinal plant material should determine the pesticide residue. W.H.O. has established the maximum residue limit (MRL) in medicinal plants. In this research the pesticide residue in different Anti-diabetic herbal formulations were determined by Capillary gas chromatography. From the result of determination of pesticide residue in marketed Anti-diabetic herbal formulation it was observed that the pesticide residues in formulations were present as in AD1 (Dimethoate -0.59 ppm Methyl Parathion-0..48 ppm, Methyl Chlorpyrifos-0.59 ppm), AD2 (Methyl Parathion -0.49 ppm), AD3 (Methyl Parathion -0.39ppm), AD4 (Dicofol- 0.37 ppm), AD5 (Dicofol-0.27ppm).which could produce ill effect on health of patient, using this herbal formulation.
- Medicinal & Aromatic Plants
Botanical medicines for prevention and treatment
Herbal Therapies for Prevention and Treatment
Session Introduction
Arunabha Ray
University of Delhi, India
Title: Adaptogenic effects of some medicinal plants: Integration of traditional and modern concepts
Time : 10:00-10:20
Biography:
Arunabha Ray holds an MD and a PhD and is the Chair, Department of Pharmacology at the Vallabhbhai Patel Chest Institute, Faculty of Medicine, University of Delhi. He has more than 36 years teaching and research experience in basic and clinical pharmacology and toxicology and has been the recipient of several awards and honors for research excellence. He has more than 150 research publications, is Author of several text and reference book chapters, Editor of 04 books in his areas of expertise, and Author of a textbook in pharmacology.
Abstract:
Stress related disorders contribute to a significant proportion of global illnesses and adaptogens are herbal agents which have the potential to attenuate stress effects. Since its inception, the concept of adaptogens has evolved considerably and newer mechanisms have been proposed. As these agents have to be administered for a reasonably long period of time, the benefit versus risk ratio is important and herbal agents are definitely preferable over their synthetic counterparts. The brain, HPA axis and immune system play a crucial role in the expression of the stress response and studies were conducted to evaluate the possible interactive mechanisms in the adaptogenic effects of some herbal agents. The role of CNS-neuroendocrine-immune interactions during the adaptogenic effects of agents like Ocimum sanctum (Tulasi, OS), Azadirachta indica (Neem, AI) and Withania somnifera (Ashwagandha, WS), used in traditional medicine, were investigated in experimental animals. Restraint Stress (RS) was used as the experimental stressor, and the effects of RS and their modulation by OS, AI and WS extracts were assessed in albino rats. RS suppressed neurobehavioral (elevated plus maze test), endocrinal (plasma corticosterone) and immune (humoral and cell mediated) responses – effects that were differentially reversed by OS, AI and WS pre-treatments. Herb-drug interaction studies showed that endogenous neuromodulatory substances could be involved in the observed adaptogenic effects. Such interactive studies are of great significance for the convergence of traditional and modern medicinal concepts and for the development of newer, more effective and safer herbal agents for the treatment of stress related disorders.
Azza Hafez elmedany
Alexandria University, Egypt
Title: Green tea extract: Its potential protective effect on Bleomycin induced lung injuries in rats
Time : 10:20-10:40
Biography:
Azza El-Medany has completed her PhD at age of 32 years from Alexandria University and postdoctoral studies from Alexandria University College of Medicine. She is a Prof. of pharmacology &Vice head of department of pharmacology, College of Medicine , KSU. She published more than 40 papers in the areas of GIT, CVS, Natural products & toxicological researches in reputed journals and serving as a memberships of a number of Professional Bodies, was a speaker in a number of international conferences, the last ones in Singapore , Japan , Brazil & USA . She is a recipient of special awards in scientific research & teaching.
Abstract:
Lung fibrosis is a common side effect of the chemotherapeutic agent, bleomycin. Current evidence suggests that reactive oxygen species may play a key role in the development of lung fibrosis. The present work studied the effect of green tea extract on bleomycin–induced lung fibrosis in rats. Animals were divided into three groups: (1) Saline control group; (2) bleomycin group in which rats were injected with bleomycin (15mg/kg,i.p.) three times a week for four weeks; (3) bleomycin and green tea group in which green tea extract was given to rats (100mg/kg/day, p.o) a week prior to bleomycin and daily during bleomycin injections for 4 weeks until the end of the experiment. Bleomycin–induced pulmonary injury and lung fibrosis that was indicated by increased lung hydroxyproline content, elevated nitric oxide synthase, myeoloperoxidase (MPO), platelet activating factor (PAF), tumor necrosis factor α (TNF_α ), transforming growth factor 1β ( TGF1β ) and angiotensin converting enzyme (ACE) activity in lung tissues. On the other hand, bleomycin induced a reduction in reduced glutathione concentration (GSH). Moreover, bleomycin resulted in a severe histological changes in lung tissues revealed as lymphocytes and neutrophils infiltration, increased collagen deposition and fibrosis. Co-administration of bleomycin and green tea extract reduced bleomycin–induced lung injury as evaluated by the significant reduction in hydroxyproline content, nitric oxide synthase activity, levels of MPO, PAF & TNF-α & ACE in lung tissues. Furthermore. green tea extract ameliorated bleomycin– induced reduction in GSH concentration. Finally, histological evidences supported the ability of green tea extract to attenuate bleomycin–induced lung fibrosis and consolidation. Thus, the finding of the present study provide that green tea may serve as a novel target for potential therapeutic treatment of lung fibrosis.
Kavita Gulati
University of Delhi, India
Title: Translational research and herbal drug development: An experience with bronchial asthma
Time : 10:40-11:00
Biography:
Kavita Gulati holds a PhD and is a Professor in the Department of Pharmacology at the Vallabhbhai Patel Chest Institute, University of Delhi. She has more than 25 years teaching and research experience in basic and clinical pharmacology and herbal drugs and has been the recipient of several awards and honors for research excellence. She has more than 80 research publications, is Author of several text and reference book chapters, Co-Editor of 4 books in pharmacology.
Abstract:
Herbal drugs are emerging as viable alternatives for complex disease states and modern scientific methodology are being adopted to validate the effects of such agents used in the traditional systems of medicine. Translational research in medicine is a two-way street and aims at breaking down barriers between clinical and basic medical sciences to promote rapid transfer of knowledge from bench to bedside and vice versa. In pharmacological sciences and drug development, this concept is being utilized for accelerating the conversion of basic and/or clinical research findings to sustainable health care solutions. Bronchial asthma is a chronic inflammatory respiratory disorder with steroid dependent pharmacotherapy and the use of herbal agents is being explored in search of viable alternatives. UNIM-352 is a poly-herbal formulation, used in traditional medicine for bronchial asthma, and clinical and experimental studies were conducted to validate their observed effects. In the clinical study, UNIM-352 significantly enhanced the therapeutic effect of standard anti-asthma therapy as assessed lung function tests and symptomatology, as compared to the placebo group, indicating its efficacy as an adjunct therapy. In the experimental study, UNIM-352 demonstrated differential degrees of anti-inflammatory, immune-modulatory, broncho-relaxant, anti-remodeling, and antioxidant effects in rats, by using well established biomarkers for the above pathophysiological states. The results indicate that this poly-herbal agent could be used as an alternative/adjunct in the treatment of bronchial asthma. This study also highlights the importance of a translational approach in herbal drug research which could rationalize drug therapy of complex diseases.
Manoshi Baruah Deka
Assam Agricultural University, India
Title: Indigenous knowledge in treatment of common health problems
Time : 11:20-11:40
Biography:
Manoshi Baruah Deka is the Principal Scientist and Head, Department of Extension and Communication Management, Assam Agricultural University with 34 years of experience. She graduated from Assam Agricultural University, Jorhat and completed Doctoral studies from Punjab Agricultural University. She worked as a Technical Coordinator of Extension Education under AICRP on Home Science for 10 years, involved in planning, implementing, monitoring different research projects, compiling and reporting of data from nine AICRP centers across India. She presented invited and contributory research papers in international, national, regional seminars and conferences; and published papers in journals, chapters in books, extension bulletins. She is a Life Member of 12 professional societies.
Abstract:
The indigenous knowledge is diversified, location specific, ecologically relevant and user friendly which gets passed on from generation to generation through word of mouth. The rural people of Assam, India, are using this traditional knowledge to treat different health ailments and nurture the practices even today. Keeping this in mind a study on ‘Indigenous knowledge used in the treatment of common health problems’ was conducted in four districts of Assam namely Jorhat, Nagaon, Silchar and Kamrup. The relevant information was recorded using participatory interview, key informant interview and focused group discussion. The study revealed that Curcuma longa, Cenetella asiatica, Clitoria ternatea, Aegle marmelos, Citrus aurantifolia, Aloe vera, Leucas linifoliaetc etc are used in different forms to treat the common health problems such as wounds and cuts, inflammations, ringworm, diarrhoea, constipation, fever, cold and cough, loss of appetite, nausea, conjunctivitis, skin problems etc . Scientific validation of identified knowledge was done through study of relevant literature and discussion with experts of the line departments such as herbal medicine practitioner, Ayurvedic doctor and ethno botanist . A list of plants with their local names, pharmacognosy and pharmacological and pharmaceutical status has been reported in the present study which needs further assessment of actual ingredients.
Luiz Filipe Gonçalves de Oliveira
Laboratory of Molecular Biology and Endemic Diseases, Brazil
Title: Phytotherapy - a new and innovative perspective for leishmaniasis treatment
Time : 11:40-12:00
Biography:
Luiz Filipe Oliveira is pharmacist since 2002 and obtained his master's degree in 2010, by the National Institute of Infectious Disease of the Fundação Oswaldo Cruz in the field of clinical research in infectious diseases. Currently, he is a PhD student in Parasite Biology’s (focus on genetics and biochemistry) at the Fundação Oswaldo Cruz and is developing a research with plant extracts with antileishmanial activity, studying molecules and active fractions for the development herbal medicines and other natural product formulations.
Abstract:
Leishmaniasis is classified as one of the neglected tropical diseases, affecting mainly people in developing countries and requiring the development of novel drugs for treatment. This infection is caused by several species of the genus Leishmania, can be transmitted to humans and other mammals during the bloodmeal of phlebotomine insects and may present a large array of distinct clinical symptoms. Therefore, leishmaniases are usually classified into three main clinical categories, according to the parasite tropism: cutaneous leishmaniasis, mucocutaneous leishmaniasis and visceral leishmaniasis. The drug of choice for all clinical forms of leishmaniasis have been, for the past 60 years, the pentavalent antimonials, in spite of a large variety of adverse side effects related to its use, including cardiotoxicity. Amphotericin B and pentamidine are considered the second line of the treatment as they present even greater toxicity during treatment. In the last twenty years, the activity of medicinal plants against Leishmania spp have been widely studied and thoroughly confirmed. Among the plants proven to possess antileishmanial properties, we can cite: Kalanchoe pinnata, Plumbago scandens, Physalis angulata, Piper aduncum, Tabernaemontana (Peschiera) australis, Phyllanthus amarus, Artemisia annua and Tabeluia sp., as well as their derivate compounds. The objective of the present study is to highlight the advances in the field of research of medicinal plants and natural compounds against Leishmania spp. and, additionally, to discuss the main stages involved in technological development of drugs based on such plant. By presenting these data we reinforce the use of these medicinal plants as an innovative approach for leishmaniasis treatment and potentially for other neglected diseases as well.
Biography:
Ekwere, M.R. is a senior lecturer in the department of Chemistry, school of Sciences, Cross River State College of Education, Akampka, Nigeria and a PhD student in the department of Biochemistry, School of Basic Sciences, University of Calabar, Cross River State , Nigeria. She has a teaching and research experience in Biochemistry for 20years
Abstract:
Good nutrition prevents illness, herbal medicinal and aromatic plants are useful in treating existing health problems. Herbal medicines are not only effective but useful much cheaper alternative to synthetically produced drugs. Capsicum pepper has always been one of the most important spices with amazing healing powers since ancient time but seems to be under-rated as a natural medicine. Whatever values pepper has, as medicinal plant, is due to the essential oil and to the aromatic and pungent principle, capsaicin. This study sought to determine the oil and capsaicin content of three varieties of pepper from the genus capsicum namely, Capsicum frutescenc - bird-eye pepper and two varieties of Capsicum annum- chilli pepper and sweet pepper; relate the level of pungency and equate the essential oil to reported observed effects on human-beings. The volatile oils were extracted using soxhlet apparatus while capsaicin was extracted by a modified method of Kosugue et al, 1958. Bird-eye pepper had the highest capsaicin content followed by chilli pepper while sweet pepper had the least. Sweet pepper also had the least oil content while chilli pepper had the highest oil content followed by bird-eye pepper. No significant relationship (<0.05) existed between capsaicin and oil contents of the capsicum peppers. Thus, bird-eye and chilli peppers would best be described and used as drug capsicum.
Foluso Osunsanami Oluwagbemiga
University of Zululand, South Africa
Title: Antiplatelet aggregation and cytotoxicity activity of betulinic acid and its acetyl derivative from Melaleuca bracteates var. revolution gold
Time : 12:20-12:40
Biography:
Osunsanmi Foluso Oluwagbemiga is a senior biochemist with over fifteen years work experiences in both industrial and academic sectors. He is currently a researcher in the department of Biochemistry and microbiology, University of Zululand, South Africa. He specializes on natural product synthesis in the treatment of various diseases. He has completed his PhD works and at the edge of submitting his thesis. Notable publications have been accredited to him in reputable journals. He is a member of South Africa Association of Clinical Biochemistry and National Association of Safety professional.
Abstract:
Platelet dysfunctions are implicated in cardiovascular diseases. Management of abnormal Platelet aggregations with natural products is a promising approach to the treatment of cardiovascular diseases. In this study, betulinic acid (BA) and its acetyl derivative (3-β acetylbetulinic acid) (BAA) from Melaleuca bracteata var. revolution gold were investigated for their antiplatelet aggregation and cytotoxicity. BA was isolated from Melaleuca bracetata by column chromatography and some portion of BA were used to synthesize BAA. The antiplatelet aggregation activity of the compounds was separately evaluated on collagen, ADP, thrombin and epinephrine to induce rat platelet aggregations. The MTT cytotoxicity assay was used to determine the cytotoxic effect of the compounds against human embryonic kidney (HEK293) and hepatocellular carcinoma (HEPG2) cell lines. BA and BAA exhibited significant (p<0.05) dose dependent antiplatelet aggregation activity. BA and BAA showed the highest platelet aggregation inhibition on epinephrine induced platelet aggregation with IC50 values 0.78 mg/ml and 0.85 mg/ml respectively. BA and BAA showed less cytotoxicity effect on both HEK293 cell (IC50 1027 µg/ml and 1051 µg/ml respectively) and HEPG2 cells (IC50 448 mg/ml and 672 mg/ml respectively). The results suggest that the compounds could serve as template for synthesis of new antiplatelet drugs Platelets.
Babatunji Emmanuel Oyinloye
University of Zululand, South Africa
Title: The modulatory effect of methanol extract of Piper guineense in CCl4-induced hepatotoxicity in male rats
Time : 12:40-13:00
Biography:
Babatunji Emmanuel OYINLOYE is a Lecturer in the Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria. He has published numerous papers in reputed journals and has been serving as a review member of repute journals. He is currently rounding up his Doctoral degree in Biochemistry in the University of Zululand, South Africa. He has professional membership of Nigerian Society of Biochemistry and Molecular Biology, South African Society of Biochemistry and Molecular Biology and Society of Biology, London. Over the years, his research has centred on the evaluation and assessment of medicinal plant used in the traditional treatment of metabolic diseases, with special interest in rational drug discovery and development of nutraceuticals.
Abstract:
The aim of this study was focused on investigating the possible protective effect of Piper guineense against CCl4-induced hepatotoxicity in animal-model. Thirty male Wistar-albino rats were divided into five groups as follows: control, CCl4, pre-treatment, post-treatment and standard drug. Hepatotoxicity was induced by administering oral dose of CCl4 (1.2 g/kg bw) 3 times a week for 3 weeks. In the modulatory experiment, Piper guineense (PG), (400 mg/kg bw) was administered by oral gavage for 14 days prior to the administration of CCl4 and simultaneously with CCl4 in the pre-treatment group; PG (400 mg/kg bw) was administered simultaneously with CCl4 in the post-treatment group while Livolin forte (20 mg/kg bw) was administered simultaneously with CCl4 in the standard drug group. Administration of CCl4 induces histopathological alteration in the liver with concomitant increased activities of serum hepatic marker enzymes associated with increased level of lipid peroxidation. Similarly, there was decrease in non-enzymatic (reduced glutathione; GSH) and enzymatic antioxidants (glutathione S-transferase; GST), superoxide dismutase (SOD) and catalase; CAT). Elevation in serum triglyceride (TG) and total cholesterol (TC) levels was noticed along with decreased level of serum total protein (TP). Treatment with PG 400 mg/kg bw exhibited excellent modulatory activity with respect to the different parameters studied by reversing all the above-mentioned biochemical changes significantly in all experimental animals. These results suggest that PG offered protection comparable to that of Livolin forte with better efficacy when pre-treated with 400 mg/kg bw 14 days prior to CCl4-exposure.
Mohammad Zashim Uddin
University of Dhaka, Bangladesh
Title: Ethnomedicinal study and consensus among the informants for the uses of medicinal plants of feni
Time : 14:00-14:20
Biography:
Mohammad Zashim Uddin obtained Ph. D. at the age of 32 years and trained from USA on tropical biodiversity. His current position is Professor in the University of Dhaka and supervised 25 M.S. research students and presently guiding one Ph. D student. By this time, he published 56 research articles in different scientific journals. Recipient of numerous awards and grants, Dr. Zashim has participated at least 41 events of training program/ workshop/ international conference. He served as biodiversity expert in 20 research projects here in Bangladesh. His current research focuses are on threatened ethnomedicinal plants and conservation of forest biodiversity.
Abstract:
Ethno-medicinal study was conducted to identify and document plant species used for treatment of various ailments and to find out the level of consensus among informants regarding the uses of plants for particular disease categories. Information has been gathered between January to December 2014 from 65 informants using semi-structured interviews. The reported plants were collected, identified and preserved. The study was recorded115 medicinal plant species with 216 formularies to treat 69 ailments. These species belongs to 55 families. Such data indicated that the study area has plenty of medicinal plants with their diversity of health care uses. Ailment category cut and wounds attained the highest Fic value. Species used for this purpose are Mikania cordata, and Cynodon dactylon which were cited by many informants. Second highest Fic value was found in case of Dysentery and diarrhoea. Medicinal plants used for this purpose are Litsea glutinosa, Dalbergia sissu, Mangifera indica, Scoparia dulcis, Holarrhena antidysenterica, Stephania harnandifolia and Centella asiatica those were cited by a good number of informants. Since the Fic values attained highest, such plants could be recommended for further phytochemical study to isolate compounds. In our survey, 16 species has attained 100% Fl values. This Fl values means that the informants have a tendency to rely on one specific plant species for treating one certain ailment than several ailments. The study asserted that such species need to be protected in the study area to sustain traditional medicinal plants and culture.
Nguyen Thi Trieu
Physician, Vietnam
Title: Tenofovir Disoproxil Fumarat , Herbal Medicaments, Vitamin C Treatment on HBeAg Positive or HBeAg Negative in Chronic Hepatitis B (HBV)
Time : 14:20-14:40
Biography:
Physicians Trần Minh Äức & Nguyá»…n Thị Triệu from Vietnam, they are pursuing a combination of natural herbal and medicinal artificially to create a new breakthrough towards helping improve the quality of life. They are rediscovering nature and nurture as safer in treatment, cost effective health and healing resources
Abstract:
Phyllanthus Cantoniensis Hornem - Herba Adenosmatis Caerulei - Herba Eclipta - Vitamin C combination plus Tenofovir in treatment of acute and chronic hepatitis B. Method the combination of drugs derived from natural and artificial medicaments. Has stronger effect on immune system, effective good against HBV replication. This is a substantial new insight into the pathogenesis of disease, with a clear path toward clinical application, or which would lead to a substantial advance and perfect in management or public health policy. Triple
Benjamin Opawale
Rufus Giwa Polytechnic, Nigeria
Title: Evaluation of antimicrobial, antioxidant and cytotoxic activity of lovoa trichiliodes extracts and essential oils
Time : 14:40-15:00
Biography:
Benjamin Opawale is a Ph.D. student at the Microbiology department of Federal University of Technology, Akure, Nigeria. He lectures at the Department of Science Laboratory Technology, Rufus Giwa Polytechnic, Owo, Nigeria, and has served at various academic and administrative positions positively in the last twenty years. He currently holds the position of Dean of students in the institution. His recent research interest is in the area of medicinal plants used as folkloric remedies and has published more than 15 papers in reputable Journals. He is a member of Nigerian Institute of Science Laboratory Technology and American Society for Microbiology respectively. He is happily married with children.
Abstract:
Evaluation of Antimicrobial, Antioxidant and Cytotoxic Activity of Lovoa trichiliodes Extracts and Essential Oils: Lovoa trichiliodes is a medicinal plant used in many African countries by traditional practitioners for the treatment of some infectious diseases. The extracts and essential oils of Lovoa trichiliodes were investigated for their antioxidant, antimicrobial and cytotoxic properties using standard techniques. The DPPH scavenging activities ranged from 05.33±0.88% at 0.05mg/ml of leaf to 88.14±0.03% at 2.0mg/ml of stem bark essential oils respectively. The IC50 of the stem bark oil (0.81±0.15) and that of the leaf oil (1.52±0.03) were significantly (p≤0.05) higher than that of ascorbic acid (0.40±0.15) used as control. The antimicrobial assay of the samples revealed a high activity against the test pathogens at 50mg/ml for extracts and 50µg/ml for oil respectively. The leaf extract showed lower level of activity than the stem bark extract against the test organisms compared to the controls. The essential oils from both the leaf and stem bark exhibited higher activities against bacteria than fungi. Bacillus subtilis showed the highest susceptibility to the extracts while Pseudomonas aeruginosa exhibited the least susceptibility to the plant materials. The minimum inhibitory concentration and minimum bactericidal/fungicidal concentration ranged from 2.5 to >200mg/ml and 5 to 200mg/ml for the extracts while that of oils ranged from 3 to 40µg/ml and 5 to 75µg/ml respectively. However, water extract of the plant’s stem bark showed no activity against any of the test organisms. All the extracts and essential oils showed high level of lethality on brine shrimp larva with LC50 ranging from 0.71 to 56.13ppm. These results confirm the basis for the use of this plant in traditional medicine as remedy against several diseases.
Adewale Adetutu
Ladoke Akintola University of Technology, Nigeria
Title: Anti-malaria Activities of Selected Plants and Gas Chromatography-Mass Spectrometer Chemical Profiling of Aqueous Bark Extract of Prosopis africana (Guill &Perr)
Biography:
Adewale Adetutu studied PhD, MSc and BSc in Biochemistry at University of East London, London, United Kingdom and University of Ibadan, Nigeria, respectively. He is currently researching at Ladoke Akintola University of Technology Ogbomoso, Nigeria.
Abstract:
Background: The development of resistance to currently known conventional anti-malaria drugs has necessitated search into more potent and less toxic anti-malaria drugs of plant origin. Objective: Hence, this study aimed to document plants commonly used to treat malaria in Ilorin metropolis, Nigeria and validate the traditional claims using in vivo anti-plasmodial tests. Methods: Semi-structured questionnaires (70) were used to explore the ethno-botanical practices amongst the traditional healers. The most common species cited were identified, authenticated and their aqueous extracts were screened for antimalarial activities using Plasmodium berghei (NK 65 chloroquine sensitive) and chloroquine as the malarial parasite and positive control respectively. For in vivo anti-plasmodial testing, the mice were infected with 1×107 parasitized erythrocytes and plant extracts were subsequently administered orally for suppressive, prophylaxis and curative assays. Percentage parasitemia was estimated by standard microscopy and haematological parameters were also measured using standard analyser. Results: Seventy traditional healers from Ilorin metropolis, Nigeria were involved in the study. Forty-three species were recorded with their local names and parts used in the traditional therapeutic preparations. Ten plants with highest frequency of citation (Cymbopogon citrates (17.1%), Azadirachta indica (12.9%), Prosopis africana (12.9%), Vernonia amygdalina (11.4%), Khaya grandifoliola (10%), Terminalia glaucescens (10%), Ziniber officeinale (7.1%), Citrus paradise (7.1%), Parquetina nigrescens (7.1%), Psidium guajava (7.1%),) were selected and investigated for anti-malaria activities. The aqueous extracts of all the selected plants showed significant (p<0.05) anti-malaria activities. P. africana bark extract at 200 mg/kg body weight had the highest chemo-suppressive effect (90.02%) in comparison with other plant extracts and the standard, chloroquine (61.70%) on the 8th day. In addition, the maximum Mean Survival Time (MST) of 23 days was observed in animals administered with P. africana and chloroquine. The extract of P. africana was further analysed for possible bioactive components using Gas Chromatography-Mass Spectrometer (GC-MS). The GC-MS analysis revealed that the aqueous bark extract of P. africana contained lipid (eight), phytochemical (sixteen) and essential oil (eighteen) components. The histological analysis of the liver revealed that the extract of P. africana was able to protect the liver against B. bergei induced damages. Conclusion: Most of the species tested had some antiplasmodial effects, which to some extent supports their traditional inclusion in herbal preparations for treatment of malaria. The bioactive components identified may be responsible for the observed antimalarial activity of P. Africana extract.
Remirez Figueredo Diadelis
Reviewer at the Cuba Regulatory Agency, Cuba
Title: Regulatory frame work and quality control of medicinal plants.
Time : 03:00-03:20
Biography:
D. Figueredo received her B.A. degree (1995, Biochemistry) from Faculty of Biology, Havana University, Cuba, and both her MSc (1995, Biomedicine) and PhD (1999 Pharmaceutical Sciences) degree from National Center for Scientific Research in Havana, and most of the results were done in the Department of Toxicology at the Free University in Amsterdam. Postdoctoral training in Molecular Toxicology and pharmacology was completed at the Faculty of Pharmacy in Toronto, Canada. She has been referee of scientific journals related with natural products. Other previous academic appointments include lecturer in different international meeting. She has been the recipient of National Award of Pharmacology twice from the Cuban Pharmacology Society. She worked as Expert for the evaluation of preclinical platform in South Africa. (CSIR). She is currently the Vice president of Cuban Pharmacology Society. She is the WHO focal point for traditional medicine in Cuba. At present she works in the Cuba Regulatory Agency, she is one of the reviewers for authorization of clinical trials, and the evaluation of safety and efficacy of drugs (synthetic and natural products) for registering. She is the project leader for Pharmacogenetic guideline. Dr. Remirez research is described in over 30 published research reports
Abstract:
In the last decade there has been a global upsurge in the use of traditional medicine and complementary and alternative medicine in both developed and developing countries. This is one of the main reasons for reinforcing the surveillance of the safety, efficacy and quality control of traditional medicine, complementary and alternative medicines. This work describes important aspects about the art state of the regulatory status of herbal medicines. Besides that, data related with the countries involved in the World Health Organization (WHO) program for traditional medicine will be showed. Another important aspect is, the importance of clinical trials in order to guarantee the safety, quality and efficacy of Natural Health Product, the main mistakes in Clinical Trials of natural products are explained. The market and the main challenges are analysed in the investigation of the phytomedicines as well as the tendencies in the growth of this attractive sector. The WHO strategy for the development of herbal medicinal product is also showed. The regulatory framework of traditional medicine in Cuba will be presented as well as the implementation of WHO strategy. In conclusion, Drug Regulatory Authorities should ensure the quality, safety and efficacy of traditional medicines.
Biography:
Ian Feguson Hamilton has been teaching and in homeopathic practice since 1989 with successful practices in all parts of the UK. He was editor of The Homeopath for nearly 5 years and is the Founder of the Art and Homeopathy Group.
Abstract:
A homeopath, to be able to perceive this totality of symptoms, has to be patient, gentle, tolerant and forbearing and this is where art comes in. He must observe and perceive more particularly, the symptoms that the patient unknowingly tries to conceal, because he cannot relate or has no knowledge of how homeopathy works. Altered states like actions, sensations, emotions, behaviors and feelings that the patient would not normally have in healthy state, are the true evidence of diseaseâ€. Samuel Hahnemann, Organon of the Medical Art My work with a variety of patients and working with members of the group has shown that, in addition to the accepted methods of case taking and anamnesis, the focus on the patients’ artistic expression reveals the altered states as evidence of disease, which Hahnemann refers to. This is based on the notion that most case taking produces what I refer to as the Archetypal state. This is often the basis of a partially curative prescription. The truly curative prescription arises from the deep hidden language of expression – their passion - which the patient often unknowingly conceals. I will be presenting illustrative cases as evidence of this remarkable thesis, showing true deep healing of a variety of physical and emotional disorders, in a series of follow ups. A variety of artistic expressions will be evident as the range of the method.
Carla Rose Kelly
Healer at Sacred Scale, Canada
Title: Sacred scale for healing, ascension & improvisation
Biography:
Carla Rose Kelly, life-long musician, multi-instrumentalist, award winning pianist, composer, recording artist, Master Healer with Music, has 3 post-secondary degrees, Royal Conservatory piano & theory teacher 25 years, 10 years vocalist with Conservatory Canada. Carla Rose is inventor of Sacred Scale musical instruments and Sacred Scale Music Education Program and is pioneer and sole researcher in the world of the healing effects of Sacred Scale. She facilitates internationally at the IAMM, ISQRMM and Music Therapy Conferences sharing the substantial results of her quantitative research. This work is published in the 2014 ISQRMM Journal. Carla Rose teaches in Japan, Australia, Canada and US. Her passion is healing with music.
Abstract:
The Sacred Scale is a new musical scale specially designed on Sacred Scale Musical Instruments. It is 9 specific frequencies all in tune with the laws of nature, all in tune with the human body. These innovative musical instruments are specifically designed for healing, ascension or improvisation. An introduction to the methodology for using the Sacred Scale for healing, ascension and improvisation will be presented. As well, participants will be offered a sample Sacred Scale session to experience what happens in the mind, body and soul from exposure to the music. Discussion and question period will follow. Participants will receive a handout explaining the study results as well as the history of the Sacred Scale.
Hans Schaeffler
Institute for Ayurveda, Austria
Title: The art of healing in Ayurveda compared with the traditional healing methods of the Maori from NLZ
Biography:
Hans Schaeffler studied human medicine in Munich. He is a general practitioner, educated in Naturopathy and a specialist in ayurvedic medicine. As early as 1984 he founded the first Ayurveda Health Center in Germany. In 1993 he moved to Austria and founded an Ayurvedic Health Center in the 5 Star Hotel Schloss Pichlarn. His activities in lecturing and publishing articles and papers helped to make Ayurveda popular in German speaking countries. He is a meditation teacher and in addition to Ayurveda he also studied other traditional methods of healing.
Abstract:
Ayurveda is normally known as a set of text-books displaying the approach to diagnosis and treatment of the ancient Indian civilization. But the origin and the heart of Ayurveda is not found in books. It is the inner connection with the field of healing, the field of pure energy. This universal field of healing unfolds itself in terms of five elements these elements can be considered as threshold forces which connect the realm of energy with the expressed world. We have to assume that the founding fathers of Ayurveda, living as Rishis (recluse) in the depths of the forests, experienced the elements as animated. In this way they could contact the elemental forces for the purpose of healing. Evidence for this idea is found in the Veda. Many hymns of the Veda are invocations of elemental forces. Interesting enough, we find a similar approach in the tradition of indigenous people who practice the connection with the forces of nature to the present day. Against this background it is interesting to see, that Ayurveda in its essence has a similar basis as the traditional healing methods of the Maori.
Mindy Green
Western Herbalist, Aromatherapy, Esthetician, USA
Title: Aromatic medicines in integrative care
Biography:
Mindy Green has 35 years of experience in the botanicals industry. She is a nationally certified Registered Aromatherapist and has served on the education committees of the National Association of Holistic Aromatherapists and the Aromatherapy Registration Council. Mindy has authored three books and over 60 published articles on botanical therapies and health. An active educator and lecturer, Mindy is an ongoing presenter at the Center for Integrative Medicine at the University of Arizona. As a consultant and speaker she specializes in botanical therapies and value-added aromatherapy. She is a founding and professional member of the American Herbalists Guild, a graduate of Purdue University’s Advanced Uses of Essential Oils program, and is on the advisory board for the American Botanical Council, publisher of HerbalGram magazine. Mindy worked in the botanical research division of Aveda’s R & D department as their clinical aromatherapist (2003 – 2009). Her consulting company is Green Scentsations, LLC.
Abstract:
Aromatic plants (herbs and essential oils) have been used throughout history for healing, whether through pharmacy, cosmetic care, or spiritual practices. Modern science confirms that the chemical constituents found in essential oils have tremendous benefits, and are being used in medical systems abroad with wide ranging therapies from primary to palliative care, while the US falls behind in this innovative and science based modality. This lecture will focus on essential oil safety, dilution, application, and external uses. We will discuss the implications of olfaction in de-stressing, and provide material medica for ten functional essences derived from plants. Seeing the research and examples of how the rest of the world is employing them in integrative care is sure to provide a more thorough understanding of their benefits and the confidence to incorporate them safely and effectively into your personal life and professional practice.
Michael D. Seidman
Henry Ford Health System, USA
Title: Complementary and Integrative Medicine (CIM)
Biography:
Michael D. Seidman, MD attained both his B.S. in Human Nutrition and M.D. from the University of Michigan. After a five-year residency in Otolaryngology-Head and Neck Surgery at Henry Ford Health System (HFHS) he completed a fellowship in Otologic/Neurotologic and Skull Base Surgery at the Ear Research Foundation in Florida. Seidman is the Director-Division of Otologic/Neurotologic Surgery in the Department of Otolaryngology-Head and Neck Surgery for HFHS, Past Director of Otolaryngology Research Laboratory, the Co-Director of the Tinnitus Center, the Chair of the Center for Integrative Medicine for HFHS, Director of Product Development (nutritional science/projects) for ViSalus Sciences, a past President of the Michigan Otolaryngology Society, and was elected in 2009 to be the next Chair of the Board of Governors for the American Academy of Otolaryngology Head and Neck Surgery. has more than 80 major publications; a book published by Time Warner “Save Your Hearing Now†numerous awards including being honored as one of the top Doctors in the USA. He has been interviewed on Good Morning America, CNN and other national news venues and has been quoted nationally and internationally in such magazines as “Oâ€, “Shapeâ€, Women’s World, Men’s Health, The Wall Street Journal, New York and the London Times Seidman is also a Co-Editor for the International Tinnitus Journal, the Associate Editor for Otolaryngology-Head and Neck Surgery journal and is on the Editorial Review Board for seven major Otolaryngology Journals and the American Journal of Chinese Medicine
Abstract:
Our existing paradigm of “health care†is nothing more than “sick careâ€. Providing a more holistic and preventive approach is challenging but something we must implement. The CDC estimates that 2/3rds to 3/4ths of all medical disorders are preventable. In 2013 “sick care†spending is estimated to approach 2.7 trillion dollars and consume 18% of the gross domestic product. This is unsustainable, and an approach that we have implemented at Henry Ford Health System; our wellness initiatives are designed to target many health care issues with the goal of preventing disease, improve outcomes and reduce health care expenditures. Some of these strategies involve Complementary and Integrative Medicine (CIM). “The best care is likely to emerge from a skillful blend of best evidence with caring, humility, and behavior that engenders a placebo response"(Rich Rosenfeld). The power of the body to heal itself is grossly underutilized in medicine today; the best physicians understand this and find ways to facilitate this healing. Physicians must learn about CIM. This course will provide the attendee with an important understanding of the powers of CIM; the pro’s the con’s what is safe and effective and how to appropriately offer these techniques to our patients.
Adama Ly
Université Paris XI and Afrocancer, France
Title: Cancer and alternative therapies in Africa
Biography:
Adama Ly is the President - Founder of AFROCANCER and Editor in Chief of the revue “Journal African du Cancer / African Journal of Cancer†published by Springer. Doctor in Immunology and Oncology at University Paris XI (Villejuif, France). He received a Master 2 in Biomedical Engineering and Innovations Management (Pierre and Marie Curie University, Paris, France). He is a visiting fellow at Sydney Kimmel Cancer Center, San Diego, USA) and at Martin Luther Wittenberg University (Halle, Germany). He is Member of many professional societies and scientific boards; he has published several articles and books in antitumor AL immunity and cancer cellular therapies.
Abstract:
Cancer is a leading cause of death worldwide. The spread of the disease impacts less developed countries that endure a large part of the burden. Infrastructures, human resources and affordable medicines are crucial needs to tackle the inevitability of death by cancer in Sub-Saharan populations. Herbal medicines and natural products remain alternative therapeutics. As a matter of fact, health professionals must explore these natural drugs with traditional healers help to secure and control the self-medication. In the meantime, it’s the best way to exploiting the traditional knowledge for new drugs discovery and to enhance the African capacities in drug screening. This scientific and sociologic approach will be presented
Olugbenga Morebise
All Saints University School of Medicine, Dominica
Title: Dominican medicinal plants—uses, chemical constituents, bioactivity reports and prospects
Biography:
Olugbenga Morebise obtained a PhD degree in Biochemistry from the University of Ibadan, Ibadan, Nigeria. He has been involved in both teaching and research in Nigeria before moving to the Caribbean. He currently teaches Biochemistry at the All Saints University School of Medicine, Roseau, Dominica. He has done research work on bioactivities of medicinal plants, including anti-inflammatory, analgesic, antimicrobial, anti-diabetic and allelopathic activities. He has published many articles in reputable journals. He currently hopes to team up with his colleagues to establish a phytochemical/ herbal research unit in Dominica.
Abstract:
The Commonwealth of Dominica is blessed with a lot of green plants, many of which are used for medicinal purposes, including treatments for coughs, asthma, bronchitis, tuberculosis, sore throat, diabetes mellitus, hypertension, fevers, erectile dysfunction, skin disorders, cancers, indigestion, dysentery, dysmenorrhea, worm infestation, obesity, vomiting and a host of other disorders. Bush tea is a common term in Dominica and it refers to the decoction, concoction or infusion made from the medicinal plants. This presentation shows how the popular medicinal plants are usually used by the locals in Dominica and their strong folkloric beliefs on the efficacies of the herbals. The chemical composition of the plants and bioactivity reports on them, based on research finding from different parts of the world, are also presented in this report. Some of the plants still have few or no phytochemical and bioactivity reports on them, indicating ideal areas for novel researches. Future prospects and recommendations in the areas of novel herbal formulations, drug discovery and medicinal plant research in Dominica are also highlighted.
Sherif R. Abdel-Aal
National Organization for Drug Control and Research, Egypt
Title: Phytochemical study and biological activity of leaves and flowers of ipomoea carnea j. grown in egypt
Biography:
Sherif Reda Abdel-All Ali has completed his B.SC.in Pharmaceutical sciences at the age of 22 years from October 6 University and registered for master degree in Pharmacognosy at Faculty of Pharmacy Helwan University. At present he is working as a drug quality control specialist at phytochemistry laboratory (Medicinal Plant and Herbal Drugs department) at National Organization for Drug Control and Research (NODCAR EGYPT).
Abstract:
Ipomoea carnea was recorded along canals, drains, road sides, railways, waste lands and fluid edges in the Nile Delta. GC/MS was used for qualitative and quantitative analyses of lipoidal content of the leaves and flowers of I. carnea. 32 Components representing 83.548 % were identified in the fatty acid methyl esters of the leaves of I. carnea while 23 components representing 84.424 % were identified in the fatty acid methyl esters of the flowers. On the other hand, 22 components were identified in the unsaponifiable matter of the leaves representing 83.398 %, while 25 components were identified in the unsaponifiable matter of the flowers representing 91.069 %. HPLC was used for assay of rutin in leaves and flowers ethanol extract of I. carnea. The leaves ethanol extract showed higher concentration of rutin (8.85 mg/g dry wt) than flower ethanol extract (2.72 mg/g dry wt). The total phenolic compounds, the in-vitro and in-vivo antioxidant properties and the antimicrobial activity against gram-positive and gram-negative bacteria, fungi and their minimum inhibitory concentration (MIC) were evaluated. The results showed that the ethanol extract of flower contained higher phenolic compounds than ethanol extract of leaves (9.331and 6.6348 mg (GAE)/g dry wt, respectively). The ethanol extract of leaves possessed higher DPPH radical scavenging activity than ethanol extract of flowers (IC50 = 1.608 and 4.861 mg/ml respectively). The flowers ethanol extract showed higher antibacterial activity in comparison with gentamicin and ampicillin against Eschirechia coli, Streptococcus pneumonia and Bacillis subtilis with MIC values (3.9 µg/ ml, 3.9µg/ ml and 0.98 µg/ ml) respectively. The leaves ethanol extract showed mild potent antifungal activity compared with amphotericin B against Aspergillus fumigatus with MIC value (7.81 µg/ ml). The extracts were tested for cytotoxic activity against liver, breast and colon carcinoma cell lines; leaves extract showed potent cytotoxic activity against breast carcinoma cell lines (IC50=7.4 µg/ml) while it showed mild cytotoxic effect on liver and colon carcinoma cell lines (IC50=23 and 35 µg/ml respectively) comparing to doxorubicin while the flower extract showed only cytotoxic activity against breast carcinoma cell lines (IC50=44.2 µg/ml).
Tonyelle R. Russell
President at International Naturopathic Medical Association, USA
Title: A comparison of the anti-Staphylococcus aureus activity of extracts from commonly used medicinal plants
Biography:
Tonyelle R. Russell is a Naturopathic Medical Doctor: President of the International Naturopathic Medical Association.
Abstract:
Resurgences of Staphylococcus aureus infection continue globally, with antibiotic resistance increasing dramatically, making these infections more difficult to treat. S. aureus epidemics impose public health threats and economic burdens on health care costs worldwide, presenting challenges modern medicine struggles to control. In order to answer today's call for effective treatments against S. aureus, we evaluated and compared various botanical extracts that have historically been suggested as useful for their antimicrobial properties against S. aureus. Briefly, S. aureus cultures were treated with selected botanical extracts and the minimum inhibitory concentration (MIC) determined. In addition, to obtain more quantitative measures on bacterial growth, 24-hour growth studies were done to examine the temporal activity and stability of various botanicals on bacterial replication. The antimicrobial activity observed for the botanical extracts used in this comparative evaluation of efficacy included both bacteriostatic and bacteriocidal activity against S. aureus. Highly effective botanicals including Salvia officinalis, Eucalyptus globulus, Coleus forskohlii, Coptis chinensis, Turnera diffusa, and Larrea tridentata exhibited MIC values ranging from 60 to 300 μg/mL and a 10(6)-fold reduction in bacterial replication. Arctostaphylos uva-ursi and Allium sativum were slightly less effective, exhibiting MIC values ranging from 90 to 400 μg/mL and a 10(5)-fold reduction, while Anemopsis californica gave MIC value of 360 μg/mL and a 10(4)-fold reduction in bacterial replication. Many botanicals, especially at lower doses, had an initial inhibitory effect followed by a recovery in bacterial replication. Such botanicals included E. globulus, C. chinensis, T. diffusa, A. californica, and Berberis vulgaris.Our data demonstrate that S. officinalis, E. globulus, C. forskohlii, A. uva-ursi, C. chinensis, T. diffusa, A. californica, A. sativum, and L. tridentata all show promising direct antimicrobial activity against S. aureus. For many of these botanicals, strong bacteriocidal activity was observed at higher concentrations, but even at lower concentrations, bacteriostatic activity was evident. Other botanicals including B. vulgaris, Baptisia tinctoria, and Glycyrrhiza glabra showed moderate activity against S. aureus, while Schisandra chinensis, Echinacea angustifolia, and Polygonum multiflorum were shown to be ineffective.
Jade Hatfield
National College of Natural Medicine, USA
Title: The treatment of Lyme disease using botanical medicine and essential oil extracts
Biography:
Jade Hatfield is a recent graduate from the National College of Natural Medicine in Portland, Oregon. She received her Doctorates in Naturopathic Medicine, as well as a Masters of Science in Integrative Medical Research. She had spent the past 10 years researching integrative plant therapies in the treatment of Chronic Lyme disease and its residing co-infections.
Abstract:
Borellia burgdorfi, a spirochete microorganism, is the infectious agent of Lyme disease, the number one growing insect vector disease in the United States. B.burgdorfi, when transmitted into the human host via a tick, also travels with many other co-infections. Current research shows there are five common co-infections that are transmitted alongside B.burgdorfi; Babesia, Erhlicia, Mycoplasmas, and Anaplasmas. The treatments of Lyme disease and co-infections have shown growing results using botanical medicine, as well as essential oils. When an organism attaches itself to the cell receptor of a normally healthy cell, it signals the releases a cytokines, important for intercellular communications in the body. The cytokine is a signal telling the immune system what is happening and what that cell needs. The immune system responds sending specific cells to that part of the body. The co-infections and B.burgderfori utilize this process to enable their successful infection of the body. Instead of waiting for the immune system to respond to them, they do it as soon as they enter the blood of the host, facilitating its spread throughout the body and sequestration inside the human cells. When understanding the invasion of the immune system via these microorganisms, botanical medicine can be used to modulate the damage, weakening the microbes, increasing the immune system and in turn creating an environment within the body that the organisms can no longer survive.
Hemant Sood
Jaypee University of Information Technology, India
Title: Production of high value medicinal herbs raw material as an enterprise among high altitude communities of north-western himalayas
Biography:
Hemant Sood has done PhD on Medicinal Plant Biotechnology in 2009 from the Jaypee University of Information Technology, Waknaghat, Solan, INDIA and joined as a faculty at the same University in 2009. She has been awarded a prestigious Young Scientist Award of the INDIAN SCIENCE CONGRESS ASSOCIATION Conferred by Nobel Laureate Prof. Venkatraman Ramakrishnan, in 2012 on her contributions in developing cell culture technologies for high altitude medicinal herbs. She has published in journals of repute and has presented papers in prestigious international conferences some of which have been awarded as best poster awards. She has filed/published 6 patents on her research outcome. Her research on medicinal herbs has been funded by various funding agencies such as DBT, DST, DRDO, and MEF of the Govt. of India.
Abstract:
The Indian Himalayan Region (IHR) covering approximately 4, 19,873 km2 areas, supports natural, unique and socio-economically important floristic diversity due to unique topography, diverse habitats and large altitudinal range (200-8,000m amsl). Among several medicinal herbs, the four species, Swertia chirayiata, Dactylorhiza hatagirea, Gentiana kurrooa and Picrorhiza kurrooa have been extensively used in the preparation of various herbal drug formulations. Due to over exploitation and habitat degradation, the populations of these medicinal herbs are depleting at an unprecedented rate and as a result have been declared as endangered. The imposition of legal restrictions on the collection of raw material from natural habitats has caused not only economic constraints on the local communities but also resulted in shortage of quality raw material for pharmaceutical and herbal drug industries. This has led to illegal procurement and adulteration of raw material of medicinal herbs, not only affecting the livelihood of local farmers but also resulting in adulteration of herbal drugs. We have developed tissue culture technologies for large-scale production of quality planting material for these herbs. The plant material is checked for the desired amounts of marker compounds and genetic purity through molecular markers before transferred to local communities for transplantation and adoption of technologies. The production of quality plant material is expected to go a long way in not only reclaiming the natural habitats of medicinal herbs but also creating avenues for enterprise development in high altitudes of Himalayas.
Kishan C. Gupta
Anand College of pharmacy, India
Title: Therapeutic applications of essential oils and their constituents
Biography:
Former Director Anand College of Pharmacy, Keetham Agra (UP) India, Professor & Head, G.B.P.U.A.T, Pantnagar,Uttrakhand
Abstract:
Essential oils are odorless, highly volatile, secondary metabolites widely recognized as green therapeutic medicaments for treatment of different ailments. They are known for their therapeutic properties as antibacterial agents against a wide spectrum of pathogenic strains due to the presence of Phenolic components such as Thymol, Carvacrol, Eugenol, etc. which inhibits gram positive pathogenic bacteria more than gram negative pathogenic bacteria. Essential oils also show bactericidal like activity against oral and dental pathogens, used for treatment of herpes infections. Garlic oil showed hypo lipidemic action. Beside these essential oils have also been screened for hypotensive anti diabetic, anti-cancer, antioxidants as well as for cardiovascular, menopausal, skin disorders, leukemia and hepatic disorders.
Shagufta Perveen
King Saud University, Saudi Arabia
Title: Natural remedies from saudi herbs for treatment of certain serious health problems
Biography:
Shagufta has completed her Ph.D. at the age of 28 years from HEJ Research Institute of Chemistry, University of Karachi, Pakistan and University of Southampton UK, School of Chemistry. She is an Associate Professor at Department of Pharmacognosy, College of Pharmacy, King Saud University, Saudi Arabia. She has published more than 50 papers in reputed journals and has been serving as an editorial board member of many scientific journals.
Abstract:
Cancers figure among the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases and 8.2 million cancer related deaths in 2012. The deaths from cancer are projected to continuously rise worldwide, with an estimated 13.1 million deaths in 2013. Lung cancer is the second most common cancer in men, the colon and rectum cancers in combination rank third in frequency among males in the United States. Anticancer drugs are used to target all rapidly proliferating cancer cells. Chemotherapy is one of the most important therapeutic options used to treat human cancers, either alone or in combination with radiation therapy and surgery. Although a number of new anti-cancer drugs that target various key processes in cancer progression have been developed, but overall patient survival rates have mostly remained unchanged for a number of years. Hence, the use of natural products has now been looked upon thoughtfully in the control of cancer. Plant derived natural products have received considerable attention in recent years due to the presence of various bioactive compounds and their diverse pharmacological properties including cytotoxic and cancer preventive effects. Among the common fungal infections that affect women in Saudi Arabia, is yeast vaginitis. Research results indicated that 59.6% of yeast vaginitis in women from Saudi Arabia is caused by C. albicans, and 31.6% by C. glabrata. Nowadays, such infections are becoming more drug resistant, hence it would be of much importance to explore new antifungal drugs of natural origin and introduce them to the pharmaceutical industry. The aim of our work is to contribute to the knowledge of the chemical composition of Saudi medicinal flora and validate its ethnomedicinal use, trying to find a scientific justification for the traditional use of these plants. In conclusion, this study led the way to the preparation of safe and efficient herbal drugs that can be used to treat different types of cancers as well as certain fungal infections.