Day 2 :
- Herbal Medicine| Medicinal Plants | Alternative Medicine
Bandar H Aloufi
University of Hail, Saudi Arabia
Title: Evaluation of omega-3 on lipid profile and biochemical parameters on Wistar rats
Bandar H Aloufi is a Professor at the Department is Biology, University of Hail in Saudi Arabia.
The lipid profile (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides) is used as part of a cardiac disease risk assessment. In this research, we investigate the efficiency of Fish oil to decrease the levels of total cholesterol and proteins in Wistar rats (n=60) weighing (225-250 g). Fish oil was fed for seven weeks to Wistar rats. Hematological and physiological parameters were examined by automatic analyzer and the results were statistically analyzed by SPSS.12. In comparison to control rats showed highly significant decrease in values of following physiological parameters; triglycerides, total cholesterol, low density lipoprotein cholesterol, total protein, and in contrast, marked increase in the value of high density lipoprotein cholesterol. These findings indicate that diets containing fish oil significantly improved the physiological parameters of rats. We suggest that fish oil as part of food might improve blood parameters and increase high density lipoprotein cholesterol in rats. We further suggest that fish oil supplementation act as antioxidant agents and an excellent adjuvant therapy for rats.
Fanfan Zhou has obtained her PhD from Rutgers, the State University of New Jersey, USA in 2008. She is currently a Senior Lecturer in the School of Pharmacy, the University of Sydney, Australia. She has published more than 70 papers in reputed journals since 2003. She is an Editorial Board Member of two international journals and serves as Reviewer to many prestigious journals.
The Retinal Pigmented Epithelium (RPE) is a monolayer of cells located near the choroidal capillaries that mediates human visual cycle and nourishes other retinal cells. It is known that hypoxia-induced oxidative stress to RPE is a vital cause of many neo-vascular retinal diseases such as the Age-related Macular Degeneration and Diabetic Retinopathy. The therapeutic outcome of these diseases is often disappointing; therefore, it is clinically important to protect RPE cells from hypoxia assault. Betulinic Acid (BA) is a penta-cyclic tri-terpenoid with anti-oxidative property, but little is known about its effect on retinal cells. Our study investigated the protective effect of BA and its derivatives against cobalt chloride-induced hypoxia assault in human RPE cells. Human ARPE-19 cells were exposed to BA and its nineteen derivatives (named as H2-H20) that we customized through replacing moieties at C3 and C17 positions. We found that cobalt chloride reduced cell viability, increased ROS production as well as induced apoptosis and necrosis in ARPE-19 cells. Interestingly, the pretreatment of H7 compound effectively protected cells from acute hypoxia assault caused by cobalt chloride. Our immune-blotting results showed that H7 attenuated the cobalt chloride-induced phosphorylation of Akt, Erk and JNK pathways. All findings were further validated in human primary RPE cells. In summary, the BA derivate H7 has protective effect against the acute hypoxic assault in human RPE cells and may be developed into a candidate agent effective in the prevention of prevalent retinal diseases.
Nanjing University School of Medicine, China
Title: The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-κB/IL-6/STAT3 signaling in hepatocellular carcinoma
Jiwu Wei has completed his MD and Postdoctoral studies from Ulm University and Munich University School of Medicine, respectively. He is the Professor of
Nanjing University School of Medicine, China and a Principle Investigator in Cancer Biological Therapy. He has published more than 25 papers in reputed journals.
The NF-κB/IL-6/STAT3 inflammatory axis is highly activated in a variety of inflammation-related cancers and contributes to suppression of antitumor immunity. In this study, we generated a novel herbal formula NHE-06, a water-decocting extract from six natural herbals, Ficus carica, Taraxacum mongolicum, Angelica sinensis, Lonicera japonica, Pseudo-ginseng and Folium ginkgo. We investigated the anti-inflammatory properties of NHE-06 and its antitumor efficacy in hepatocellular carcinoma, a typical inflammation-related cancer. We found that NHE-06 effectively suppressed NF-κB/IL-6/STAT3 signaling and enhanced antitumor immunity both in vitro and in HCC-bearing mice. In a subcutaneous HCC mouse model, we found that NHE-06 possessed both preventive and therapeutic functions. Moreover, rather than the cytotoxic effects, the antitumor efficacy of NHE-06 was indispensable of intact immunity, since the therapeutic effect was only achieved in immune-competent mice whereas failed in immune-compromised mice. Taken together, the novel formula of the anti-inflammatory NHE-06 effectively restores antitumor immune-surveillance and can be applied for prevention and/or treatment of inflammationrelated cancers.
Melanie M Garcia
Davao Doctors College, Philippines
Title: Ethno-botanical practices of Matigsalug tribe on medicinal plants at Barangay Baganihan, Marilog district, Davao city, Philippines
The field sampling and documentation was made at Barangay Baganihan, Marilog district Davao city, Philippines. It aims to determine the ethno-botanical practices and their ecological status of the medicinal plants used by Matigsalug tribe. Respondents were randomly selected aging 18 to 60 years old for the interview using validated survey questionnaires. Overall, there were 35 plants identified with 22 families. Family of Poaceae had the highest number of species. Matigsalug tribe mostly used leaves (28.57%), while the method of preparation was decoction (51.43%) and utilization of these medicinal plants was ingestion (57.1%). The study revealed 22 identified species with a fidelity value of 100%. The disease categories with the highest
informed consensus factor were dermatological diseases (0.9 ICF). Based on the field sampling, there was 36 species with 26 families identified. In terms of species diversity index, Shannon-Wiener Diversity Index was used and obtained its value H’=2.736177 which indicates a high species diversity in the area. The study revealed that the Matigsalug tribe was dependent on medicinal plants for their primary health care need. Therefore, there should be an educational program for awareness of the community on how to improve their practices and protection and conservation of the medicinal plants.
Cardiff Sixth Form College, UK
Title: Compare and review on the traditional medicine and modern medicine in the world
By looking at the history and developments of science, we find that many basic sciences such as mathematics, astronomy, philosophy, logic, geometry and physics maintain their logical and historical links with their written sources, and scientists in these fields study previous sources and mastering them in the production of science, innovation and technology in those fields. But in the field of medicine, there is a critical and important historical section that cuts medicine out of its 7,000 year history and puts it in a new and completely different direction, opposing its background. The importance of medicine in the life of all living beings, especially human beings, is a sign of salvation and healing. From the beginning of human life, according to the type of advancement, there have been different types of medicine and now, we have reached the current medicine over the time, sometimes due to shortcomings in modern science, with the return to the previous sciences, we attempt to eliminate the problems. Dependence on chemical drugs due to its harmful effects is a major concern among most people in society. For this reason, some people prefer acupuncture, pressure therapy and traditional or herbal remedies to treat their illnesses. Also, the traditional medicine has been accepted by many people through its success in being healthy. In this article, we try to look
at complementary and alternative medicine and compare the collected findings with current medicine.
Mohammad Zashim Uddin
University of Dhaka, Bangladesh
Title: Medicinal plants for the treatment of diabetes in Bangladesh
Mohammad Zashim Uddin is a Professor in the Department of Botany, University of Dhaka, Bangladesh. He has been published 66 research articles, books, book parts in different national and international scientific journals. He served as Biodiversity Expert in 22 research projects in Bangladesh. Apart from his research, he was involved with many scientific affiliated bodies. His current research focuses on traditional healthcare knowledge of herbal medicinal plants, taxonomy and conservation of threatened plants and conservation biology of tropical biodiversity.
The research article highlights the medicinal plants for the treatment of diabetes used by the local people of Bangladesh. The data were collected using semi-structure interviews with key informants during the year of 2014 and 2015. In some cases group discussion and informal conversation with local people were also conducted. A total of 41 medicinal plant species were recorded for the treatment of diabetes. These medicinal plant species assigned to 30 families. Among the medicinal plants, 56% are represented by trees, 25% by herbs, 11% by shrubs and 8% by climbers. The most frequently cited medicinal plants by the local people for the treatment of diabetes were Coccinia cordifolia, Momordica indica, Azadirachta indica, Syzygium cumini,
Terminalia arjuna, Aegle marmelos, Andrographis paniculata, Terminalia chebula, Averrhoa bilimbi and Swietenia mahagani. The data analysis was also confirmed the cultural bound medicinal plants of local people for diabetes treatment using fidelity value index. Among the medicinal plants Abelmoschus esculentus, Carissa carandas, Catharanthus roseus, Citrus aurantiifolia, Citrus grandis, Dillenia indica, Gynura nepalensis, Momordica indica, Swietenia mahagani, Syzygium cumini, Tinospora crispa and Ficus racemosa were attained 100% fidelity level values. Medicinal plants which were most cited by local people for diabetes treatment and medicinal plants with 100% Fl values may further subjected for phytochemical investigation to find pure bioactive compounds for the management of diabetes. As wild medicinal plants are in vulnerable in natural habitats, appropriate policy should be applied for sustainable local resource conservation, economic growth, primary healthcare and community development.