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Arman Zargaran

Arman Zargaran

Tehran University of Medical Sciences, Iran

Title: Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: A randomized, double-blind, placebo-controlled, crossover study

Biography

Biography: Arman Zargaran

Abstract

Phytotherapy is a source of finding new remedies for migraine. Traditional chamomile oil (chamomile extraction in sesame oil) is a formulation in Persian Medicine (PM) for pain relief in migraine. An oleogel preparation of reformulated traditional chamomile oil was prepared and then standardized based on chamazulene (as a marker in essential oil) and apigenin via Gas Chromatography (GC) and High-Performance Liquid Chromatography (HPLC) methods, respectively. A crossover doubleblind clinical trial was performed with 100 patients. Each patient took two tubes of drug and two tubes of placebo during the study. Visual Analog Scale (VAS) questionnaires were filled in by the patients and scores were given, ranging from 0 to 10 (based on the severity of pain) during 24 hours. Other complications like nausea, vomiting, photophobia and phonophobia were also monitored. There was 4.48±0.01 μl/ml of chamazulene and 0.233 mg/g of apigenin in the preparation (by correcting the amount with extraction ratio). 38 patients in the drug-placebo and 34 patients in the placebo-drug groups (a total number of 72 patients as per protocol) completed the process in the Randomized Controlled Trial (RCT). Adapted results from the questionnaires showed that pain, nausea, vomiting, photophobia and phonophobia significantly (p<0.001) decreased by using chamomile oleo-gel on the patients after 30 minutes. Results supported the efficacy of chamomile oleogel as a pain relief in migraine without aura.