Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer


4th Global Summit on Herbals and Traditional Medicine

Osaka, Japan

Nutda Sutthammikorn

Nutda Sutthammikorn

Chiang Mai University, Thailand

Title: Evaluation of wound healing efficacy of Gynura procumbens leaf extract in streptozotocin-induced diabetic mice
Notice: Undefined index: tittle in /var/www/universal_code/abstract-details.php on line 211


Biography: Nutda Sutthammikorn


Wound healing impairment in the diabetic foot ulcers is the most frequently recognized complication in diabetic patients. Therefore, there is a substantially unmet need to develop new interventions that are effective, cheap and with fewer side effect burdens. Gynura procumbens (GP) is commonly found in Southeast Asian countries. The leaves extract of GP are used in folk medicine for treatment of various ailments such as fever, rash, inflammation, kidney disease, migraine, rheumatism, cancer, viral infection, hypertension, hyperglycemic and hyperlipidemia. However, the effect of GP on the healing of diabetic wounds has not been reported. In this study we examined the effects of GP gel treatment on wound healing in streptozotocin-induced diabetic mice and found that GP treatment significantly promoted wound healing faster than solcoseryl jelly, which is usually used as a wound healing drug in diabetic patients. GP also promoted angiogenesis around the wound area, and significantly increased the skin expression of angiogenin, endothelial growth factor, fibroblast growth factor, transforming growth factor ß1 and vascular endothelial growth factor in both normal and diabetic mice. Moreover, GP elevated the expression of various growth factors in human fibroblasts, keratinocytes, endothelial cells and mast cells. Interestingly, GP promoted keratinocyte and fibroblast proliferation and enhanced fibroblast, keratinocyte and mast cell migration. These findings suggest that GP may be used as a wound healing drug in diabetic ulcers.

Notice: Undefined index: key_pdf in /var/www/universal_code/abstract-details.php on line 279

Notice: Undefined index: key_pdf in /var/www/universal_code/abstract-details.php on line 320