Kaur Gurcharan
Guru Nanak Dev University, India
Biography
Prof. Gurcharan Kaur has scientifically validated the Indian traditional practices of Natural products from medicinal plants. Her laboratory presented the first ever pre-clinical evidence for Withania somnifera and Tinospora cordifolia extracts as potential agents with capability for neuronal differentiation, an attractive supplementary therapeutic approach for the treatment of brain cancers. An in vivo study from her lab explored the anxiolytic and immunomodulatory potential of ASH-WEX in acute sleep deprived female Wistar rats. ASH-WEX treated animals showed reduced anxiety in Elevated Plus Maze test along with reduction in expression of pro-inflammatory cytokines TNFα, IL-1β and IL-6. ASH-WEX was also instrumental in enhancing cell survival and reducing apoptosis as witnessed from downregulation of NFκB, AP-1, cytochrome c and upregulation of Bcl-xL. Her detailed mechanistic studies of potential interventions by natural products promise to offer a unique therapeutic strategy in amelioration of neuroinflammation and neurological disorders associated with obesity and sleep disorders.
Abstract
Abstract : Neuroplasticity and anti-neuroinflammatory activity in water extract from leaf of Withania somnifera