Susy Tjahjani
Maranatha Christian University, Indonesia
Title: Major xanthone of Garciniamangostana L rind and curcumin and interaction with an artemisinin derivate for malaria in vitro
Biography
Biography: Susy Tjahjani
Abstract
In order to overcome malarial resistance tendency against ACT (artemisinin based combination therapy), several galenic preparations of Garcinia mangostana L rind have been studied and they have antimalarial activity in vitro. One of the major xanthones in this rind may contribute to this activity. Curcumin as one of the major compound of Curcuma domestica, is also potentially to have antimalarial activity. The aim of this study was to evaluate the antimalarial activity of this xanthone, curcumin, and one derivate of artemisinins and also to evaluate their mechanism of action. Interaction between them each other as antimalarial in vitro was also studied. Antimalarial activity was studied in in vitro 3D7 Plasmodium falciparum cultivation incubated with these compounds to look for the IC50 and ∑FIC50 of them. The mechanism of action of these compounds was observed electron microscopically. The result of this promising study would be reported.